RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Geometric Control of Cell Life and Death

1997 • 4,614 citations

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

1998 • 3,843 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

Cell Movement Is Guided by the Rigidity of the Substrate

2000 • 3,179 citations

RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS

1996 • 3,074 citations

Taking Cell-Matrix Adhesions to the Third Dimension

2001 • 2,940 citations

Alginate hydrogels as synthetic extracellular matrix materials

1999 • 2,230 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Adsorption of proteins onto surfaces containing end-attached oligo(ethylene oxide): a model system using self-assembled monolayers

1993 • 1,605 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1997 • 1,400 citations

Ligand Binding to Integrins

2000 • 1,332 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Molecular modeling of protein-glycosaminoglycan interactions.

1989 • 1,288 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

1997 • 1,218 citations

Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3α,6α-diphenyl glycoluril (Iodogen)

1981 • 1,135 citations

Molecular complexity and dynamics of cell-matrix adhesions

2001 • 1,091 citations

Biomaterials in Tissue Engineering

1995 • 1,061 citations

Function and interactions of integrins

2001 • 1,018 citations

Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering

2002 • 977 citations

Cell adhesion and motility depend on nanoscale RGD clustering

2000 • 932 citations

Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing

1998 • 902 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation.

1991 • 870 citations

N-Methylated Cyclic RGD Peptides as Highly Active and Selective α_Vβ₃Integrin Antagonists

1999 • 803 citations

The structural and mechanical complexity of cell-growth control

1999 • 769 citations

An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines

1975 • 748 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

Biomaterials in Drug Delivery and Tissue Engineering: One Laboratory's Experience

1999 • 735 citations

Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts

2001 • 724 citations

A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis

1990 • 710 citations

Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering

2001 • 691 citations

Surface modification of polymers for medical applications

1994 • 657 citations

Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion.

1987 • 653 citations

Modulation of Cell Proliferation and Differentiation through Substrate-dependent Changes in Fibronectin Conformation

1999 • 649 citations

The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

1994 • 617 citations

Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength

1993 • 603 citations

Structural and Functional Aspects of RGD-Containing Cyclic Pentapeptides as Highly Potent and Selective Integrin α_Vβ₃Antagonists

1996 • 571 citations

Extracellular matrix and integrin signalling: the shape of things to come

1999 • 567 citations

Assembly and mechanosensory function of focal contacts

2001 • 548 citations

A reevaluation of integrins as regulators of angiogenesis

2002 • 546 citations

Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering

2002 • 546 citations

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

2001 • 544 citations

Arg‐Gly‐Asp constrained within cyclic pentapoptides Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1

1991 • 543 citations

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

1993 • 537 citations

Cell-interactive Alginate Hydrogels for Bone Tissue Engineering

2001 • 532 citations

Surface Treatments of Polymers for Biocompatibility

1996 • 530 citations

Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.

1994 • 527 citations

Synthetic multivalent ligands in the exploration of cell-surface interactions

2000 • 518 citations

Surface modification of neural recording electrodes with conducting polymer/biomolecule blends

2001 • 514 citations

Protein adsorption on solid surfaces

1996 • 503 citations

Bioactive biomaterials

1999 • 462 citations

Synthesis and RGD peptide modification of a new biodegradable copolymer: poly(lactic acid-co-lysine)

1993 • 458 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion.

1986 • 442 citations

Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin.

1980 • 441 citations

RGD peptides induce apoptosis by direct caspase-3 activation

1999 • 432 citations

A pentapeptide from the laminin B1 chain mediates cell adhesion and binds to 67000 laminin receptor

1987 • 431 citations

Conjugate Addition Reactions Combined with Free-Radical Cross-Linking for the Design of Materials for Tissue Engineering

2001 • 408 citations

Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus

2002 • 408 citations

Alginate type and RGD density control myoblast phenotype

2002 • 406 citations

Physical State of the Extracellular Matrix Regulates the Structure and Molecular Composition of Cell-Matrix Adhesions

2000 • 402 citations

Engineering growing tissues

2002 • 392 citations

Convalent surface immobilization of Arg-Gly-Asp- and Tyr-Ile-Gly-Ser-Arg-containing peptides to obtain well-defined cell-adhesive substrates

1990 • 390 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Focal adhesions: Structure and dynamics

2000 • 380 citations

Strength in numbers: non-natural polyvalent carbohydrate derivatives

1996 • 375 citations

Endothelial Cell-Selective Materials for Tissue Engineering in the Vascular Graft Via a New Receptor

1991 • 367 citations

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.

