The Pathogenesis of Atherosclerosis — An Update

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

The Pathogenesis of Atherosclerosis

1976 • 2,000 citations

Role of endothelium in responses of vascular smooth muscle.

1983 • 1,975 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Atherosclerosis and the Arterial Smooth Muscle Cell

1973 • 1,503 citations

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

1984 • 994 citations

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

1976 • 933 citations

Evidence for a Monoclonal Origin of Human Atherosclerotic Plaques

1973 • 900 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease

1984 • 764 citations

Hyperlipidemia and Atherosclerosis

1976 • 746 citations

Platelet-derived growth factor in chemotactic for fibroblasts.

1982 • 744 citations

Cultured endothelial cells produce heparinlike inhibitor of smooth muscle cell growth

1981 • 685 citations

Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium

1977 • 683 citations

Homocystinemia

1974 • 655 citations

The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering

1984 • 631 citations

The Macrophage as an Effector Cell

1980 • 628 citations

Platelets as a source of fibroblast growth-promoting activity

1974 • 625 citations

A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro.

1976 • 579 citations

Significance of quiescent smooth muscle migration in the injured rat carotid artery.

1985 • 570 citations

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.

1982 • 553 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Effect of Dipyridamole and Aspirin on Late Vein-Graft Patency after Coronary Bypass Operations

1984 • 529 citations

How LDL Receptors Influence Cholesterol and Atherosclerosis

1984 • 516 citations

Cultured endothelial cells produce a platelet-derived growth factor-like protein

1983 • 507 citations

Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1981 • 492 citations

Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats.

1983 • 487 citations

Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.

1984 • 470 citations

Defective Lipoprotein Receptors and Atherosclerosis

1983 • 469 citations

The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.

1981 • 468 citations

Platelet-derived growth factor. I. High yield purification and evidence for multiple forms.

1982 • 457 citations

George Lyman Duff Memorial Lecture. Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components.

1981 • 456 citations

Platelet alpha-granule proteins: studies on release and subcellular localization

1979 • 451 citations

Platelet factor 4 is chemotactic for neutrophils and monocytes.

1981 • 444 citations

Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens.

1981 • 443 citations

Platelet-derived growth factor: purification and partial characterization.

1979 • 436 citations

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

1981 • 427 citations

Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.

1983 • 414 citations

Dietary induced atherogenesis in swine. Morphology of the intima in prelesion stages.

1979 • 393 citations

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

1984 • 376 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

Developmentally regulated production of platelet-derived growth factor-like molecules

1984 • 368 citations

Platelet-derived growth factor. II. Specific binding to cultured cells.

1982 • 366 citations

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

1982 • 366 citations

Platelet alpha granules contain a growth factor for fibroblasts

1979 • 355 citations

Human platelet-derived growth factor. Purification and resolution into two active protein fractions.

1981 • 353 citations

Platelet‐derived growth factor is a chemoattractant for vascular smooth muscle cells

1982 • 340 citations

The fine structure of human atherosclerotic lesions.

1961 • 335 citations

Serum contains a platelet-derived transforming growth factor.

1982 • 330 citations

EXPERIMENTAL ARTERIOSCLEROSIS

1972 • 327 citations

Human atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery.

1984 • 320 citations

An endothelial cell-derived growth factor.

1980 • 316 citations

Endothelial regeneration. III. Time course of intimal changes after small defined injury to rat aortic endothelium.

1981 • 316 citations

Lipoproteins and atherosclerosis. A look back and a look ahead.

1983 • 315 citations

Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase.

1982 • 312 citations

Human Alveolar Macrophage Growth Factor for Fibroblasts

1982 • 301 citations

Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.

1982 • 293 citations

Biochemical studies of two patients with the gray platelet syndrome. Selective deficiency of platelet alpha granules.

1980 • 293 citations

The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.

1977 • 292 citations

Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor.

1981 • 283 citations

Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits

1958 • 270 citations

A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes.

1985 • 257 citations

Current View on the Mononuclear Phagocyte System

1982 • 248 citations

Expression of a Platelet-Derived Growth Factor-Like Protein in Simian Sarcoma Virus Transformed Cells

1983 • 246 citations

Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons.

1983 • 241 citations

Inhibition of Injury Induced Thromboatherosclerotic Lesions by Anti-Platelet Serum in Rabbits

1976 • 237 citations

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

1984 • 233 citations

THE GEOGRAPHIC PATHOLOGY OF ATHEROSCLEROSIS*

1968 • 227 citations

Expression of the sis gene by endothelial cells in culture and in vivo.

1984 • 221 citations

Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase.

1985 • 219 citations

Human platelet-derived growth factor (PDGF): purification of PDGF-I and PDGF-II and separation of their reduced subunits.

1981 • 211 citations

Aortic endothelial cell replication. I. Effects of age and hypertension in the rat.

1977 • 204 citations

Platelet-derived growth factor in vivo: levels, activity, and rate of clearance

1984 • 203 citations

Thromboatherosclerosis in normolipemic rabbits. A result of continued endothelial damage.

1973 • 200 citations

Human monocyte-derived growth factor(s) for mesenchymal cells: Activation of secretion by endotoxin and concanavalin A

1981 • 188 citations

Chemical and biological properties of a growth factor from human‐cultured osteosarcoma cells: Resemblance with platelet‐derived growth factor

1980 • 188 citations

Specific covalent binding of platelet-derived growth factor to human plasma alpha 2-macroglobulin.

