Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method

1979 • 1,477 citations

Plasma lipoproteins: apolipoprotein structure and function.

1984 • 1,130 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes

1987 • 773 citations

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

1987 • 625 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

1978 • 621 citations

Free radicals, lipids and protein degradation

1986 • 556 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Lipoprotein oxidation and lipoprotein-induced cytotoxicity.

1983 • 545 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

1986 • 516 citations

LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture

1979 • 512 citations

The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis

1986 • 492 citations

Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism.

1987 • 473 citations

Enhanced macrophage degradation of biologically modified low density lipoprotein.

1983 • 469 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 417 citations

The Relationship Between Plasma and Tissue Lipids in Human Atherosclerosis

1974 • 356 citations

Altered Metabolism (In Vivo and In Vitro) of Plasma Lipoproteins after Selective Chemical Modification of Lysine Residues of the Apoproteins

1979 • 313 citations

Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes.

1981 • 293 citations

Superoxide initiates oxidation of low density lipoprotein by human monocytes.

1987 • 273 citations

Unequivocal demonstration that malondialdehyde is a mutagen

1983 • 269 citations

Effect of polyunsaturated fatty acids and antioxidants on lipid peroxidation in tissue cultures.

1981 • 252 citations

Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal

1986 • 241 citations

Oxidation of low-density lipoprotein by thiol compounds leads to its recognition by the acetyl LDL receptor

1987 • 236 citations

The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron

1983 • 234 citations

Injury to human endothelial cells in culture induced by low density lipoproteins

1979 • 231 citations

Inhibition of cell growth by oxygenated derivatives of cholesterol

1974 • 219 citations

Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells.

1985 • 219 citations

Role of lysines in mediating interaction of modified low density lipoproteins with the scavenger receptor of human monocyte macrophages.

1984 • 213 citations

The accumulation of malonyldialdehyde, a product of fatty acid peroxidation, can disturb aminophospholipid organization in the membrane bilayer of human erythrocytes.

1984 • 196 citations

Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor

1978 • 171 citations

Identification of NaK-ATPase inhibitors in human plasma as nonesterified fatty acids and lysophospholipids.

1986 • 167 citations

Possible involvement of the lipid-peroxidation product 4-hydroxynonenal in the formation of fluorescent chromolipids

1986 • 166 citations

Cholesterol oxidation derivatives and arterial endothelial damage

1985 • 165 citations

Role of endothelial cells and their products in the modification of low-density lipoproteins

1986 • 159 citations

Cytotoxic aldehydes originating from the peroxidation of liver microsomal lipids

1984 • 150 citations

The chemistry of lipid peroxidation metabolites: Crosslinking reactions of malondialdehyde

1986 • 148 citations

Isolation, purification, and characterization of a lipoprotein containing apo B from the human aorta

1982 • 135 citations

The effect of malonyldialdehyde, a product of lipid peroxidation, on the deformability, dehydration and ⁵¹Cr‐survival of erythrocytes

1983 • 130 citations

Cytotoxicity, thiol depletion and inhibition of O⁶-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts

1985 • 122 citations

Chemotactic Activity of the Lipid Peroxidation Product 4-Hydroxynonenal and Homologous Hydroxyalkenals

1986 • 120 citations

INTERACTIONS OF PLASMA LIPOPROTEINS WITH ENDOTHELIAL CELLS*

1982 • 114 citations

Toxicity of oxidized low‐density lipoprotein to cultured fibroblasts is selective for S phase of the cell cycle

1987 • 112 citations

Effects of the lipidperoxidation product 4-hydroxynonenal and related aldehydes on proliferation and viability of cultured ehrlich ascites tumor cells

1985 • 109 citations

Cholesterol esterification in macrophages. Stimulation by lipoproteins containing apo B isolated from human aortas.

1984 • 107 citations

Sites and mechanisms of uptake and degradation of high density and low density lipoproteins

1984 • 102 citations

Metabolism of normal and modified low-density lipoproteins by macrophage cell lines of murine and human origin

1985 • 97 citations

Malondialdehyde formation in stored plasma

1980 • 97 citations

Age-Dependent Changes in Lipid Peroxide Levels in the Lipoprotein Fractions of Human Serum

1984 • 91 citations

Effect of malonaldehyde and acetaldehyde on cultured mammalian cells

1982 • 90 citations

Low density lipoproteins (LDL) are carriers for lipid peroxides and inhibit prostacyclin (PGI2) biosynthesis in arteries.

1980 • 89 citations

A low density lipoprotein-sized particle isolated from human atherosclerotic lesions is internalized by macrophages via a non-scavenger-receptor mechanism.

1990 • 87 citations

Lipoprotein-mediated inhibition of endothelial cell production of platelet-derived growth factor-like protein depends on free radical lipid peroxidation.

1987 • 87 citations

Connective tissue responses to oxysterols

1982 • 85 citations

The distribution of ceroid in human atherosclerosis

1985 • 79 citations

Enhanced rates of fluid pinocytosis during exponential growth and monolayer regeneration by cultured arterial endothelial cells

1980 • 78 citations

EVOLUTION OF THE LDL RECEPTOR CONCEPT–FROM CULTURED CELLS TO INTACT ANIMALS *

1980 • 78 citations

In vivo catabolism of biologically modified LDL.

