The New Field Of Epigenomics: Implications for Cancer and Other Common Disease Research

The language of covalent histone modifications

2000 • 8,260 citations

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

1999 • 4,776 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Epigenetic Reprogramming in Mammalian Development

2001 • 2,978 citations

The polycomb group protein EZH2 is involved in progression of prostate cancer

2002 • 2,600 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Health: United States

1986 • 2,293 citations

The history of cancer epigenetics

2004 • 2,270 citations

The DNA methyltransferases of mammals

2000 • 1,981 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Induction of Tumors in Mice by Genomic Hypomethylation

2003 • 1,479 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

2002 • 1,231 citations

Genomic imprinting in mammalian development: a parental tug-of-war

1991 • 1,178 citations

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

1999 • 1,168 citations

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells

1982 • 1,002 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Growing Y-junction carbon nanotubes

1999 • 815 citations

Relaxation of imprinted genes in human cancer

1993 • 792 citations

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

2003 • 740 citations

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

1995 • 601 citations

Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila

1994 • 506 citations

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

1994 • 466 citations

CpG methylation is maintained in human cancer cells lacking DNMT1

2000 • 453 citations

An integrated epigenetic and genetic approach to common human disease

2004 • 442 citations

Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia

2003 • 428 citations

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

2003 • 420 citations

Uniparental disomy in humans: development of an imprinting map and its implications for prenatal diagnosis

1995 • 410 citations

MATING-TYPE GENE SWITCHING IN SACCHAROMYCES CEREVISIAE

1998 • 405 citations

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution

2002 • 398 citations

Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.

2002 • 385 citations

Human disease genes

2001 • 383 citations

Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy

2003 • 379 citations

Cloned mice have an obese phenotype not transmitted to their offspring

2002 • 363 citations

Polycomb, Epigenomes, and Control of Cell Identity

2003 • 343 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

Neighboring-Nucleotide Effects on the Rates of Germ-Line Single-Base-Pair Substitution in Human Genes

1998 • 319 citations

Epigenetic lesions at the H19 locus in Wilms' tumour patients

1994 • 318 citations

CTCF maintains differential methylation at the Igf2/H19 locus

2002 • 313 citations

Genome-wide scan for body composition in pigs reveals important role of imprinting

2000 • 300 citations

Transgenic RNAi Reveals Essential Function for CTCF in H19 Gene Imprinting

2004 • 291 citations

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

1998 • 290 citations

Epigenetic Alterations of H19 and LIT1 Distinguish Patients with Beckwith-Wiedemann Syndrome with Cancer and Birth Defects

2002 • 274 citations

Early death of mice cloned from somatic cells

2002 • 274 citations

Role of DNA 5-Methylcytosine Transferase in Cell Transformation by fos

1999 • 237 citations

DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms

2002 • 226 citations

Age-Associated Activation of Epigenetically Repressed Genes in the Mouse

2003 • 196 citations

A Genome-Wide Screen for Normally Methylated Human CpG Islands That Can Identify Novel Imprinted Genes

2002 • 182 citations

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach

2004 • 180 citations

Autosomal and X-chromosome imprinting

1990 • 176 citations

Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome

2001 • 162 citations

Epigenetic changes at the insulin-like growth factor II/ H19 locus in developing kidney is an early event in Wilms tumorigenesis

1997 • 116 citations

Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging.

1993 • 100 citations

Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions

2003 • 99 citations

Human diseases with underlying defects in chromatin structure and modification

2001 • 97 citations

Loss of Insulin-Like Growth Factor-II Imprinting and the Presence of Screen-Detected Colorectal Adenomas in Women

2004 • 80 citations

Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus

2002 • 78 citations

Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1

2004 • 73 citations

Chromatin remodeling and human disease

2003 • 72 citations

DNA methylation and cell memory

1989 • 50 citations

Mechanisms for the construction and developmental control of heterochromatin formation and imprinted chromosome domains

1990 • 46 citations

Epigenetic variability and the evolution of human cancer

2003 • 37 citations

Transcription and chromatin converge: lessons from yeast genetics

2001 • 20 citations