Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study

A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

1988 • 1,288 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors.

1988 • 379 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.

1994 • 316 citations

Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy.

1994 • 247 citations

Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?

1994 • 245 citations

Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma.

1993 • 221 citations

Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes.

1991 • 187 citations

Direct evidence to support the immunosurveillance concept in a human regressive melanoma.

1994 • 171 citations

Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood.

1990 • 160 citations

Precursor frequency analysis of human cytolytic T lymphocytes directed against autologous melanoma cells

1992 • 132 citations

Complete responses and long-term survivals after systemic chemotherapy for patients with advanced malignant melanoma

1989 • 105 citations

Therapy for cutaneous melanoma: An update

1990 • 97 citations

Membrane transport proteins associated with drug resistance expressed in human melanoma.

1995 • 80 citations

Regulation of human cytotoxic T lymphocyte development by IL-7.

1990 • 78 citations

Effects of IL-7 and IL-2 on highly enriched CD56+ natural killer cells. A comparative study.

1991 • 70 citations

Chemosensitivity testing of human malignant melanoma. A retrospective analysis of clinical response and in vitro drug sensitivity

1994 • 64 citations

Autoreactive T cells in healthy individuals show tolerance in vitro with characteristics similar to but distinct from clonal anergy

1995 • 57 citations

A Pilot Study of Immunization with HLA-A2 Matched Allogeneic Melanoma Cells That Secrete Interleukin-2 in Patients with Metastatic Melanoma

1992 • 57 citations

Effects of Human Immunodeficiency Virus on the Cellular Immune Response to Epstein-Barr Virus in Homosexual Men: Characterization of the Cytotoxic Response and Lymphokine Production

1987 • 48 citations

Considerations for the Use of Cytokine-Secreting Tumor Cell Preparations for Cancer Treatment

1995 • 46 citations

Transduction of human melanoma cell lines with the human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2

1993 • 46 citations

Metastatic potential of human melanoma cells in nude mice - characterisation of phenotype, cytokine secretion and tumour-associated antigens

1996 • 45 citations

Frequency analysis of tumor-reactive cytotoxic T lymphocytes in peripheral blood of a melanoma patient vaccinated with autologous tumor cells

1994 • 38 citations

Cytokines and clinical gene therapy

1995 • 37 citations

Induction of primary anti‐viral cytotoxic T cells by in vitro stimulation with short synthetic peptide and interleukin‐7

1992 • 32 citations

Interleukin-7, interleukin-12, and GM-CSF gene transfer in patients with metastatic melanoma

1995 • 25 citations

Lysis of allogeneic and autologous melanoma cells by IL-7-induced lymphokine-activated killer cells

1994 • 22 citations

Measuring success in clinical gene therapy research

1996 • 11 citations