Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.

1993 • 785 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1992 • 534 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.

1993 • 411 citations

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

1993 • 391 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

1992 • 344 citations

Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells

1988 • 342 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase.

1976 • 261 citations

Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate

1993 • 260 citations

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

1990 • 240 citations

Kinetic characteristics of nitric oxide synthase from rat brain

1990 • 210 citations

Ca2+/calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase.

1992 • 210 citations

Control of heme protein redox potential and reduction rate: linear free energy relation between potential and ferric spin state equilibrium

1985 • 181 citations

NG-Methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase

1993 • 178 citations

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

1992 • 174 citations

Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues

1991 • 166 citations

Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation.

1994 • 155 citations

Calcium/calmodulin-dependent nitric oxide synthase type I: a biopteroflavoprotein with calcium/calmodulin-independent diaphorase and reductase activities

1992 • 151 citations

Characterization of the Flavoprotein Moieties of NADPH-Sulfite Reductase from Salmonella typhimurium and Escherichia coli

1989 • 149 citations

Sulfur donor ligand binding to ferric cytochrome P-450-CAM and myoglobin. Ultraviolet-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopic investigation of the complexes.

1982 • 140 citations

Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages.

1993 • 134 citations

An unusual yet strongly conserved flavoprotein reductase in bacteria and mammals

1991 • 126 citations

Synthesis of L-Thiocitrulline, L-Homothiocitrulline, and S-Methyl-L-thiocitrulline: A New Class of Potent Nitric Oxide Synthase Inhibitors

1994 • 107 citations

L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.

1994 • 100 citations

Heme coordination and structure of the catalytic site in nitric oxide synthase.

1993 • 99 citations

The diverse spectroscopic properties of ferrous cytochrome P-450-CAM ligand complexes.

1983 • 97 citations

Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imidazole and phenylimidazoles

1993 • 88 citations

Kinetics of reduction of cytochrome P-450LM4 in a reconstituted liver microsomal enzyme system.

1979 • 77 citations

Formation of Complexes between Microsomal Cytochrome P‐450‐Fe(II) and Nitrosoarenes Obtained by Oxidation of Arylhydroxylamines or Reduction of Nitroarenes in situ

1978 • 56 citations

Synthesis of the putative l-arginine metabolite L-NG-hydroxyarginine

1991 • 38 citations

The kinetics of reduction of cytochrome P-450cam by the dithionite anion monomer.

1980 • 26 citations

P450BM-3: Reduction by NADPH and sodium dithionite

1992 • 23 citations