Multifunctional Activities of Green Tea Catechins in Neuroprotection

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

Parkinson's Disease

2003 • 5,061 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

2004 • 3,278 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions

2003 • 1,796 citations

Iron, brain ageing and neurodegenerative disorders

2004 • 1,737 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

The metallobiology of Alzheimer's disease

2003 • 1,256 citations

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

2001 • 1,210 citations

Tea and Cancer

1993 • 1,012 citations

Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties

2004 • 996 citations

Hypoxia-inducible factor (HIF-1)α: its protein stability and biological functions

2004 • 969 citations

Oxidative stress and the pathogenesis of Parkinson's disease

1996 • 967 citations

Effects of Coenzyme Q10 in Early Parkinson Disease

2002 • 965 citations

Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease

2003 • 963 citations

Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms

2001 • 831 citations

Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections

2002 • 788 citations

Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes

1996 • 765 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

1994 • 701 citations

Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

2003 • 660 citations

Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

2003 • 613 citations

BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM

1997 • 596 citations

The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons

1999 • 581 citations

Green tea polyphenol (–)‐epigallocatechin‐3‐gallate prevents N‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced dopaminergic neurodegeneration

2001 • 557 citations

HIF1 and oxygen sensing in the brain

2004 • 539 citations

An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript

2002 • 530 citations

Commentary: Vitamin C: Antioxidant or Pro-Oxidant In Vivo?

1996 • 528 citations

Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue

1998 • 520 citations

Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

2004 • 488 citations

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.

2000 • 483 citations

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

2001 • 479 citations

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

1999 • 468 citations

Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models

2004 • 457 citations

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

1998 • 446 citations

The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity

2000 • 445 citations

Antioxidants and oxidants regulated signal transduction pathways

2002 • 437 citations

A mitochondrial perspective on cell death

2001 • 430 citations

Antioxidants in tea

1997 • 428 citations

Ginkgo Biloba Extract (EGb 761) and CNS Functions Basic Studies and Clinical Applications

2000 • 426 citations

Involvement of Protein Kinase C Activation and Cell Survival/ Cell Cycle Genes in Green Tea Polyphenol (−)-Epigallocatechin 3-Gallate Neuroprotective Action

2002 • 406 citations

ESR study on the structure–antioxidant activity relationship of tea catechins and their epimers

1999 • 401 citations

Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death

2000 • 399 citations

Nutritional approaches to combat oxidative stress in Alzheimer’s disease

2002 • 399 citations

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

1994 • 393 citations

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

2004 • 390 citations

Metal chelation of polyphenols

2001 • 383 citations

Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders

2004 • 377 citations

Parkinson's Disease Risks Associated with Cigarette Smoking, Alcohol Consumption, and Caffeine Intake

2002 • 370 citations

Neuroprotection and neurorescue against Aβ toxicity and PKC‐dependent release of non‐amyloidogenic soluble precursor protein by green tea polyphenol (‐)‐epigallocatechin‐3‐gallate

2003 • 369 citations

Uptake and metabolism of epicatechin and its access to the brain after oral ingestion

2002 • 360 citations

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases

2004 • 356 citations

Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

2004 • 352 citations

Worldwide Occurrence of Parkinson's Disease: An Updated Review

1993 • 339 citations

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

2002 • 338 citations

The green tea polyphenol (−)-epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons

2001 • 335 citations

A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

2004 • 329 citations

Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

2001 • 326 citations

Neuropathological spectrum of synucleinopathies

2003 • 324 citations

Green Tea Epigallocatechin-3-Gallate Mediates T Cellular NF-κB Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis

2004 • 312 citations

The Iron Chelator Desferrioxamine (Desferal) Retards 6‐Hydroxydopamine‐Induced Degeneration of Nigrostriatal Dopamine Neurons

1991 • 297 citations

Neuroprotective effects of resveratrol against β‐amyloid‐induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C

2004 • 291 citations

Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

2003 • 290 citations

Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

2002 • 284 citations

Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice.

1994 • 283 citations

Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by (−)-Epigallocatechin Gallate

2003 • 277 citations

Effects of pH and Metal Ions on Antioxidative Activities of Catechins

2001 • 270 citations

Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer’s, Parkinson’s, and other neurodegenerative diseases

2004 • 268 citations

Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3In Vivo

2000 • 260 citations

Protective effects of the green tea polyphenol (−)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils

2000 • 247 citations

Absorption and Distribution of Tea Catechin(-)-Epigallocatechin-3-Gallate, in the Rat.

1997 • 243 citations

Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease

1997 • 243 citations

Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

2003 • 241 citations

Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures

2004 • 240 citations

Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

2003 • 240 citations

Role of Cytochrome c as a Stimulator of α-Synuclein Aggregation in Lewy Body Disease

1999 • 229 citations

STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis

2004 • 222 citations

A Prevalence Survey of Parkinson's Disease and Other Movement Disorders in the People's Republic of China

1985 • 219 citations

Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson's disease

2002 • 219 citations

Hypoxic regulation of the 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase gene family (PFKFB‐1–4) expression in vivo

2003 • 218 citations

How Protein Kinase C Activation Protects Nerve Cells from Oxidative Stress-Induced Cell Death

2001 • 211 citations

Nitric oxide mediatesN-methyl-<scp>d</scp>-aspartate receptor-induced activation of p21^ras

1998 • 192 citations

α-synuclein implicated in Parkinson’s disease catalyses the formation of hydrogen peroxide in vitro