1996 • 365 citations

Studies on the biocompatibility of materials: Fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability

1996 • 356 citations

Integrin signaling revisited

2001 • 355 citations

Focal Adhesion Motility Revealed in Stationary Fibroblasts

1999 • 345 citations

Biomimetic Peptide Surfaces That Regulate Adhesion, Spreading, Cytoskeletal Organization, and Mineralization of the Matrix Deposited by Osteoblast-like Cells

1999 • 344 citations

Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension

2000 • 334 citations

Biologically Engineered Protein-graft-Poly(ethylene glycol) Hydrogels: A Cell Adhesive and Plasmin-Degradable Biosynthetic Material for Tissue Repair

2002 • 315 citations

Conformation/activity studies of rationally designed potent anti‐adhesive RGD peptides

1992 • 314 citations

Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial

1997 • 313 citations

Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds

2002 • 309 citations

Extracellular Matrix Cell Adhesion Peptides: Functional Applications in Orthopedic Materials

2000 • 309 citations

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library

1994 • 308 citations

Surface Coating with Cyclic RGD Peptides Stimulates Osteoblast Adhesion and Proliferation as well as Bone Formation

2000 • 306 citations

Cross-Linking Exogenous Bifunctional Peptides into Fibrin Gels with Factor XIIIa

1998 • 306 citations

Using Mixed Self-Assembled Monolayers Presenting RGD and (EG)₃OH Groups To Characterize Long-Term Attachment of Bovine Capillary Endothelial Cells to Surfaces

1998 • 304 citations

Human endothelial cell interactions with surface‐coupled adhesion peptides on a nonadhesive glass substrate and two polymeric biomaterials

1991 • 297 citations

RGD-coated titanium implants stimulate increased bone formation in vivo

1999 • 284 citations

Human osteoprogenitor growth and differentiation on synthetic biodegradable structures after surface modification

2001 • 277 citations

A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin.

1993 • 264 citations

Tissue Engineers Build New Bone

2000 • 263 citations

Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid‐Phase Peptide Synthesis and Chemoselective Oxime Ligation

2003 • 262 citations

Design and function of novel osteoblast-adhesive peptides for chemical modification of biomaterials

1998 • 256 citations

Direct Measurement of a Tethered Ligand-Receptor Interaction Potential

1997 • 256 citations

Cell migration through defined, synthetic extracellular matrix analogues

2002 • 255 citations

Thermo-Responsive Peptide-Modified Hydrogels for Tissue Regeneration

2001 • 253 citations

Strength in Numbers?

2002 • 246 citations

Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin αvβ5-directed Cell Migration

1996 • 244 citations

Complexity and specificity of integrin signalling

2000 • 244 citations

Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion

1993 • 235 citations

Functional Biomaterials: Design of Novel Biomaterials

2001 • 234 citations

Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking of protecting groups in peptide synthesis

1989 • 232 citations

Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition

1999 • 230 citations

Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation.

1988 • 228 citations

Poly(l-lysine)–GRGDS as a biomimetic surface modifier for poly(lactic acid)

2001 • 223 citations

Surface-immobilized dextran limits cell adhesion and spreading

2000 • 221 citations

Cell alignment is induced by cyclic changes in cell length: studies of cells grown in cyclically stretched substrates

2001 • 218 citations

Impact of Polymer Tether Length on Multiple Ligand-Receptor Bond Formation

2001 • 217 citations

Effects of Modifications of the RGD Sequence and Its Context on Recognition by the Fibronectin Receptor

1989 • 213 citations

Syndecan-4 and focal adhesion function

2001 • 209 citations

Copolymerization and Degradation of Poly(lactic acid-co-lysine)

1995 • 207 citations

Extracellular Matrix-derived Peptide Binds to αvβ3 Integrin and Inhibits Angiogenesis

2001 • 205 citations

Immobilized RGD peptides on surface-grafted dextran promote biospecific cell attachment

2001 • 203 citations

Regulation of human osteoblast integrin expression by orthopedic implant materials

1996 • 203 citations

A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation.

1993 • 202 citations

Surface modification for controlled studies of cell–ligand interactions

1999 • 201 citations

Integrin expression in human melanoma cells with differing invasive and metastatic properties

1992 • 197 citations

Spinal cord repair with PHPMA hydrogel containing RGD peptides (NeuroGel™)

2001 • 194 citations

Cell migration as a five-step cycle.

1999 • 193 citations

Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin.

1993 • 192 citations

Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 Integrins

2002 • 192 citations

Coming to grips with integrin binding to ligands

2002 • 190 citations

Extracellular matrix–integrin interactions in osteoblast function and tissue remodeling

1999 • 189 citations

Polymer Networks with Grafted Cell Adhesion Peptides for Highly Biospecific Cell Adhesive Substrates

1994 • 189 citations

Bioactivation of Metal Oxide Surfaces. 1. Surface Characterization and Cell Response

1999 • 187 citations

Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

1997 • 184 citations

Cell Locomotion and Focal Adhesions Are Regulated by the Mechanical Properties of the Substrate

1998 • 183 citations

Modulation of marrow stromal osteoblast adhesion on biomimetic oligo[poly(ethylene glycol) fumarate] hydrogels modified with Arg‐Gly‐Asp peptides and a poly(ethylene glycol) spacer

2002 • 182 citations

Designing Biomaterials to Direct Biological Responses

1999 • 180 citations

β1 And β3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrix

1992 • 179 citations

The effect of peptide surface density on mineralization of a matrix deposited by osteogenic cells

2000 • 178 citations

Focal adhesion sites and the removal of substratum-bound fibronectin.

