Estrogen activates protein kinase C in neurons: role in neuroprotection

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

1996 • 1,640 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

2000 • 985 citations

A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease

1997 • 965 citations

Estrogen Therapy in Postmenopausal Women

1998 • 927 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury

1999 • 694 citations

Rapid actions of plasma membrane estrogen receptors

2001 • 649 citations

Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes

1996 • 633 citations

17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro

1995 • 612 citations

The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons

1999 • 581 citations

Estrogen for Alzheimer’s disease in women

2000 • 555 citations

ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury

2002 • 546 citations

Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

1998 • 545 citations

Neurotrophic and Neuroprotective Actions of Estrogens and Their Therapeutic Implications

2001 • 537 citations

Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations.

2001 • 537 citations

Neuroprotective effects of estrogens: potential mechanisms of action

2000 • 515 citations

Estrogen Replacement Therapy and Risk of Alzheimer Disease

1996 • 504 citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

1997 • 478 citations

Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways

1999 • 474 citations

Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors

1999 • 453 citations

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

1998 • 446 citations

Protein kinase C isozymes and substrates

1996 • 440 citations

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

1993 • 401 citations

Estrogen Modulates Neuronal Bcl‐x_l Expression and β‐Amyloid‐Induced Apoptosis

1999 • 390 citations

Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.

1994 • 365 citations

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

1997 • 325 citations

Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis

1997 • 308 citations

GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain

2002 • 279 citations

Estradiol upregulates Bcl-2 expression in adult brain neurons

1998 • 253 citations

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons

2000 • 242 citations

Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells

1996 • 238 citations

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.

1994 • 237 citations

Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways

1999 • 229 citations

Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester

1998 • 213 citations

How Protein Kinase C Activation Protects Nerve Cells from Oxidative Stress-Induced Cell Death

2001 • 211 citations

Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators.

1993 • 197 citations

CREB Phosphorylation Promotes Nerve Cell Survival

1999 • 189 citations

Phospholipase C β and Membrane Action of Calcitriol and Estradiol

1997 • 177 citations

Modulation of Bcl-2 expression

1998 • 173 citations

Mechanism of 17-β-Estradiol-induced Erk1/2 Activation in Breast Cancer Cells

2002 • 172 citations

Estrogen‐mediated neuroprotection against β‐amyloid toxicity requires expression of estrogen receptor α or β and activation of the MAPK pathway

2002 • 152 citations

Generation and Regulation of β‐Amyloid Peptide Variants by Neurons

1998 • 123 citations

Overexpression of Protein Kinase C Isoform  but not δ in Human Interleukin-3–Dependent Cells Suppresses Apoptosis and Induces bcl-2 Expression

1998 • 114 citations

Estrogen receptor-dependent regulation of sensory neuron survival in developing dorsal root ganglion

1999 • 112 citations

Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis.

1997 • 104 citations

Nongenomic regulation of protein kinase C isoforms by the vitamin D metabolites 1α,25-(OH)2D3 and 24R,25-(OH)2D3

1996 • 104 citations

Estrogens Cause Rapid Activation of IP3-PKC-α Signal Transduction Pathway in HEPG2 Cells

1998 • 88 citations

Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators

1993 • 87 citations

Estradiol Modulates Protein Kinase C Activity in the Rat Pituitary in Vivo and in Vitro

1990 • 85 citations

AVP-induced activation of MAP kinase in vascular smooth muscle cells is mediated through protein kinase C

1993 • 84 citations

17-beta-estradiol induces an inhibitor of active caspases.

2001 • 78 citations

Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures.

1998 • 73 citations

Preconditioning attenuates apoptosis and necrosis: role of protein kinase Cε and -δ isoforms

2001 • 70 citations

Estradiol Elevates Protein Kinase C Catalytic Activity in the Preoptic Area of Female Rats¹

1998 • 70 citations

Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase

1999 • 68 citations

17β-Estradiol regulation of protein kinase C activity in chondrocytes is sex-dependent and involves nongenomic mechanisms

1998 • 61 citations

17-β-Estradiol Induces an Inhibitor of Active Caspases

2001 • 58 citations

The membrane effects of 17β-estradiol on chondrocyte phenotypic expression are mediated by activation of protein kinase C through phospholipase C and G-proteins

2000 • 55 citations

The Phosphatidylinositol 3‐Kinase Inhibitor Wortmannin Alters the Metabolism of the Alzheimer's Amyloid Precursor Protein

1999 • 52 citations

Rapid filtration assays for protein kinase C activity andphorbol ester binding using multiwell plates with fitted filtration discs

1992 • 47 citations

Protein kinase C iota protects neural cells against apoptosis induced by amyloid β-peptide

2000 • 42 citations

Protein Phosphorylation Regulates Relative Utilization of Processing Pathways for Alzheimer β/A4 Amyloid Precursor Protein^a

1993 • 32 citations

Estrogen increases the expression of uterine protein kinase C isozymes in a tissue specific manner

1996 • 18 citations

Phorbol ester inhibits DNA damage-induced apoptosis in U937 cells through activation of protein kinase C

1999 • 15 citations

Modulation of a renal estrogen receptor by protein kinase C.

1994 • 6 citations