Investigating stem cells in human colon by using methylation patterns

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

CpG island methylator phenotype in colorectal cancer

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High sensitivity mapping of methylated cytosines

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DNA Modification Mechanisms and Gene Activity During Development

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Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

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Mutator phenotype may be required for multistage carcinogenesis.

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Mutation selection and the natural history of cancer

2006 • 1,185 citations

A Niche Maintaining Germ Line Stem Cells in the Drosophila Ovary

2000 • 760 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Aging and DNA methylation in colorectal mucosa and cancer.

1998 • 620 citations

DNA methylation: past, present and future directions

2000 • 609 citations

CpG islands and genes

1995 • 449 citations

Methylation Patterns of the E-cadherin 5′ CpG Island Are Unstable and Reflect the Dynamic, Heterogeneous Loss of E-cadherin Expression during Metastatic Progression

2000 • 387 citations

Somatic support cells restrict germline stem cell self-renewal and promote differentiation

2000 • 381 citations

A Modified and Improved Method for Bisulphite Based Cytosine Methylation Analysis

1996 • 378 citations

Gut instincts: thoughts on intestinal epithelial stem cells

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Stem cells: the intestinal stem cell as a paradigm

2000 • 314 citations

The latent roots of certain Markov chains arising in genetics: A new approach, I. Haploid models

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Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

1990 • 264 citations

Somatic control over the germline stem cell lineage during Drosophila spermatogenesis

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Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine

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Measurement of in vivo proliferation in human colorectal mucosa using bromodeoxyuridine.

1992 • 218 citations

Somatic Mutations Are Frequent and Increase with Age in Human Kidney Epithelial Cells

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Genetic reconstruction of individual colorectal tumor histories

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Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization

1991 • 136 citations

A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa.

1992 • 101 citations

Variability of DNA methylation patterns during serial passage of human diploid fibroblasts

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N-ethyl-N-nitrosourea treatment of multiple intestinal neoplasia (Min) mice: age-related effects on the formation of intestinal adenomas, cystic crypts, and epidermoid cysts.

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Post-irradiation somatic mutation and clonal stabilisation time in the human colon.

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Mosaic Methylation in Clonal Tissue

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Application of the crypt-isolation technique to flow-cytometric analysis of DNA content in colorectal neoplasms

1994 • 48 citations

Instability of X chromosome methylation in aberrant crypt foci of the human colon.

2000 • 34 citations

Analysis of human peripheral blood T cells and single-cell-derived T cell clones uncovers extensive clonal CpG island methylation heterogeneity throughout the genome

1999 • 28 citations