1986 • 176 citations

Synthesis, surface, and cell‐adhesion properties of polyurethanes containing covalently grafted RGD‐peptides

1994 • 176 citations

Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 1. Synthesis and Characterization of Comb Thin Films

2000 • 175 citations

Inhibition of Cell Adhesion to Fibronectin by Oligopeptide-Substituted Polynorbornenes

2001 • 175 citations

Extracellular matrix and integrin signalling: the shape of things to come

1999 • 174 citations

Effects of polystyrene surface chemistry on the biological activity of solid phase fibronectin and vitronectin, analysed with monoclonal antibodies

1993 • 174 citations

Fibronectin adsorption, conformation, and orientation on polystyrene substrates studied by radiolabeling, XPS, and ToF SIMS

1998 • 173 citations

Covalent attachment of an Arg-Gly-Asp sequece peptide to derivatizable polyacrylamide surfaces: Support of fibroblast adhesion and long-term growth

1988 • 170 citations

Synthesis, analytical characterization, and osteoblast adhesion properties on RGD-grafted polypyrrole coatings on titanium substrates

2000 • 169 citations

Covalently Attached GRGD on Polymer Surfaces Promotes Biospecific Adhesion of Mammalian Cells^a

1990 • 167 citations

The Structures of Integrins and Integrin–Ligand Complexes: Implications for Drug Design and Signal Transduction

2002 • 167 citations

Effect of receptor-ligand affinity on the strength of endothelial cell adhesion

1996 • 166 citations

Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to platelets

1987 • 165 citations

Proteinlike molecular architecture: Biomaterial applications for inducing cellular receptor binding and signal transduction

1998 • 165 citations

Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates

1997 • 163 citations

A novel method for surface modification to promote cell attachment to hydrophobic substrates

1998 • 160 citations

Immobilized Arg-Gly-Asp (RGD) peptides of varying lengths as structural probes of the platelet glycoprotein IIb/IIIa receptor

1992 • 158 citations

Multiple Roles of Integrins in Cell Motility

2000 • 158 citations

Three-dimensional extracellular matrix engineering in the nervous system

1998 • 158 citations

Three-dimensional Migration of Neurites Is Mediated by Adhesion Site Density and Affinity

2000 • 156 citations

Effect of RGD peptide coating of titanium implants on periimplant bone formation in the alveolar crest

2002 • 156 citations

Materials for enhancing cell adhesion by immobilization of cell‐adhesive peptide

1991 • 155 citations

Improved endothelial cell attachment on ePTFE vascular grafts pretreated with synthetic RGD-containing peptides

1996 • 154 citations

A Novel Family of Cyclic Peptide Antagonists Suggests That N-cadherin Specificity Is Determined by Amino Acids That Flank the HAV Motif

2000 • 154 citations

Galactosylated alginate as a scaffold for hepatocytes entrapment

2002 • 148 citations

Endothelial cell adhesion on polyurethanes containing covalently attached RGD-peptides

1992 • 147 citations

Orthogonal ligation strategies for peptide and protein

1999 • 146 citations

Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II

1995 • 144 citations

Integrin subunits responsible for adhesion of human osteoblast‐like cells to biomimetic peptide surfaces

1999 • 143 citations

A Hydrogel Material for Plastic and Reconstructive Applications Injected into the Subcutaneous Space of a Sheep

2002 • 142 citations

Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin .alpha.IIb.beta.3 antagonists

1994 • 141 citations

Simulations of Cell-Surface Integrin Binding to Nanoscale-Clustered Adhesion Ligands

2002 • 140 citations

Biological roles of the non-integrin elastin/laminin receptor.

1996 • 137 citations

Peptide, protein, and cellular interactions with self‐assembled monolayer model surfaces

1993 • 137 citations

Fibronectin modulates macrophage adhesion and FBGC formation: The role of RGD, PHSRN, and PRRARV domains

2001 • 133 citations

Conditions which promote mineralization at the bone-implant interface: a model in vitro study

1996 • 131 citations

RGD-peptides for tissue engineering of articular cartilage

2002 • 129 citations

Cell adhesion and growth on synthetic elastomeric matrices containing ARG‐GLY–ASP–SER–³

1992 • 129 citations

Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 2. Surface Segregation of Comb Polymers in Polylactide

2001 • 129 citations

Development of a hybrid cardiovascular graft using a tissue engineering approach ¹

2002 • 129 citations

[2] Immobilization of ligands with organic sulfonyl chlorides

1984 • 128 citations

Precoating substrate and surface configuration determine adherence and spreading of seeded endothelial cells on polytetrafluoroethylene grafts

1989 • 128 citations

Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells.

