The Human Insulin Gene Displays Transcriptionally Active Epigenetic Marks in Islet-Derived Mesenchymal Precursor Cells in the Absence of Insulin Expression

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

2006 • 5,132 citations

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

2004 • 2,188 citations

International Trial of the Edmonton Protocol for Islet Transplantation

2006 • 1,869 citations

Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse

2005 • 1,497 citations

Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast

2005 • 1,418 citations

Histone modifications in transcriptional regulation

2002 • 1,200 citations

Cellular Memory and the Histone Code

2002 • 1,137 citations

Controlling the double helix

2003 • 1,102 citations

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

2004 • 1,049 citations

Rb targets histone H3 methylation and HP1 to promoters

2001 • 892 citations

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

2004 • 788 citations

Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin

2005 • 690 citations

Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus

2001 • 582 citations

Enhanced Histone Acetylation and Transcription: A Dynamic Perspective

2006 • 460 citations

Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells

2004 • 430 citations

Histone H3 variants and their potential role in indexing mammalian genomes: The “H3 barcode hypothesis”

2006 • 415 citations

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.

2002 • 383 citations

In Vivo and In Vitro Characterization of Insulin-Producing Cells Obtained From Murine Bone Marrow

2004 • 382 citations

Regulation of insulin gene transcription

2002 • 354 citations

Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer

2002 • 352 citations

Histone modifications: signalling receptors and potential elements of a heritable epigenetic code

2006 • 314 citations

Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells

2004 • 295 citations

Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9

2003 • 293 citations

Human Bone Marrow Mesenchymal Stem Cells Can Express Insulin and Key Transcription Factors of the Endocrine Pancreas Developmental Pathway upon Genetic and/or Microenvironmental Manipulation In Vitro

2005 • 256 citations

Histone H3 Lys 4 methylation: caught in a bind?

2006 • 232 citations

Concise Review: Epigenetic Mechanisms Contribute to Pluripotency and Cell Lineage Determination of Embryonic Stem Cells

2006 • 190 citations

In vitro trans-differentiation of rat mesenchymal cells into insulin-producing cells by rat pancreatic extract

2005 • 183 citations

The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation

2002 • 181 citations

Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene Transcription in Pancreatic β Cells

2003 • 141 citations

Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus

2003 • 138 citations

Pancreatic Islet Transplantation

2004 • 121 citations

Regulation of insulin gene transcription

2000 • 117 citations

Human Islet-Derived Precursor Cells Are Mesenchymal Stromal Cells That Differentiate and Mature to Hormone-Expressing Cells In Vivo

2007 • 115 citations

Glucose Regulates Insulin Gene Transcription by Hyperacetylation of Histone H4

2003 • 100 citations

Recent developments and future prospects in pancreatic and islet transplantation

2001 • 94 citations

The epigenetic basis for embryonic stem cell pluripotency

2005 • 63 citations

Chromatin, epigenetics and stem cells

2005 • 55 citations

Are Better Islet Cell Precursors Generated by Epithelial-to-Mesenchymal Transition?

2005 • 36 citations

How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation

2006 • 8 citations