Tubular complexes as a source for islet neogenesis in the pancreas of diabetes-prone BB rats

Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

2002 • 1,500 citations

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

2001 • 788 citations

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

2000 • 681 citations

A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development

1993 • 650 citations

NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

2003 • 446 citations

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

2000 • 443 citations

Gene expression cascades in pancreatic development

2002 • 350 citations

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.

1999 • 339 citations

Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes

2001 • 298 citations

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3

2002 • 269 citations

Gastrin Stimulates β-Cell Neogenesis and Increases Islet Mass From Transdifferentiated but Not From Normal Exocrine Pancreas Tissue

2002 • 253 citations

Perspective: Postnatal Pancreatic β Cell Growth

2000 • 248 citations

Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis

2002 • 229 citations

Prospective Isolation of Multipotent Pancreatic Progenitors Using Flow-Cytometric Cell Sorting

2004 • 223 citations

Nestin expression in pancreatic stellate cells and angiogenic endothelial cells

2002 • 215 citations

Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro

2000 • 198 citations

Malignant transformation of duct-like cells originating from acini in transforming growth factor α transgenic mice

1998 • 197 citations

Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas

1992 • 169 citations

Nestin-Expressing Cells in the Pancreatic Islets of Langerhans

2000 • 164 citations

Insulin Secretion in Type 1 Diabetes

2004 • 162 citations

Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas

1998 • 161 citations

β-Cell Neogenesis During Prolonged Hyperglycemia in Rats

2002 • 160 citations

A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas

1983 • 142 citations

Nestin-Lineage Cells Contribute to the Microvasculature but Not Endocrine Cells of the Islet

2003 • 137 citations

Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth-related manner.

1990 • 106 citations

Potential Mechanisms by Which Certain Foods Promote or Inhibit the Development of Spontaneous Diabetes in BB Rats: Dose, Timing, Early Effect on Islet Area, and Switch in Infiltrate From Th1 to Th2 Cells

1997 • 104 citations

Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas

2004 • 100 citations

Tissue injury and repair as parallel and opposing responses to CCl4 hepatotoxicity: a novel dose-response

1997 • 98 citations

Origin of tubular complexes in human chronic pancreatitis

1982 • 93 citations

Origin and Development of the Precursor Lesions in Experimental Pancreatic Cancer in Rats

2003 • 92 citations

Cells of origin of pancreatic cancer: Experimental animal tumors related to human pancreas

1981 • 84 citations

Differentiation of pancreatic acinar cells into duct-like cells in vitro.

1993 • 76 citations

Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas

2003 • 73 citations

Immunohistochemical Characterization of Pancreatic Tumors Induced by Dimethylbenzanthracene in Rats

1999 • 61 citations

Activation of nestin‐positive duct stem (NPDS) cells in pancreas upon neogenic motivation and possible cytodifferentiation into insulin‐secreting cells from NPDS cells

2004 • 61 citations

Morphology of the exocrine pancreas related to pancreatitis

1997 • 56 citations

Islet Morphogenesis and Stem Cell Markers

2004 • 50 citations

Redifferentiation and apoptosis of pancreatic cells during acute pancreatitis

1996 • 39 citations

Toward Understanding Pancreatic Disease

1995 • 37 citations

Ontogeny of Hepatocyte Growth Factor and c-met/hgf Receptor in Rat Pancreas

1996 • 36 citations

Analysis of Expression Profiles of Islet-associated Transcription and Growth Factors During β-Cell Neogenesis from Duct Cells in Partially Duct-ligated Mice

2003 • 35 citations

Acinar cell apoptosis and the origin of tubular complexes in caerulein‐induced pancreatitis

1999 • 34 citations

Involution of the pancreas after ligation of the pancreatic ducts. I: a histological study.

1981 • 29 citations

Islet morphogenesis and stem cell markers

2004 • 28 citations

Expression of PGP9.5 in Ductal Cells of the Rat Pancreas during Development and Regeneration: Can It Be a Marker for Pancreatic Progenitor Cells?

2002 • 24 citations

Hydrolysed Casein Diet Protects BB Rats from Developing Diabetes by Promoting Islet Neogenesis

2000 • 21 citations

Differentiation of acinar cells into acinoductular cells in regenerating rat pancreas

2003 • 19 citations

Development of experimental cancer in the head of the pancreas by surgical induction of tissue injury

1984 • 15 citations

Bezafibrate, A Peroxisome Proliferator-activated Receptor (PPAR)-α Activator, Prevents Pancreatic Degeneration in Obese and Diabetic Rats

2003 • 14 citations

Increasedc-metExpression During Ductal β Cell Neogenesis in Experimental Autoimmune Diabetes

2001 • 8 citations