2002 • 126 citations

Creating biomimetic micro-environments with synthetic polymer-peptide hybrid molecules

1998 • 123 citations

Patterned glass surfaces direct cell adhesion and process outgrowth of primary neurons of the central nervous system

1998 • 122 citations

Cell‐Type‐Specific adhesion mechanisms mediated by fibronectin adsorbed to chemically derivatized substrata

1992 • 122 citations

Selective RGD-Mediated Adhesion of Osteoblasts at Surfaces of Implants

1999 • 118 citations

Bone Sialoprotein Mediates Human Endothelial Cell Attachment and Migration and Promotes Angiogenesis

2000 • 118 citations

A novel biotinylated degradable polymer for cell-interactive applications

1998 • 116 citations

The 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl group (Pbf) as arginine side chain protectant

1993 • 116 citations

Soft-Tissue Augmentation with Injectable Alginate and Syngeneic Fibroblasts

2000 • 115 citations

Chimeric Peptides of Statherin and Osteopontin That Bind Hydroxyapatite and Mediate Cell Adhesion

2000 • 115 citations

Understanding the molecules of neural cell contacts: emerging patterns of structure and function

1989 • 114 citations

β ₃ -Integrins Rather Than β ₁ -Integrins Dominate Integrin-Matrix Interactions Involved in Postinjury Smooth Muscle Cell Migration

1998 • 112 citations

Activation of Integrin αVβ3 Regulates Cell Adhesion and Migration to Bone Sialoprotein

2000 • 112 citations

Micropatterned surfaces modified with select peptides promote exclusive interactions with osteoblasts

2002 • 111 citations

Cyclic RGD peptides ameliorate ischemic acute renal failure in rats

1994 • 109 citations

Improved endothelial cell seeding with cultured cells and fibronectin-coated grafts

1985 • 109 citations

Superactivation of integrin αvβ3 by low antagonist concentrations

2001 • 108 citations

Lactide-Based Poly(ethylene glycol) Polymer Networks for Scaffolds in Tissue Engineering

1996 • 108 citations

Microdistribution of substratum-bound ligands affects cell function: hepatocyte spreading on PEO-tethered galactose

1998 • 107 citations

Integrin-Ligand Interaction

1997 • 107 citations

Interactions of corneal epithelial cells and surfaces modified with cell adhesion peptide combinations

2002 • 107 citations

Enhancement of osteogenesis on hydroxyapatite surface coated with synthetic peptide (EEEEEEEPRGDT) in vitro

2002 • 106 citations

Enhancing Hepatocyte Adhesion by Pulsed Plasma Deposition and Polyethylene Glycol Coupling

2000 • 102 citations

Photochemical surface derivatization of a peptide containing Arg–Gly–Asp (RGD)

1995 • 100 citations

Immobilized amines and basic amino acids as mimetic heparin-binding domains for cell surface proteoglycan-mediated adhesion.

1992 • 99 citations

The αvβ5 integrin functions as an endocytic receptor for vitronectin

1998 • 99 citations

Solid-Phase Synthesis of a Nonpeptide RGD Mimetic Library: New Selective αvβ3 Integrin Antagonists

2001 • 98 citations

Multifunctional poly(ethylene glycol) semi‐interpenetrating polymer networks as highly selective adhesive substrates for bioadhesive peptide grafting

1994 • 98 citations

The αvβ3 Integrin Regulates α5β1-mediated Cell Migration toward Fibronectin

1997 • 96 citations

The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.

1987 • 96 citations

RGD Peptides and Monoclonal Antibodies, Antagonists of αv-Integrin, Enter the Cells by Independent Endocytic Pathways

2001 • 94 citations

(ArgGlyAsp)n-Albumin conjugates as a model substratum for integrin-mediated cell adhesion

1989 • 93 citations

Effect of RGD coating on osteocompatibility of PLGA-polymer disks in a rat tibial wound

2001 • 92 citations

Adhesion-dependent control of matrix metalloproteinase-2 activation in human capillary endothelial cells

2000 • 92 citations

Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide

1989 • 92 citations

Biomolecular modification of p(AAm-co-EG/AA) IPNs supports osteoblast adhesion and phenotypic expression

1998 • 91 citations

Coating with genetic engineered hydrophobin promotes growth of fibroblasts on a hydrophobic solid

2002 • 91 citations

Hydrogels Containing Peptide or Aminosugar Sequences Implanted into the Rat Brain: Influence on Cellular Migration and Axonal Growth

