Caspase-2 Permeabilizes the Outer Mitochondrial Membrane and Disrupts the Binding of Cytochrome c to Anionic Phospholipids

Cell Death

2004 • 4,599 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

2004 • 654 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria

2002 • 511 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced Apoptosis

2002 • 421 citations

Alice in caspase land. A phylogenetic analysis of caspases from worm to man

2002 • 376 citations

Caspase Activation

2004 • 332 citations

Phospholipid-Cytochrome c Interaction

2002 • 306 citations

Apoptosis and genomic instability

2004 • 284 citations

Lipidic Pore Formation by the Concerted Action of Proapoptotic BAX and tBID

2004 • 234 citations

The cardiolipin–cytochrome c interaction and the mitochondrial regulation of apoptosis

2004 • 228 citations

The biochemical mechanism of caspase-2 activation

2004 • 201 citations

A novel Apaf-1–independent putative caspase-2 activation complex

2002 • 165 citations

Bid-Cardiolipin Interaction at Mitochondrial Contact Site Contributes to Mitochondrial Cristae Reorganization and CytochromecRelease

2004 • 157 citations

Distinct Pathways for Stimulation of Cytochrome cRelease by Etoposide

2000 • 155 citations

Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity

2004 • 125 citations

Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria

2004 • 74 citations

Ultracentrifugation Technique for Measuring the Binding of Peptides and Proteins to Sucrose-Loaded Phospholipid Vesicles

2003 • 66 citations

Membrane perturbations induced by the apoptotic Bax protein

2002 • 43 citations