1984 • 74 citations

Comparison of the Inactivation of Microsomal Glucose-6-Phosphatase by in Situ Lipid Peroxidation-Derived 4-Hydroxynonenal and Exogenous 4-Hydroxynonenal

1986 • 70 citations

Apolipoprotein B retention in the grossly normal and atherosclerotic human aorta.

1977 • 67 citations

Oxidized low density lipoprotein induces ceroid accumulation by murine peritoneal macrophages in vitro

1986 • 66 citations

Chemotactic activity of hydroxyalkenals on rat neutrophils.

1985 • 62 citations

Processing of acetylated human low-density lipoprotein by parenchymal and non-parenchymal liver cells. Involvement of calmodulin?

1982 • 61 citations

Injury to cultured endothelial cells induced by low density lipoproteins: protection by high density lipoproteins

1979 • 60 citations

Endocytosis and chloroquine accumulation during the cell cycle of hepatoma cells in culture.

1979 • 60 citations

25-Hydroxysterols increase the permeability of liposomes to Ca2+ and other cations

1984 • 57 citations

Fluorescent products of lipid peroxidation: II. Methods for analysis and characterization

1974 • 55 citations

Lipoproteins and lipoprotein metabolism

1983 • 54 citations

The inhibitory effect of 4‐hydroxy‐nonenal on DNA‐polymerases alpha and beta from rat liver and rapidly dividing Yoshida ascites hepatoma

1986 • 52 citations

The steatotic and cytotoxic effects of cholesterol oxides in cultured L cells

1984 • 49 citations

Investigation of human plasma low density lipoprotein by three‐dimensional flourescence spectroscopy

1986 • 49 citations

The interaction of carbamylated low-density lipoprotein with cultured cells

1983 • 48 citations

Lipid peroxides and alpha-tocopherol in rat streptozotocin-induced diabetes mellitus.

1982 • 47 citations

Inhibition of lymphocyte mitogenesis by autoxidized low-density lipoprotein

1978 • 46 citations

Fluorescent and cross-linked proteins of human erythrocyte ghosts formed by reaction with hydroperoxylinoleic acid, malonaldehyde and monofunctional aldehydes.

1986 • 46 citations

Interaction of 4-hydroxynonenal-modified low-density lipoproteins with the fibroblast apolipoprotein B/E receptor

1986 • 45 citations

Transport of α-and γ-tocopherol in human plasma lipoproteins

1985 • 41 citations

Investigation of Lipid Peroxidation in Human Low Density Lipoprotein

1987 • 37 citations

Determination of malondialdehyde-DNA crosslinks by fluorescence and incorporation of tritium

1981 • 37 citations

Toxicity of free fatty acids for cultured rat heart muscle and endothelioid cells. II. Unsaturated long-chain fatty acids

1978 • 34 citations

THE FINE STRUCTURE OF CEROID IN HUMAN ATHEROMA

1967 • 30 citations

Fluorescent pigments by covalent binding of lipid peroxidation by‐products to protein and amino acids

1985 • 28 citations

Physical and chemical changes in isolated chylomicrons: prevention by EDTA

1970 • 28 citations

Toxicity of free fatty acids for cultured rat heart muscle and endothelioid cells. I. Saturated long-chain fatty acids

1978 • 26 citations

Mechanism of Human Erythrocyte Hemolysis Induced by Short-Chain Phosphatidylcholines and Lysophosphatidylcholine1

1983 • 25 citations

Changes of apolipoprotein B molecular weight and immunoreactivity in malondialdehyde-modified low density lipoproteins.

1983 • 25 citations

High-affinity uptake and degradation of acetylated low density lipoprotein by confluent human vascular endothelial cells

1985 • 21 citations

Oxidized low density lipoprotein can reduce the pinocytic activity in cultured human endothelial cells as measured by cellular uptake of [14C]sucrose

1985 • 20 citations

Nucleosome repeat structure is present in native salivary chromosomes of Drosophila melanogaster.

1982 • 19 citations

Cytotoxicity of thermally oxidized fats

1981 • 18 citations

Reaction of malonaldehyde with mitochondrial membranes

1982 • 14 citations

Injury to human cells in culture induced by low density lipoprotein: An effect independent of receptor binding and endocytotic uptake of low density lipoprotein

1982 • 14 citations

Injury to human cells in culture induced by low density lipoprotein: An effect independent of receptor binding and endocytotic uptake of low density lipoprotein

1982 • 14 citations

The role of fatty acids in ischemic tissue injury: difference between oleic and palmitic acid

1986 • 12 citations

Inhibition of Macrophage-Mediated Tumor Cell Destruction by Oxidized Lipoproteins2

1984 • 7 citations

Cell-cell contact and growth regulation of pinocytosis in 3T3 cells

1980 • 7 citations

Spatial organization of low-density lipoproteins of the human aorta (a fluorescent probe study)

1983 • 4 citations