1997 • 91 citations

A novel RGD-independent fibronectin assembly pathway initiated by α4β1 integrin binding to the alternatively spliced V region

2000 • 91 citations

Development of RGD peptides grafted onto silica surfaces: XPS characterization and human endothelial cell interactions

1999 • 91 citations

Osteoblast population migration characteristics on substrates modified with immobilized adhesive peptides

1999 • 91 citations

Electroactive Monolayer Substrates that Selectively Release Adherent Cells

2001 • 90 citations

Synthesis of poly(ethylene glycol)-tethered poly(propylene fumarate) and its modification with GRGD peptide

2000 • 89 citations

Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates

1994 • 88 citations

Chemical Modification of Surface Active Poly(ethylene oxide)−Poly(propylene oxide) Triblock Copolymers

1996 • 88 citations

The Regrowth of Axons within Tissue Defects in the CNS Is Promoted by Implanted Hydrogel Matrices That Contain BDNF and CNTF Producing Fibroblasts

2001 • 87 citations

Concept and progress in the development of RGD‐containing peptide pharmaceuticals

1995 • 86 citations

The role of membrane lipids in regulation of integrin functions

2000 • 85 citations

Fibroblast adhesion to RGDS shows novel features compared with fibronectin.

1987 • 85 citations

Surface immobilization of galactose onto aliphatic biodegradable polymers for hepatocyte culture

2002 • 84 citations

Polymer latexes for cell-resistant and cell-interactive surfaces

2000 • 84 citations

Fibronectin polymerization stimulates cell growth by RGD-dependent and-independent mechanisms

2000 • 83 citations

Cytoskeleton cross‐talk during cell motility

1999 • 83 citations

Cell-attachment activities of surface immobilized oligopeptides RGD, RGDS, RGDV, RGDT, and YIGSR toward five cell lines

1993 • 83 citations

Surfaces modified with covalently-immobilized adhesive peptides affect fibroblast population motility

1996 • 82 citations

Transmembrane signal transduction of the α_IIbβ₃ integrin

2002 • 82 citations

Biomodification of non-woven polyester fabrics by insulin and RGD for use in serum-free cultivation of tissue cells

2002 • 81 citations

In vivo modulation of host response and macrophage behavior by polymer networks grafted with fibronectin-derived biomimetic oligopeptides: the role of RGD and PHSRN domains

2001 • 81 citations

Modification of Oligo(poly(ethylene glycol) fumarate) Macromer with a GRGD Peptide for the Preparation of Functionalized Polymer Networks

2001 • 80 citations

Attachment of osteoblastic cells to hydroxyapatite crystals by a synthetic peptide (Glu7-Pro-Arg-Gly-Asp-Thr) containing two functional sequences of bone sialoprotein

1997 • 80 citations

The collagen receptor alpha 2 beta 1, from MG-63 and HT1080 cells, interacts with a cyclic RGD peptide

1992 • 79 citations

Novel osteoblast‐adhesive peptides for dental/orthopedic biomaterials

2002 • 79 citations

Synthetic peptide containing Arg-Gly-Asp inhibits bone formation and resorption in a mineralizing organ culture system of fetal rat parietal bones

1994 • 77 citations

Enhancement of cell interactions with collagen/glycosaminoglycan matrices by RGD derivatization

1997 • 76 citations

Protein-mediated macrophage adhesion and activation on biomaterials: a model for modulating cell behavior.

1999 • 75 citations

GRGDSP peptide-bound silicone membranes withstand mechanical flexing in vitro and display enhanced fibroblast adhesion

2002 • 75 citations

Synthesis of a novel polyurethane co-polymer containing covalently attached RGD peptide

1992 • 74 citations

Liquid, Phenylazide-End-Capped Copolymers of ε-Caprolactone and Trimethylene Carbonate: Preparation, Photocuring Characteristics, and Surface Layering

2002 • 74 citations

Growth of Endothelial Cells on Different Concentrations of Gly-Arg-Gly-Asp Photochemically Grafted in Polyethylene Glycol Modified Polyurethane

2001 • 73 citations

Delayed exposure to pulsatile shear stress improves retention of human saphenous vein endothelial cells on seeded ePTFE grafts

1991 • 72 citations

Corneal cell adhesion and proliferation on hydrogel sheets bound with cell-adhesive proteins

1991 • 72 citations

Synthesis and properties of malic acid-containing functional polymers

1999 • 71 citations

Hepatocyte adhesion, growth and differentiated function on RGD-containing proteins

2000 • 71 citations

Modification of glassy carbon surfaces with synthetic laminin-derived peptides for nerve cell attachment and neurite growth

1998 • 70 citations

An Assessment of Covalent Grafting of RGD Peptides to the Surface of a Compliant Poly(Carbonate-Urea)Urethane Vascular Conduit versus Conventional Biological Coatings: Its Role in Enhancing Cellular Retention

2002 • 69 citations

Characterization of a hyaluronic acid-Arg-Gly-Asp peptide cell attachment matrix

1996 • 69 citations

Printing patterns of biospecifically-adsorbed protein

2000 • 68 citations

Bone sialoprotein peptides are potent inhibitors of breast cancer cell adhesion to bone.

