Mitochondrial regulation of apoptotic cell death

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

2005 • 2,148 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004 • 1,977 citations

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

2005 • 1,570 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x_L, but not Bcl-2, until displaced by BH3-only proteins

2005 • 1,210 citations

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

2005 • 1,169 citations

Microdomains with High Ca ²⁺ Close to IP ₃ -Sensitive Channels that Are Sensed by Neighboring Mitochondria

1993 • 1,167 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

2005 • 1,102 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002 • 1,015 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Cytochrome c release from mitochondria proceeds by a two-step process

2002 • 917 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

The biosynthesis and functional role of cardiolipin

2000 • 786 citations

Superoxide in Apoptosis

1998 • 773 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Mitochondrial control of apoptosis: the role of cytochrome c

1998 • 751 citations

The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

2004 • 654 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

2000 • 619 citations

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

1998 • 588 citations

Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain

2004 • 587 citations

Acetylation of the C Terminus of Ku70 by CBP and PCAF Controls Bax-Mediated Apoptosis

2004 • 569 citations

Apoptosis driven by IP3-linked mitochondrial calcium signals

1999 • 492 citations

Mitochondrial regulation of apoptotic cell death

2004 • 474 citations

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

2003 • 468 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 442 citations

Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced Apoptosis

2002 • 421 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Mitochondria and Ischemia/Reperfusion Injury

2005 • 376 citations

Essential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian Cells

2001 • 360 citations

Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

2000 • 349 citations

Molecular Mechanisms of Apoptosis Induced by Cytotoxic Chemicals

2000 • 345 citations

Cardiolipin Is Essential for Organization of Complexes III and IV into a Supercomplex in Intact Yeast Mitochondria

2005 • 321 citations

DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

2003 • 307 citations

Phospholipid-Cytochrome c Interaction

2002 • 306 citations

Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

2005 • 304 citations

Caspases Induce Cytochrome c Release from Mitochondria by Activating Cytosolic Factors

1999 • 302 citations

Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition

1998 • 294 citations

Decreased Cardiolipin Synthesis Corresponds with Cytochromec Release in Palmitate-induced Cardiomyocyte Apoptosis

2001 • 290 citations

Release of cytochrome c and decrease of cytochrome c oxidase in Bax‐expressing yeast cells, and prevention of these effects by coexpression of Bcl‐x_L

1997 • 288 citations

Review: Nuclear Events in Apoptosis

2000 • 283 citations

Dithiocarbamates Induce Apoptosis in Thymocytes by Raising the Intracellular Level of Redox-active Copper

1995 • 280 citations

Reversibility of the Binding of Cytochrome c to Liposomes

1995 • 258 citations

Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation

1999 • 248 citations

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

2000 • 244 citations

Cytochrome c binding to enzymes and membranes

1974 • 242 citations

Modulation of the mitochondrial megachannel by divalent cations and protons.

1992 • 232 citations

Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax

2002 • 225 citations

The inner mitochondrial membrane contains ion‐conducting channels similar to those found in bacteria

1989 • 224 citations

Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases

1995 • 224 citations

Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef‐heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis

2001 • 217 citations

Induction of the Mitochondrial Permeability Transition Causes Release of the Apoptogenic Factor Cytochrome c

1998 • 216 citations

Anionic phospholipids are determinants of membrane protein topology

1997 • 210 citations

Cytochrome c Release Occurs via Ca2+-dependent and Ca2+-independent Mechanisms That Are Regulated by Bax

2001 • 206 citations

Mitochondrial channel activity studied by patch-clamping mitoplasts

1989 • 206 citations

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein

2002 • 192 citations

Bid, but Not Bax, Regulates VDAC Channels

2004 • 192 citations

Reversible, nonionic, and pH-dependent association of cytochrome c with cardiolipin-phosphatidylcholine liposomes.