2001 • 185 citations

Neuroprotection via pro‐survival protein kinase C isoforms associated with Bcl‐2 family members

2004 • 185 citations

Protective effects of tea polyphenols against oxidative damage to red blood cells

1997 • 182 citations

Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspase-3 activation

2001 • 177 citations

Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils

2004 • 171 citations

Iron and α-Synuclein in the Substantia Nigra of MPTP-Treated Mice: Effect of Neuroprotective Drugs R-Apomorphine and Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate

2004 • 170 citations

Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression

1997 • 167 citations

Dual mechanisms of green tea extract‐induced cell survival in human epidermal keratinocytes

2003 • 164 citations

Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice

1997 • 162 citations

Green tea polyphenol (–)‐epigallocatechin‐3‐gallate induces neurorescue of long‐term serum‐deprived PC12 cells and promotes neurite outgrowth

2005 • 146 citations

Ubiquinone (Coenzyme Q&lt;sub&gt;10&lt;/sub&gt;) and Mitochondria in Oxidative Stress of Parkinson’s Disease

2001 • 145 citations

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

2004 • 140 citations

Neuroprotective effects of (−)‐epigallocatechin gallate after hypoxia‐ischemia‐induced brain damage: novel mechanisms of action

2004 • 138 citations

Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H₂O₂ and 6‐hydroxydopamine

1998 • 134 citations

Natural Phenolic Compounds as Cardiovascular Therapeutics: Potential Role of their Antiinflammatory Effects

2003 • 131 citations

Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson?s disease and other neurodegenerative diseases

2004 • 125 citations

Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases

2004 • 125 citations

cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells

2003 • 123 citations

Estrogen activates protein kinase C in neurons: role in neuroprotection

2003 • 117 citations

Iron-Mediated Degradation of IRP2, an Unexpected Pathway Involving a 2-Oxoglutarate-Dependent Oxygenase Activity

2004 • 117 citations

Green Tea Inhibits Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1α Activation

2004 • 110 citations

Essential role for integrin linked kinase in Akt‐mediated integrin survival signaling in hippocampal neurons

2003 • 104 citations

Epsilon Protein Kinase C Mediated Ischemic Tolerance Requires Activation of the Extracellular Regulated Kinase Pathway in the Organotypic Hippocampal Slice

2004 • 102 citations

Inhibition of the c-Jun N-Terminal Kinase Signaling Pathway by the Mixed Lineage Kinase Inhibitor CEP-1347 (KT7515) Preserves Metabolism and Growth of Trophic Factor-Deprived Neurons

2002 • 101 citations

Hereditary Causes of Disturbed Iron Homeostasis in the Central Nervous System

2004 • 99 citations

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

1999 • 89 citations

Tea Flavonoids: Bioavailability In Vivo and Effects on Cell Signaling Pathways In Vitro

2001 • 88 citations

Evidence that the Early Loss of Membrane Protein Kinase C Is a Necessary Step in the Excitatory Amino Acid‐Induced Death of Primary Cortical Neurons

1997 • 87 citations

Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species.

1999 • 86 citations

Involvement of amyloid precursor protein in functional synapse formation in cultured hippocampal neurons

1998 • 83 citations

Protective effects of green tea catechins on cerebral ischemic damage.

2004 • 80 citations

Pharmacological demonstration of the differential involvement of protein kinase C isoforms in short- and long-term memory formation and retrieval of one-trial avoidance in rats

2000 • 80 citations

Subacute myelo-optic neuropathy and clioquinol. An epidemiological case-history for diagnosis.

1975 • 76 citations

Direct Evidence of Interaction of a Green Tea Polyphenol, Epigallocatechin Gallate, with Lipid Bilayers by Solid-state Nuclear Magnetic Resonance

2004 • 73 citations

PKC α mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation

2004 • 72 citations

Effects of green tea polyphenols on dopamine uptake and on MPP+-induced dopamine neuron injury

2002 • 72 citations

cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson’s disease

2000 • 69 citations

Iron and neurodegeneration

1996 • 51 citations

Rasagiline: an anti-Parkinson drug with neuroprotective activity

2003 • 47 citations

Catechin attenuates 6-hydroxydopamine (6-OHDA)-induced cell death in primary cultures of mesencephalic cells

2003 • 46 citations

(-)-EPIGALLOCATECHIN GALLATE ATTENUATES GLUTAMATE-INDUCED CYTOTOXICITY VIA INTRACELLULAR CA2+ MODULATION IN PC12 CELLS

2004 • 46 citations

The efficacy of an antioxidant cocktail on lipid peroxide level and superoxide dismutase activity in aged rat brain and DNA damage in iron-induced epileptogenic foci

2000 • 37 citations

Phospholipase C, protein kinase C, Ca²⁺/calmodulin‐dependent protein kinase II, and redox state are involved in epigallocatechin gallate‐induced phospholipase D activation in human astroglioma cells

2004 • 26 citations

Neuroprotection in Parkinson’s disease: love story or mission impossible?

2002 • 22 citations

Nutritional Iron Deprivation Attenuates Kainate‐Induced Neurotoxicity in Rats: Implications for Involvement of Iron in Neurodegeneration

2004 • 20 citations

Apomorphine Is a Potent Radical Scavenger and Protects Cultured Pheochromocytoma Cells from 6-OHDA and H2O2-Induced Cell Death

1997 • 18 citations

Direct evidence of incorporation of 12-O-[20-2H1]tetradecanoylphorbol-13-acetate into artificial membranes as determined by deuterium magnetic resonance

1984 • 9 citations