1996 • 68 citations

Swelling Induced Detachment of Chondrocytes Using RGD‐Modified Poly(N‐isopropylacrylamide) Hydrogel Beads

2002 • 68 citations

Synthesis of Poly(L-lactic acid-co-L-lysine) Graft Copolymers

1995 • 68 citations

N-hydroxysuccinimide carbonates and carbamates are useful reactive reagents for coupling ligands to lysines on proteins

1999 • 68 citations

The Eighth FIII Domain of Human Fibronectin Promotes Integrin α5β1 Binding via Stabilization of the Ninth FIII Domain

2001 • 68 citations

Quantitative Analysis of Adhesion-Mediated Cell Migration in Three-Dimensional Gels of RGD-Grafted Collagen

2000 • 66 citations

Peptide surface modification of poly(tetrafluoroethylene-co-hexafluoropropylene) enhances its interaction with central nervous system neurons

1998 • 66 citations

Culture of human vascular endothelial cells on an RGD-containing synthetic peptide attached to a starch-coated polystyrene surface: comparison with fibronectin-coated tissue grade polystyrene

1996 • 65 citations

Biological evaluation of RGD peptidomimetics, designed for the covalent derivatization of cell culture substrata, as potential promotors of cellular adhesion

1999 • 65 citations

Blood and tissue compatibility of modified polyester: Thrombosis, inflammation, and healing

1998 • 64 citations

Cell-binding Peptides Conjugated to Poly(ethylene glycol) Promote Neural Cell Aggregation

1994 • 62 citations

Comparison of different vascular prostheses and matrices in relation to endothelial seeding

1991 • 60 citations

Cross Talk between β₁and α_VIntegrins: β₁Affects β₃mRNA Stability

2001 • 59 citations

Template assembled synthetic proteins: Condensation of a multifunctional peptide to a topological template via chemoselective ligation

1993 • 58 citations

Murine macrophage behavior on peptide-grafted polyethyleneglycol-containing networks

1998 • 58 citations

Selective Adhesion of Endothelial Cells to Artificial Membranes with a Synthetic RGD-Lipopeptide

2001 • 58 citations

Biotech Gets a Grip on Cell Adhesion

1993 • 55 citations

Correlation between corneal epithelial cell outgrowth and monoclonal antibody binding to the cell binding domain of adsorbed fibronectin

1994 • 55 citations

The effect of flow on vascular endothelial cells grown in tissue culture on polytetrafluoroethylene grafts.

1986 • 54 citations

Molecular design of three‐dimensional artificial extracellular matrix: Photosensitive polymers containing cell adhesive peptide

1993 • 53 citations

Induced tissue integration of bone implants by coating with bone selective RGD-peptides in vitro and in vivo studies.

1999 • 53 citations

Adhesion Properties and Integrin Expression of Cultured Human Osteoclast-like Cells

1994 • 52 citations

Recognition Sites of RGD-Dependent Integrins

1997 • 51 citations

Residence time effects on monoclonal antibody binding to adsorbed fibrinogen

1995 • 51 citations

Integrin receptors and platelet adhesion to synthetic surfaces

1993 • 51 citations

Specific Binding of Glucose-derivatized Polymers to the Asialoglycoprotein Receptor of Mouse Primary Hepatocytes

2001 • 51 citations

Expression of Functional α4β1 Integrin by Human Dermal Fibroblasts

1993 • 50 citations

Non-RGD domains of osteopontin promote cell adhesion without involving αv integrins

1996 • 50 citations

Adult human endothelial cell seeding using expanded polytetrafluoroethylene vascular grafts: a comparison of four substrates.

1991 • 50 citations

Immediate cell signal by bone-related peptides in human osteoclast-like cells

1993 • 50 citations

Immobilisation on polystyrene of diazirine derivatives of mono- and disaccharides: biological activities of modified surfaces

2001 • 49 citations

Manipulation of cellular interactions with biomaterials toward a therapeutic outcome: A perspective

1994 • 48 citations

Cell-Adhesive Activity and Receptor-Binding Specificity of the Laminin-Derived YIGSR Sequence Grafted onto Staphylococcal Protein A1

1994 • 47 citations

Matrix Valency Regulates Integrin-mediated Lymphoid Adhesion via Syk Kinase

1999 • 47 citations

Use of recombinant and synthetic peptides as attachment factors for cells on microcarriers

