Cancer vaccines: the interleukin 2 dosage effect.

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

1992 • 483 citations

5′–3′ Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis

1988 • 336 citations

Experimental and Clinical Studies of Cytokine Gene-Modified Tumor Cells

1994 • 259 citations

New Approaches to the Immunotherapy of Cancer Using Interleukin-2

1988 • 202 citations

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.

1992 • 185 citations

Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus.

1994 • 167 citations

[42] Receptor-mediated transport of DNA into eukaryotic cells

1993 • 115 citations

The role of IL-2 secreted from genetically modified tumor cells in the establishment of antitumor immunity.

1994 • 85 citations

Interleukin 2‐dependent activation of tumor‐specific cytotoxic T lymphocytes in vivo

1991 • 81 citations

Combination effect of vaccination with IL2 and IL4 cdna transfected cells on the induction of a therapeutic immune response against lewis lung carcinoma cells

1993 • 42 citations

Somatic gene therapy for cancer: the utility of transferrinfection in generating ‘tumor vaccines’

1993 • 35 citations