1992 • 177 citations

The reversible Ca2+-induced permeabilization of rat liver mitochondria

1986 • 174 citations

Loss of cardiolipin and mitochondria during programmed neuronal death: evidence of a role for lipid peroxidation and autophagy

2002 • 170 citations

Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis

2004 • 155 citations

Mechanism of Dithiocarbamate Inhibition of Apoptosis: Thiol Oxidation by Dithiocarbamate Disulfides Directly Inhibits Processing of the Caspase-3 Proenzyme

1997 • 135 citations

Oxidative phosphorylation in cardiolipin-lacking yeast mitochondria

2000 • 126 citations

Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity

2004 • 125 citations

Inhibition of mitochondrial calcium-independent phospholipase A2 (iPLA2) attenuates mitochondrial phospholipid loss and is cardioprotective

2002 • 124 citations

Caspase-2 Permeabilizes the Outer Mitochondrial Membrane and Disrupts the Binding of Cytochrome c to Anionic Phospholipids

2004 • 115 citations

Bcl-2 Family Members as Sentinels of Cellular Integrity and Role of Mitochondrial Intermembrane Space Proteins in Apoptotic Cell Death

2003 • 110 citations

Multiple Conformations of Physiological Membrane-Bound Cytochrome c

1998 • 91 citations

Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis

2002 • 88 citations

Mitochondrial iPLA2 Activity Modulates the Release of Cytochrome c from Mitochondria and Influences the Permeability Transition

2006 • 88 citations

Arsenic stimulates release of cytochrome from isolated mitochondria via induction of mitochondrial permeability transition

2005 • 82 citations

Inhibition of Bax-Induced CytochromecRelease from Neural Cell and Brain Mitochondria by Dibucaine and Propranolol

2003 • 78 citations

Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria

2004 • 74 citations

Essential Roles of the Bcl-2 Family of Proteins in Caspase-2-induced Apoptosis

2005 • 71 citations

Purification of VDAC (Voltage-dependent anion-selective channel) from rat liver mitochondria

1983 • 70 citations

Asymmetrical distribution of cardiolipin in yeast inner mitochondrial membrane triggered by carbon catabolite repression

1997 • 68 citations

Bax and Bak are required for cytochrome c release during arsenic trioxide-induced apoptosis

2005 • 66 citations

Tributyltin-Induced Apoptosis Requires Glycolytic Adenosine Trisphosphate Production

1999 • 66 citations

Evaluation of the role of peroxisome-proliferator-activated receptor α in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism

2002 • 64 citations

Role of Fas–Fas Ligand Interactions in 2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD)-Induced Immunotoxicity: Increased Resistance of Thymocytes from Fas-Deficient (lpr) and Fas Ligand-Defective (gld) Mice to TCDD-Induced Toxicity

1999 • 63 citations

Initiation of Apoptotic Signal by the Peroxidation of Cardiolipin of Mitochondria

2004 • 60 citations

Activation of calcium‐independent phospholipase A₂ (iPLA₂) in brain mitochondria and release of apoptogenic factors by BAX and truncated BID

2005 • 54 citations

Overexpression of Bcl‐2 suppresses the calcium activation of a mitochondrial megachannel

2001 • 53 citations

Pore Formation and Uncoupling Initiate a Ca²⁺-Independent Degradation of Mitochondrial Phospholipids

2002 • 51 citations

Structure of cytochrome c complexes with phospholipids as revealed by resonance energy transfer

1999 • 39 citations

Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart

2000 • 36 citations

Binding and Release of Cytochrome c in Brain Mitochondria Is Influenced by Membrane Potential and Hydrophobic Interactions with Cardiolipin

2004 • 33 citations

Isolation and characterization of highly purified mitochondrial outer membranes of the yeast Saccharomyces cerevisiae (Method)

1999 • 32 citations

Dual localization of the mitochondrial phospholipase A2: outer membrane contact sites and inner membrane

1992 • 22 citations

The Ca2+ threshold for the mitochondrial permeability transition and the content of proteins related to Bcl-2 in rat liver and Zajdela hepatoma mitochondria.

1999 • 20 citations