Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Differentiated Rat Glial Cell Strain in Tissue Culture

1968 • 1,480 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

A model system for in vivo gene transfer into the central nervous system using an adenoviral vector

1993 • 588 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

1978 • 560 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. National Institutes of Health

1993 • 420 citations

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

1993 • 387 citations

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

1993 • 380 citations

Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector

1990 • 325 citations

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy.

1991 • 315 citations

Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1–deleted adenoviruses

1993 • 303 citations

Adenovirus as an expression vector in muscle cells in vivo.

1992 • 301 citations

Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.

1991 • 216 citations

Lymphoma Regression Induced by Ganciclovir in Mice Bearing a Herpes Thymidine Kinase Transgene

1990 • 208 citations

In vivo growth of C6 glioma cells transfected with connexin43 cDNA.

1992 • 172 citations

Gene therapy of maliganant brain tumors: A rat glioma line bearing the herpes simplex virus type 1‐thymidine kinase gene and wild type retrovirus kills other tumor cells

1992 • 170 citations

Expression of gap junction genes in astrocytes and C6 glioma cells

1991 • 118 citations

Selective elimination of recombinant genes in vivo with a suicide retroviral vector.

1991 • 63 citations