1993 • 46 citations

Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates

1998 • 45 citations

Biomaterials to Spatially Regulate Cell Fate

2002 • 44 citations

The Tetraspanin CD9 Influences the Adhesion, Spreading, and Pericellular Fibronectin Matrix Assembly of Chinese Hamster Ovary Cells on Human Plasma Fibronectin

1999 • 43 citations

Development of a Novel Artificial Matrix with Cell Adhesion Peptides for Cell Culture and Artificial and Hybrid Organs

1989 • 43 citations

Modification of the adhesive properties of collagen by covalent grafting with RGD peptides

2000 • 43 citations

Functional Molecular Thin Films: Topological Templates for the Chemoselective Ligation of Antigenic Peptides to Self-Assembled Monolayers

1999 • 43 citations

Surface properties of a specifically modified high-grade medical polyurethane

2001 • 41 citations

Precoating expanded polytetrafluoroethylene grafts alters production of endothelial cell—derived thrombomodulators

1992 • 40 citations

New evidence and new hope concerning endothelial seeding of vascular grafts

1992 • 39 citations

Analogues of oxytocin with an oxime bridge using chemoselectively addressable building blocks

1996 • 39 citations

Fibroblast aggregation by suspension with conjugates of poly(ethylene glycol) and RGD

2000 • 39 citations

Intracerebral Implantation of Hydrogel‐Coupled Adhesion Peptides: Tissue Reaction

1995 • 39 citations

Enhanced gene delivery to human airway epithelial cells using an integrin-targeting lipoplex

2001 • 38 citations

N-Hydroxysuccinimide-activated glycine-sepharose

1993 • 38 citations

Precoating substrate and surface configuration determine adherence and spreading of seeded endothelial cells on polytetrafluoroethylene grafts

1989 • 38 citations

Cell Attachment and Motility on Materials Modified by Surface‐active RGD‐containing Peptides

1994 • 37 citations

Surface properties of RGD-peptide grafted polyurethane block copolymers: Variable take-off angle and cold-stage ESCA studies

1993 • 35 citations

Replacement of the Intervening Amino Acid Sequence of a Syk-Binding Diphosphopeptide by a Nonpeptide Spacer with Preservation of High Affinity

2002 • 35 citations

Identification and validation of a novel cell-recognition site (KNEED) on the 8th type III domain of fibronectin

2002 • 34 citations

Two‐dimensional artificial extracellular matrix: Bioadhesive peptide‐immobilized surface design

1993 • 33 citations

Synthesis and characterization of polymer-(multi)-peptide conjugates for control of specific cell aggregation

1998 • 33 citations

Surface modification of a biocompatible polymer based on polyurethane for artificial blood vessels

1992 • 32 citations

Human macrophage adhesion on fibronectin

2002 • 32 citations

Synthesis and Use of a New Bromoacetyl-Derivatized Heterotrifunctional Amino Acid for Conjugation of Cyclic RGD-Containing Peptides Derived from Human Bone Sialoprotein

1995 • 31 citations

Immobilization of a fibronectin fragment at the surface of a polyetherurethane film

1991 • 29 citations

Synthetic Integrin-binding Peptides Promote Adhesion and Proliferation of Human Periodontal Ligament Cells in vitro

1998 • 29 citations

Cyclotrehalins: Cyclooligosaccharide Receptors Featuring a Hydrophobic Cavity

2002 • 29 citations

Effects of an Arginine-Glycine-Aspartic Acid Peptide-Containing Artificial Matrix on Epithelial Migration In Vitro and Experimental Second-Degree Burn Wound Healing In Vivo

1996 • 28 citations

Hepatocyte adhesion to carbohydrate-derivatized surfaces. II. Regulation of cytoskeletal organization and cell morphology.

1991 • 28 citations

Fibroblast attachment to Arg-Gly-Asp peptide-immobilized poly(γ-methyl L-glutamate)

1994 • 27 citations

Adhesion of mammalian cells to a recombinant attachment factor, CBD/RGD, analyzed by image analysis

1995 • 27 citations

Engineering endogenous inflammatory cells as delivery vehicles

2002 • 27 citations

Design of a synthetic adhesion protein by grafting RGD tailed cyclic peptides on bovine serum albumin

1998 • 27 citations

Control of Cell Death by the Smart Polymeric Vehicle

2000 • 26 citations

Surface functionalization of amorphous silicon and silicon suboxides for biological applications

2003 • 25 citations

Quantitative determination of monosubstituted guanidines: A comparative study of different procedures

1983 • 25 citations

Constrained Cell Recognition Peptides Engineered into Streptavidin

1999 • 23 citations

Integrin α_vβ₃ is involved in stimulated migration of vascular adventitial fibroblasts by basic fibroblast growth factor but not platelet‐derived growth factor

2001 • 23 citations

Surface functionalization of materials to initiate auto-biocompatibilizationin vivo

2001 • 23 citations

Photoreactive analog of peptide FN-C/H-V from the carboxy-terminal heparin-binding domains of fibronectin supports endothelial cell adhesion and spreading on biomaterial surfaces

1996 • 23 citations

Experimental Study of Bioactive Polyurethane Sponge as an Artificial Trachea

1994 • 22 citations

Human serum albumin and fibrinogen interactions with an adsorbed RGD-containing peptide

1999 • 21 citations

Accelerated healing of cardiovascular textiles promoted by an RGD peptide.