1984 • 186 citations

Platelet-derived growth factor in vivo: levels, activity, and rate of clearance

1984 • 185 citations

Clustering of replicating cells in aortic endothelium.

1976 • 181 citations

Phenotype modulation in primary cultures of arterial smooth muscle cells

1984 • 173 citations

Fine structure of human aortic intimal thickening and fatty streaks.

1965 • 168 citations

Platelet-derived growth factor. Specific binding to target cells.

1982 • 163 citations

Control of monocyte recruitment by chemotactic factor(s) in lesion-prone areas of swine aorta.

1985 • 163 citations

Endothelial injury and regeneration. IV. Endotoxin: a nondenuding injury to aortic endothelium.

1983 • 161 citations

Regulation of production of a platelet‐derived growth factor‐like protein by cultured bovine aortic endothelial cells

1984 • 158 citations

Platelet-derived growth factor stimulates activity of low density lipoprotein receptors.

1980 • 156 citations

Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.

1983 • 147 citations

Characterization of the receptor for platelet-derived growth factor on human fibroblasts. Demonstration of an intimate relationship with a 185,000-Dalton substrate for the platelet-derived growth factor-stimulated kinase.

1983 • 144 citations

Dietary-induced atherosclerosis in miniature swine I. gross and light microscopy observations: Time of development and morphologic characteristics of lesions. II. Electron microscopy observations: Characteristics of endothelial and smooth muscle cells in the proliferative lesions and elsewhere in the aorta. III. Lipid values: Cholesterol, triglyceride and phospholipid, and esterified fatty acid values in serum and in aortic intima-media tissue. IV. Metabolic studies: In vitro protein synthesis …

1968 • 142 citations

Endothelial integrity and viability in the aorta of the normal rabbit and rat as evaluated with dye exclusion tests and interference contrast microscopy

1972 • 138 citations

Synthesis of Connective Tissue Macromolecules by Smooth Muscle

1979 • 128 citations

Characterization of the adhesion of the human monocytic cell line U937 to cultured endothelial cells.

1985 • 123 citations

George Lyman Duff memorial lecture. Persistent problems in the pathogenesis of atherosclerosis.

1984 • 114 citations

Endothelial surface characteristics in pigeon coronary artery atherosclerosis. I. Cellular alterations during the initial stages of dietary cholesterol challenge.

1982 • 114 citations

Endothelial regeneration. VII. Lack of intimal proliferation after defined injury to rat aorta.

1985 • 111 citations

Plasma binding proteins for platelet-derived growth factor that inhibit its binding to cell-surface receptors.

1984 • 95 citations

Role of stimulation of arachidonic acid release in the proliferative response of 3T3 mouse fibroblasts to platelet‐derived growth factor

1982 • 91 citations

Early atherogenesis in White Carneau pigeons. I. Leukocyte margination and endothelial alterations at the celiac bifurcation.

1984 • 90 citations

Human arterial wall cells secrete factors that are chemotactic for monocytes.

1983 • 88 citations

Ultrastructural studies on the localization of IgG in the aortic endothelium and subendothelial intima of atherosclerotic and nonatherosclerotic rabbits

1980 • 85 citations

Association of DNA synthesis and apparent dedifferentiation of aortic smooth muscle cells in vitro

1970 • 81 citations

The role of membrane-membrane interactions in the regulation of endothelial cell growth.

1985 • 80 citations

Coronary heart disease: genetic aspects.

1983 • 78 citations

Dissociation of the chemotactic and mitogenic activities of platelet-derived growth factor by human neutrophil elastase.

1985 • 77 citations

Recent advances in molecular pathology: A review

1967 • 76 citations

Biochemical properties of the endothelium‐derived growth factor: Comparision to other growth factors

1983 • 75 citations

Kinetics of Atherosclerosis: A Stem Cell Model

1985 • 70 citations

Human atherosclerotic plaque cells and leiomyoma cells. Comparison of in vitro growth characteristics.

1975 • 69 citations

Density-dependent regulation of cell growth: An example of a cell-cell recognition phenomenon

1981 • 68 citations

From the Author

1984 • 67 citations

Expression of the PDGF-related transforming protein of simian sarcoma virus in E. coli

1984 • 65 citations

Hyperlipidemia and Coronary Atherosclerosis

1981 • 62 citations

Platelet-derived growth factor stimulates low density lipoprotein receptor activity in cultured human fibroblasts.

1980 • 61 citations

The effect of hypercholesterolemia on aortic endothelium studied en face

1975 • 61 citations

Appearance in confluent vascular endothelial cell monolayers of a specific cell surface protein (CSP-60) not detected in actively growing endothelial cells or in cell types growing in multiple layers.

1979 • 59 citations

Production of Growth Factor Activity for Fibroblasts by Human Monocyte-Derived Macrophages

1984 • 52 citations

Recent advances in molecular pathology

1984 • 52 citations

Platelet adhesion and myointimal proliferation in canine pulmonary arteries.

1981 • 43 citations

The Platelet-Derived Growth Factor Receptor

1985 • 40 citations

Generation of a unique fibroblast-activating factor by human monocytes.

1984 • 35 citations

Is epidermal growth factor present in human blood? Interference with the radioreceptor assay for epidermal growth factor

1983 • 32 citations

Pulmonary vascular response during phases of canine heartworm disease: scanning electron microscopic study.

1980 • 31 citations

Atherosclerosis: a question of endothelial integrity and growth control of smooth muscle.

1981 • 28 citations

Perianastomotic arteriosclerosis in grafted human coronary arteries: Prevention with platelet-inhibiting therapy

1982 • 10 citations