The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

The Inflammasome

2002 • 5,445 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

Many cuts to ruin: a comprehensive update of caspase substrates

2003 • 1,021 citations

A Unified Model for Apical Caspase Activation

2003 • 946 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria

2002 • 511 citations

The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex

2002 • 475 citations

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

2003 • 467 citations

Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced Apoptosis

2002 • 421 citations

Alice in caspase land. A phylogenetic analysis of caspases from worm to man

2002 • 376 citations

Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

2000 • 349 citations

Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid

2000 • 346 citations

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

1997 • 252 citations

Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity

2003 • 179 citations

A novel Apaf-1–independent putative caspase-2 activation complex

2002 • 165 citations

LRDD, a novel leucine rich repeat and death domain containing protein

2000 • 51 citations