Mechanism of Dithiocarbamate Inhibition of Apoptosis: Thiol Oxidation by Dithiocarbamate Disulfides Directly Inhibits Processing of the Caspase-3 Proenzyme

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Environmental Health Criteria 75

1989 • 1,024 citations

The Dithiocarbamates and Related Compounds

1963 • 500 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Control of apoptosis by the cellular ATP level

1996 • 465 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32

1996 • 295 citations

Thiol-mediated redox regulation of apoptosis. Possible roles of cellular thiols other than glutathione in T cell apoptosis.

1995 • 239 citations

Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems

1986 • 235 citations

Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL

1996 • 190 citations

A role for metals and free radicals in the induction of apoptosis in thymocytes

1994 • 175 citations

Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.

1996 • 167 citations

Dithiocarbamates and the redox regulation of cell death

1996 • 121 citations

S-Methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase

1995 • 31 citations

In vitro Inactivation of Yeast Glutathione Reductase by Tetramethylthiuram Disulphide

1995 • 11 citations