Neuroprotection in Parkinson’s disease: love story or mission impossible?

Mitochondria and Apoptosis

1998 • 8,909 citations

Caspases: Enemies Within

1998 • 6,923 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

1990 • 2,147 citations

Aggresomes, inclusion bodies and protein aggregation

2000 • 1,881 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

2000 • 1,497 citations

ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE

1999 • 1,387 citations

Alpha-synuclein and neurodegenerative diseases

2001 • 1,339 citations

Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease

2000 • 1,255 citations

Effects of Tocopherol and Deprenyl on the Progression of Disability in Early Parkinson's Disease

1993 • 1,208 citations

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

2001 • 1,126 citations

Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

2001 • 1,036 citations

Cellular Defenses against Unfolded Proteins

2001 • 979 citations

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

2001 • 975 citations

Parkinson Disease in Twins<SUBTITLE>An Etiologic Study</SUBTITLE>

1999 • 861 citations

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

2001 • 775 citations

Proteasomal function is impaired in substantia nigra in Parkinson's disease

2001 • 631 citations

Experimental models of Parkinson's disease

2001 • 617 citations

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

2001 • 573 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

1999 • 545 citations

Failure of the ubiquitin–proteasome system in Parkinson's disease

2001 • 508 citations

Energetics in the pathogenesis of neurodegenerative diseases

2000 • 479 citations

[123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease.

1997 • 412 citations

The heterogeneity of Parkinson's disease

1985 • 361 citations

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

2001 • 360 citations

α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome

2001 • 350 citations

Fullerene-based antioxidants and neurodegenerative disorders

2001 • 333 citations

Human positron emission tomographic [¹⁸F]Fluorodopa studies correlate with dopamine cell counts and levels

1993 • 331 citations

Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models

1997 • 326 citations

The role of glial cells in Parkinsonʼs disease

2001 • 322 citations

The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins

1999 • 302 citations

A one-hit model of cell death in inherited neuronal degenerations

2000 • 299 citations

Complete Genomic Screen in Parkinson Disease

2001 • 289 citations

Excitotoxicity and nitric oxide in parkinson's disease pathogenesis

1998 • 285 citations

Caspase inhibition reduces apoptosis and increases survival of nigral transplants

1999 • 283 citations

Familial Aggregation of Parkinson's Disease in Iceland

2000 • 274 citations

Apoptosis in neurodegenerative diseases: the role of mitochondria

1999 • 253 citations

Pharmacological chaperones: a new twist on receptor folding

2000 • 238 citations

Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies

1996 • 235 citations

Parkinson Disease, the Effect of Levodopa, and the ELLDOPA Trial

1999 • 234 citations

Mitochondrial Membrane Potential and Nuclear Changes in Apoptosis Caused by Serum and Nerve Growth Factor Withdrawal: Time Course and Modification by (−)-Deprenyl

1998 • 232 citations

Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions

1998 • 223 citations

Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study

1995 • 221 citations

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

2001 • 221 citations

Enhanced vulnerability to oxidative stress by α-synuclein mutations and C-terminal truncation

2000 • 191 citations

Dopamine D2‐type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress

1998 • 191 citations

The Response of Subthalamic Nucleus Neurons to Dopamine Receptor Stimulation in a Rodent Model of Parkinson’s Disease

1997 • 184 citations

Protective Effects of the Antiparkinsonian Drugs Talipexole and Pramipexole against 1-Methyl-4-phenylpyridinium-Induced Apoptotic Death in Human Neuroblastoma SH-SY5Y Cells

1998 • 183 citations

Science, medicine, and the future: Parkinson's disease

1999 • 183 citations

Amantadine treatment is an independent predictor of improved survival in Parkinson's disease

1996 • 171 citations

α-Synuclein and the Lewy body disorders

2001 • 157 citations

Levodopa

1998 • 156 citations

Role of collateral flow on cerebral hemodynamics in patients with unilateral internal carotid artery occlusion

1998 • 154 citations

Familial parkinsonism with synuclein pathology

2001 • 148 citations

The Neurotoxicity of 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in the Monkey and Man

1984 • 142 citations

Epidemiology of Parkinsonʼs disease and akinetic syndromes

2000 • 135 citations

Dopamine agonists and neuroprotection in parkinson's disease

1998 • 130 citations

Neurodegeneration: a failure of neuroregeneration?

2001 • 115 citations

Effect of lazabemide on the progression of disability in early Parkinson's disease

1996 • 104 citations

A selective toxicity toward cultured mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation

1995 • 93 citations

Abnormal performance on the PD test battery by asymptomatic first-degree relatives

1999 • 92 citations

A possible role of coenzyme Q₁₀ in the etiology and treatment of Parkinson's disease

1999 • 91 citations

Mutant protein in Huntington disease is resistant to proteolysis in affected brain

2001 • 91 citations

Neuroimmunophilins: Novel neuroprotective and neuroregenerative targets

2001 • 82 citations

Mechanisms of cell death in neurodegenerative disorders

2000 • 82 citations

The causes of parkinson's disease are being unraveled and rational neuroprotective therapy is close to reality

1998 • 79 citations

Levodopa neurotoxicity

1998 • 74 citations

Parkinson's disease Improved function with GMl ganglioside treatment in a randomized placebo‐controlled study

1998 • 73 citations

A new link between pesticides and Parkinson's disease

2000 • 72 citations

Neuroprotective effects of D3 dopamine receptor agonists

2001 • 72 citations

Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale

1999 • 70 citations

Late‐onset neurodegenerative diseases—the role of protein insolubility

2000 • 61 citations

Glial cell line–derived neurotrophic factor–levodopa interactions and reduction of side effects in parkinsonian monkeys

1997 • 59 citations

CGP 3466 protects dopaminergic neurons in lesion models of Parkinson's disease

2000 • 54 citations

The novel anticonvulsant lamotrigine prevents dopamine depletion in C57 black mice in the MPTP animal model of Parkinson's disease

1994 • 52 citations

Future of neuroprotection in Parkinson's disease

2001 • 46 citations

Selegiline and mortality in Parkinson's disease

1996 • 44 citations

Attempts to obtain neuroprotection in Parkinson's disease

1997 • 44 citations

Novel observations with FDOPA‐PET imaging after early nigrostriatal damage

2001 • 40 citations

Neuropharmacologic aspects of apoptosis: significance for neurodegenerative diseases.

1999 • 36 citations

A multicenter randomized controlled trial of remacemide hydrochloride as monotherapy for PD

2000 • 33 citations

Neuroprotective Therapy for Parkinson's Disease

1997 • 30 citations

Apomorphine, a dopamine receptor agonist with remarkable antioxidant and cytoprotective properties.

1999 • 22 citations

Glia: a curtain raiser.

1999 • 13 citations

Assessing the integrity of the dopamine system in Parkinson's disease: How best to do it?

2001 • 7 citations

Is Parkinson's disease an inherited condition?

1999 • 7 citations

Detection of the human cytomegalovirus 2.0-kb immediate early gene 1 transcripts in permissive and nonpermissive infections by RNA in situ hybridization

1997 • 6 citations