Neuroprotective effects of (−)‐epigallocatechin gallate after hypoxia‐ischemia‐induced brain damage: novel mechanisms of action

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

1981 • 2,073 citations

Green tea composition, consumption, and polyphenol chemistry

1992 • 1,866 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

Antioxidant Activity of Tea Polyphenols In Vivo: Evidence from Animal Studies

2003 • 945 citations

Role of angiogenesis in patients with cerebral ischemic stroke.

1994 • 820 citations

Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes

1996 • 765 citations

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

1996 • 713 citations

Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study

1996 • 708 citations

Nitric Oxide Synthase in Models of Focal Ischemia

1997 • 659 citations

Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene

1997 • 655 citations

Anoxic-ischemic encephalopathy in rats.

1960 • 644 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB.

1997 • 547 citations

Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate*

2000 • 513 citations

Dietary Flavonoids, Antioxidant Vitamins, and Incidence of Stroke

1996 • 506 citations

Inducible Nitric Oxide Synthase Gene Expression in Brain following Cerebral Ischemia

1995 • 479 citations

(−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB

1997 • 452 citations

Mitochondrial Generation of Reactive Oxygen Species After Brain Ischemia in the Rat

1996 • 390 citations

Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells

2001 • 379 citations

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases

2004 • 356 citations

Energy Thresholds in Brain Mitochondria

1998 • 354 citations

Rat model of perinatal hypoxic-ischemic brain damage

1999 • 350 citations

A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

2004 • 329 citations

Mitochondrial contributions to tissue damage in stroke

2002 • 320 citations

Targeting eNOS for stroke protection

2004 • 263 citations

Protective effects of the green tea polyphenol (−)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils

2000 • 247 citations

Inhibition of Inducible Nitric Oxide Synthase Gene Expression and Enzyme Activity by Epigallocatechin Gallate, a Natural Product from Green Tea

1997 • 245 citations

Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin

2004 • 222 citations

Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury

1996 • 192 citations

Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate

2000 • 183 citations

Protection against Nitric Oxide Toxicity by Tea

2000 • 177 citations

Neuroprotective Effects of the Green Tea Components Theanine and Catechins

2002 • 161 citations

Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production

1995 • 153 citations

Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis).

1998 • 137 citations

Oral administration of (-)catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil

1998 • 136 citations

Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis

2004 • 136 citations

Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury

2000 • 135 citations

Distinct Effects of Tea Catechins on 6-Hydroxydopamine-Induced Apoptosis in PC12 Cells

2002 • 132 citations

The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1

1999 • 128 citations

Columnar Alterations of NADH Fluorescence during Hypoxia-Ischemia in Immature Rat Brain

1982 • 123 citations

Alterations of human erythrocyte membrane fluidity by oxygen-derived free radicals and calcium

1990 • 117 citations

Green Tea Inhibits Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1α Activation

2004 • 110 citations

Antioxidant nutrients and hypoxia/ischemia brain injury in rodents

2003 • 109 citations

(−)-Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant

2002 • 104 citations

Possible contribution of green tea drinking habits to the prevention of stroke.

1989 • 103 citations

Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat.

1998 • 100 citations

Protective effect of green tea extract on ischemia/reperfusion-induced brain injury in Mongolian gerbils

2001 • 84 citations

Cerebroprotective Effect of the Nitric Oxide Synthase Inhibitors, 1-(2-Trifluoromethylphenyl) Imidazole and 7-Nitro Indazole, after Transient Focal Cerebral Ischemia in the Rat

1998 • 84 citations

Reoxygenation injury and antioxidant protection: A tale of two paradoxes

1990 • 81 citations

Protective effects of green tea catechins on cerebral ischemic damage.

2004 • 80 citations

Protective effect of green tea polyphenol (‐)‐epigallocatechin gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates

2003 • 80 citations

Ischemic injury to rat forebrain mitochondria and cellular calcium homeostasis

1992 • 75 citations

NADH Fluorescence and Regional Energy Metabolites during Focal Ischemia and Reperfusion of Rat Brain

1991 • 72 citations

Antioxidants, mitochondrial hyperoxidation and electrical recovery after anoxia in hippocampal slices

1997 • 71 citations

Cytochrome c oxidase and cardiolipin alterations in response to skeletal muscle ischaemia and reperfusion

1990 • 71 citations

Neuroprotective effects of spermine following hypoxia‐ischemia‐induced brain damage: A mechanistic study

2004 • 70 citations

Changes in intracellular free calcium concentration during long exposures to simulated ischemia in isolated mammalian ventricular muscle.

1992 • 67 citations

Mitochondrial Hyperoxidation Signals Residual Intracellular Dysfunction after Global Ischemia in Rat Neocortex

1995 • 61 citations

Different Effects of Five Catechins on 6-Hydroxydopamine-Induced Apoptosis in PC12 Cells

2001 • 47 citations

Green tea polyphenol (−)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats

2004 • 46 citations

Epigallocatechin gallate protects U937 cells against nitric oxide‐induced cell cycle arrest and apoptosis

2001 • 27 citations

Prolonged anoxic depolarization exacerbates NADH hyperoxidation and promotes poor electrical recovery after anoxia in hippocampal slices

1998 • 26 citations