Constrained Cell Recognition Peptides Engineered into Streptavidin

Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion.

1987 • 653 citations

Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif

1991 • 580 citations

The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions

1992 • 472 citations

Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro.

1994 • 392 citations

Site-directed mutagenesis studies of the high-affinity streptavidin-biotin complex: contributions of tryptophan residues 79, 108, and 120.

1995 • 201 citations

Energetic Roles of Hydrogen Bonds at the Ureido Oxygen Binding Pocket in the Streptavidin−Biotin Complex

1998 • 128 citations

Bifunctional and multimeric complexes of streptavidin fused to single chain antibodies (scFv)

1995 • 100 citations

Streptavidin contains an RYD sequence which mimics the RGD receptor domain of fibronectin

1990 • 90 citations

High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site.

1993 • 90 citations

A Streptavidin–Protein a Chimera that allows one–step production of a variety of Specific Antibody Conjugates

1991 • 53 citations

A streptavidin-metallothionein chimera that allows specific labeling of biological materials with many different heavy metal ions.

1992 • 49 citations

Protein Loop Grafting to Construct a Variant of Tissue-type Plasminogen Activator That Binds Platelet Integrin αIIbβ3

1995 • 45 citations

A novel cell adhesive protein engineered by insertion of the Arg-Gly-Asp-Ser tetrapeptide

1989 • 32 citations

Highly efficient production of GFP and its derivatives in insect cells for visual in vitro applications

1996 • 32 citations

Identification of Biotinylated Molecules Using a Baculovirus-Expressed Luciferase-Streptavidin Fusion Protein

1996 • 25 citations

Cell-adhesive properties of streptavidin are mediated by the exposure of an RGD-like RYD site.

1992 • 24 citations

Structure of a Conformationally Constrained Arg-Gly-Asp Sequence Inserted into Human Lysozyme

1995 • 20 citations

Streptavidin blocks immune reactions mediated by fibronectin‐VLA‐5 recognition through an Arg‐Gly‐Asp mimicking site

1993 • 19 citations

Artificial Cell Adhesive Proteins Engineered by Grafting the Arg-Gly-Asp Cell Recognition Signal: Factors Modulating the Cell Adhesive Activity of the Grafted Signal1

1991 • 11 citations

Engineering of Artificial Cell Adhesion Proteins by Grafting the Arg-Gly-Asp Cell Adhesive Signal to a Calpastatin Segment

1992 • 5 citations

Engineered idiotypes. Immunochemical analysis of antigenized antibodies expressing a conformationally constrained Arg-Gly-Asp motif

1995 • 5 citations