Genetic modification of a carcinoma with the IL-4 gene increases the influx of dendritic cells relative to other cytokines

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.

1975 • 573 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells.

1987 • 523 citations

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 • 478 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines.

1995 • 318 citations

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.

1991 • 315 citations

Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines

1996 • 308 citations

Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

1995 • 277 citations

Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines

1996 • 256 citations

Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors.

1996 • 248 citations

Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?

1994 • 245 citations

Efficient Interaction of HIV-1 with Purified Dendritic Cells via Multiple Chemokine Coreceptors

1996 • 245 citations

TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma

1983 • 223 citations

Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers.

1993 • 198 citations

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.

1992 • 185 citations

Amount of interleukin 12 available at the tumor site is critical for tumor regression.

1996 • 177 citations

Regression of an established tumor genetically modified to release granulocyte colony-stimulating factor requires granulocyte-T cell cooperation and T cell-produced interferon gamma.

1993 • 171 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

Human renal-cell carcinoma tissue contains dendritic cells

1996 • 152 citations

MIGRATION PATTERNS OF DENDRITIC LEUKOCYTES

1990 • 139 citations

Tumor immunotherapy: the tumor cell as an antigen-presenting cell

1994 • 132 citations

An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.

1994 • 130 citations

Tissue Distribution of the DEC-205 Protein That Is Detected by the Monoclonal Antibody NLDC-145

1995 • 129 citations

B7-1 and interleukin 12 synergistically induce effective antitumor immunity.

1995 • 118 citations

Immortalized dendritic cell line fully competent in antigen presentation initiates primary T cell responses in vivo.

1993 • 108 citations

IgG immune response toHelicobacter pylori antigens in patients with gastric cancer as defined by ELISA and immunoblotting

1996 • 105 citations

Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells.

1996 • 77 citations

Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells.

1996 • 67 citations

Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines.

1996 • 63 citations

A tumor escape variant that has lost one major histocompatibility complex class I restriction element induces specific CD8+ T cells to an antigen that no longer serves as a target.

1993 • 62 citations

Anticancer role of dendritic cells (DC) in human and experimental cancers--a review.

1992 • 60 citations

Internalization of Ia Molecules into Birbeck Granule-Like Structures in Murine Dendritic Cells

1992 • 38 citations

Analysis of the Effect of Cytokines (Interleukins 2, 3, 4, and 6, Granulocyte-Monocyte Colony-Stimulating Factor, and Interferon-γ) on Generation of Primary Cytotoxic T Lymphocytes against a Weakly Immunogenic Tumor

1995 • 28 citations