Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene Transcription in Pancreatic β Cells

Translating the Histone Code

2001 • 9,488 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets

2001 • 1,468 citations

Establishment of a Pancreatic β Cell Line That Retains Glucose-Inducible Insulin Secretion: Special Reference to Expression of Glucose Transporter Isoforms*

1990 • 1,212 citations

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

2002 • 1,176 citations

Histone acetylation and an epigenetic code

2000 • 1,164 citations

Cellular Memory and the Histone Code

2002 • 1,137 citations

MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters

2002 • 1,039 citations

Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

2000 • 877 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries

2001 • 746 citations

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

2000 • 741 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation

2002 • 555 citations

Histone Methylation

2002 • 525 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

Purification and Functional Characterization of a Histone H3-Lysine 4-Specific Methyltransferase

2001 • 511 citations

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin

2001 • 495 citations

Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells

2003 • 447 citations

Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin

2002 • 428 citations

Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells

2002 • 426 citations

Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.

1992 • 396 citations

Quantitative Assessment of Gene Targeting in Vitroand in Vivo by the Pancreatic Transcription Factor, Pdx1

2002 • 282 citations

Cell-free activation of a DNA-binding protein by epidermal growth factor

1993 • 263 citations

Histone H3 Lysine 4 Methylation Disrupts Binding of Nucleosome Remodeling and Deacetylase (NuRD) Repressor Complex

2002 • 247 citations

X-Inactivation and Histone H4 Acetylation in Embryonic Stem Cells

1996 • 244 citations

A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

1987 • 242 citations

Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells

2001 • 222 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 179 citations

Insulin Gene Transcription Is Mediated by Interactions between the p300 Coactivator and PDX-1, BETA2, and E47

2002 • 178 citations

Histone H3 Lysine 9 Methylation Occurs Rapidly at the Onset of Random X Chromosome Inactivation

2002 • 174 citations

Pdx1 restores β cell function in Irs2 knockout mice

2002 • 152 citations

Effects of histone acetylation on the equilibrium accessibility of nucleosomal DNA target sites 1 1Edited by R. Ebright

2001 • 152 citations

Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin

2002 • 144 citations

p300 Mediates Transcriptional Stimulation by the Basic Helix-Loop-Helix Activators of the Insulin Gene

1998 • 139 citations

Proglucagon Processing Similar to Normal Islets in Pancreatic α-Like Cell Line Derived From Transgenic Mouse Tumor

1990 • 134 citations

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.

1991 • 130 citations

PDX-1 Induces Differentiation of Intestinal Epithelioid IEC-6 Into Insulin-Producing Cells

2002 • 127 citations

Transcriptional Activation by Hepatocyte Nuclear Factor-1 Requires Synergism between Multiple Coactivator Proteins

2000 • 124 citations

Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast

2002 • 120 citations

Transcriptional Inhibition of Genes with Severe Histone H3 Hypoacetylation in the Coding Region

2002 • 120 citations

Transcription factors direct the development and function of pancreatic β cells

2003 • 119 citations

Structure of SET domain proteins: a new twist on histone methylation

2003 • 106 citations

Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain

2002 • 96 citations

Balance between Acetylation and Methylation of Histone H3 Lysine 9 on the E2F-Responsive Dihydrofolate Reductase Promoter

2003 • 93 citations

Cascade of Distinct Histone Modifications during Collagenase Gene Activation

2003 • 90 citations

Quantitative Analysis of the Hormone-induced Hyperacetylation of Histone H3 Associated with the Steroidogenic Acute Regulatory Protein Gene Promoter

2001 • 89 citations

Heritable chromatin structure: Mapping “memory” in histones H3 and H4

2002 • 83 citations

Murine pancreatic ductal adenocarcinoma produced by in vitro transduction of polyoma middle T oncogene into the islets of Langerhans.

1994 • 47 citations

Direct Association of p300 with Unmodified H3 and H4 N Termini Modulates p300-dependent Acetylation and Transcription of Nucleosomal Templates

2003 • 25 citations