1995 • 21 citations

Fibrous capsule formation in response to ultrahigh molecular weight polyethylene treated with peptides that influence adhesion.

1997 • 20 citations

Osteogenic Cell Attachment to Degradable Polymers

1991 • 20 citations

Reversible covalent immobilization of ligands and proteins on polyacrylamide gels

1985 • 20 citations

Molecular properties of poly(RGD) and its binding capacities to metastatic melanoma cells

1991 • 19 citations

Automated Solid-Phase Synthesis of Cyclic Peptides Bearing a Side-Chain Tail Designed for Subsequent Chemical Grafting

1996 • 18 citations

Application of liposomes for cancer metastasis

1997 • 18 citations

Platelets process adsorbed protein: a morphological study

1991 • 18 citations

Fibroblast aggregation by suspension with conjugates of poly(ethylene glycol) and RGD

1996 • 18 citations

Spacer molecules in peptide sequences: incorporation into analogues of atrial natriuretic factor

1991 • 18 citations

New RGD analogue inhibits human platelet adhesion and aggregation and eliminates platelet deposition on canine vascular grafts

1992 • 17 citations

A Three-State Mechanism of Integrin Activation and Signal Transduction for Integrin αvβ3

2002 • 17 citations

Spacer molecules in peptide sequences: Incorporation into analogues of atrial natriuretic factor

1997 • 16 citations

Development and characterization of a biocompatible OH‐modified copolymer based on polyurethane

1991 • 16 citations

Synthesis of hemocompatible materials. Part 1: Surface modification of polyurethanes based on poly(chloroalkylvinylether)s by RGD fragments

1994 • 15 citations

CONTEMPORARY BIOMATERIALS

1999 • 15 citations

Solid-phase synthesis of peptide-dendrimer con­jugates for an investigation of integrin binding

2001 • 15 citations

Chemistry olympians in the nation's capital

1999 • 14 citations

Interaction of cells with UHMWPE impregnated with the bioactive peptides RGD, RGE or Poly-L-lysine.

1997 • 14 citations

Festkörperchemie und Chirurgie

1999 • 12 citations

Untitled

2002 • 12 citations

Production and properties of a bifunctional fusion protein that mediates attachment of vero cells to cellulosic matrices

1995 • 11 citations

In vitro effects of matrix peptides on a cultured dermal-epidermal skin substitute

1990 • 11 citations

Modification of polystyrene cell culture surfaces by grafting a thin film of starch

1996 • 9 citations

Arg—Gly—Asp peptides in polyurethanes: Design, synthesis, and characterization

1994 • 8 citations

Precoating expanded polytetrafluoroethylene grafts alters production of endothelial cell[mdash ]derived thrombomodulators

1992 • 7 citations

biomaterials body shop Diverse approaches to diverse human needs

2000 • 7 citations

Preparation of cell-affinity adsorbents by immobilization of peptides to Sephadex G-10

1995 • 6 citations

The effect on bioadhesive polymers either freely in solution or covalently attached to a support on human macrophages.

1999 • 6 citations

Injection Molding of ProNectin®F Dispersed in Polystyrene for The Fabrication of Plastic Ware Activated Towards Attachment of Mammalian Cells

1993 • 6 citations

Konzept zur bioaktiven Ausrüstung

2001 • 5 citations

Improving the growth of anchorage-dependent cells upon abrupt passage to serum-free media.

1993 • 5 citations

ChemInform Abstract: Synthesis and Use of a New Bromoacetyl-Derivatized Heterotrifunctional Amino Acid (I) for Conjugation of Cyclic RGD-Containing Peptides Derived from Human Bone Sialoprotein.

1995 • 4 citations

ChemInform Abstract: Surface Modifications and Reactivity Assays of Polymer Films and Membranes by Selective Wet Chemistry

1999 • 4 citations

Template-assembled synthetic proteins

1996 • 4 citations

Modification of Fibroin Film with A Chimera Fibroin Fragment for Improvement of Cell Adhesion

1998 • 2 citations

New RGD analogue inhibits human platelet adhesion and aggregation and eliminates platelet deposition on canine vascular grafts

1992 • 2 citations

Self-Assembling Peptide Monolayers: Endothelial Cell Behavior on Functionalized Metal Substrates

1995 • 2 citations

Deleted Work

1955 • 0 citations