Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

1986 • 1,154 citations

A Fluorometric Assay for the Measurement of Nitrite in Biological Samples

1993 • 1,022 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

1993 • 734 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Induction of Nitric Oxide Synthase in Glial Cells

1992 • 501 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1992 • 484 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.

1992 • 428 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

Nitric oxide: biosynthesis and biological significance

1989 • 421 citations

Tumor Necrosis Factor and Granulocyte Macrophage-Colony Stimulating Factor Stimulate Human Macrophages to Restrict Growth of Virulent Mycobacterium avium and to Kill Avirulent M. avium: Killing Effector Mechanism Depends on the Generation of Reactive Nitrogen Intermediates

1991 • 390 citations

Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions

1986 • 383 citations

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

1993 • 355 citations

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

1993 • 353 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

THE HISTOLOGY OF DISSEMINATED SCLEROSIS.

1916 • 245 citations

Nitric oxide, a biological effector

1991 • 203 citations

Multiple sclerosis: Involvement of interferons in lesion pathogenesis

1988 • 188 citations

Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study.

1993 • 153 citations

Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute experimental autoimmune encephalomyelitis: enhancement by the soluble products of encephalitogenic T cells.

1992 • 136 citations

Electron microscopy and immunoperoxidase studies of early multiple sclerosis lesions

1976 • 113 citations

Aminoguanidine inhibits oxidative modification of low density lipoprotein protein and the subsequent increase in uptake by macrophage scavenger receptors.

1992 • 110 citations

Fluorometric determination of nitrite

1986 • 93 citations

Adoptively transferred chronic relapsing experimental autoimmune encephalomyelitis in the mouse. Neuropathologic analysis.

1984 • 86 citations

Immunopathology of the lesion in chronic relapsing experimental autoimmune encephalomyelitis in the mouse

1986 • 79 citations

Experimental autoimmune encephalomyelitis. Augmentation of demyelination by different myelin lipids.

1984 • 67 citations

The T Lymphocyte In Experimental Allergic Encephalomyelitis

1990 • 41 citations

Adoptively transferred acute and chronic relapsing autoimmune encephalomyelitis in the PL/J mouse and observations on altered pathology by intercurrent virus infection.

1987 • 35 citations

THE EFFECT OF ENZYME INHIBITORS ON HISTAMINE CATABOLISM IN MAN

1960 • 30 citations

Neuropathology of Multiple Sclerosis

1975 • 24 citations

Monoaminoguanidine inhibits aldose reductase

1991 • 23 citations

Serial adoptive transfer of murine experimental allergic encephalomyelitis: successful transfer is dependent on active disease in the donor

1990 • 11 citations

Experimental allergic encephalomyelitis, a useful model for multiple sclerosis. A satellite conference of the International Society of Neurochemists. Seattle, Washington, July 16-19, 1983.

1984 • 3 citations

Deleted Work

1955 • 0 citations