The structural and mechanical complexity of cell-growth control

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Cancer Cell Cycles

1996 • 5,379 citations

The Origins of Order

1993 • 5,064 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Geometric Control of Cell Life and Death

1997 • 4,614 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

The origins of order

1993 • 2,842 citations

Role of cell shape in growth control

1978 • 2,434 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

A tension-based theory of morphogenesis and compact wiring in the central nervous system

1997 • 1,647 citations

TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION

1997 • 1,550 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Regulation of development and differentiation by the extracellular matrix

1993 • 1,216 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

1992 • 1,047 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

1997 • 633 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

Complexity in Biological Signaling Systems

1999 • 614 citations

Increasing Complexity of the Ras Signaling Pathway

1998 • 585 citations

The Architecture of Life

1998 • 545 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Cellular control lies in the balance of forces

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Fibrillar Collagen Inhibits Arterial Smooth Muscle Proliferation through Regulation of Cdk2 Inhibitors

1996 • 514 citations

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.

1995 • 503 citations

Integrin signalling and tyrosine phosphorylation: just the FAKs?

1998 • 502 citations

Genetic Control of Branching Morphogenesis

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Fibronectin controls capillary endothelial cell growth by modulating cell shape.

1990 • 498 citations

Assembly of cyclin D-dependent kinase and titration of p27 ^Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

1998 • 497 citations

Control of Cyclin D1, p27^Kip1, and Cell Cycle Progression in Human Capillary Endothelial Cells by Cell Shape and Cytoskeletal Tension

1998 • 476 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

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How does extracellular matrix control capillary morphogenesis?

1989 • 466 citations

Switching from differentiation to growth in hepatocytes: Control by extracellular matrix

1992 • 463 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1

1998 • 451 citations

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

1995 • 415 citations

Ras Links Growth Factor Signaling to the Cell Cycle Machinery via Regulation of Cyclin D1 and the Cdk Inhibitor p27^KIP1

1997 • 409 citations

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1997 • 402 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

Microscopic observations on the growth of blood capillaries in the living mammal

1939 • 372 citations

Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage

1996 • 371 citations

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

1991 • 368 citations

Mesenchyme-Dependent Morphogenesis and Epithelium-Specific Cytodifferentiation in Mouse Mammary Gland

1976 • 348 citations

Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis

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Growth factor activation of MAP kinase requires cell adhesion

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Self-organization, complexity and chaos: The new biology for medicine

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Signaling by integrin receptors

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The coming Kuhnian revolution in biology

1997 • 282 citations

Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-2

1995 • 274 citations

Basal lamina of embryonic salivary epithelia. Production by the epithelium and role in maintaining lobular morphology.

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Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression

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Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Geranylgeranylated Rho Small GTPase(s) Are Essential for the Degradation of p27 and Facilitate the Progression from G1 to S Phase in Growth-stimulated Rat FRTL-5 Cells

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Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.

1996 • 227 citations

Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion

1987 • 225 citations

A Microstructural Approach to Cytoskeletal Mechanics based on Tensegrity

1996 • 218 citations

Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis

1991 • 217 citations

A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*

1986 • 214 citations

Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression

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Role of basal lamina in neoplastic disorganization of tissue architecture.

1981 • 202 citations

Ras-stimulated Extracellular Signal-related Kinase 1 and RhoA Activities Coordinate Platelet-derived Growth Factor-induced G1 Progression through the Independent Regulation of Cyclin D1 and p27KIP1

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Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases

1997 • 192 citations

Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth.

1994 • 187 citations

Integrin-mediated Activation of MEK and Mitogen-activated Protein Kinase Is Independent of Ras

1996 • 187 citations

Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans

1999 • 182 citations

Ras Activity Late in G₁ Phase Required for p27^kip1 Downregulation, Passage through the Restriction Point, and Entry into S Phase in Growth Factor-Stimulated NIH 3T3 Fibroblasts

1997 • 169 citations

Effects of inhibition of basement membrane collagen deposition on rat mammary gland development

1980 • 169 citations

Ras Activation Is Necessary for Integrin-mediated Activation of Extracellular Signal-regulated Kinase 2 and Cytosolic Phospholipase A2 but Not for Cytoskeletal Organization

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p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry

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Integrin-mediated Signaling Events in Human Endothelial Cells

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Gene Expression During Normal and Malignant Differentiation

1986 • 157 citations

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

1992 • 156 citations

Expression of Autoactivated Stromelysin-1 in Mammary Glands of Transgenic Mice Leads to a Reactive Stroma During Early Development

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Progressive loss of shape-responsive metabolic controls in cells with increasingly transformed phenotype

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The Cat and Mouse Games That Genes, Viruses, and Cells Play

1997 • 138 citations

Anchorage-Dependent Transcription of the Cyclin A Gene

1996 • 136 citations

Overexpression of a Kinase-deficient Transforming Growth Factor-β Type II Receptor in Mouse Mammary Stroma Results in Increased Epithelial Branching

1999 • 122 citations

G1/S control of anchorage-independent growth in the fibroblast cell cycle.

1991 • 120 citations

Alternatively Spliced EDA Segment Regulates Fibronectin-dependent Cell Cycle Progression and Mitogenic Signal Transduction

1999 • 116 citations

RhoA Stimulates p27Kip Degradation through Its Regulation of Cyclin E/CDK2 Activity

1999 • 114 citations

Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line

1999 • 108 citations

Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation

1998 • 105 citations

Gene Expression During Normal and Malignant Differentiation

1985 • 101 citations

Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events

1996 • 96 citations

Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in vitro

1998 • 96 citations

Involvement of rho p21 in Cyclic Strain-Induced Tyrosine Phosphorylation of Focal Adhesion Kinase (pp125FAK), Morphological Changes and Migration of Endothelial Cells

1996 • 93 citations

Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin-dependent pathway.

1996 • 79 citations

A Correlation between Epithelial Proliferation Rates, Basement Membrane Component Localization Patterns, and Morphogenetic Potential in the Embryonic Mouse Lung

1998 • 77 citations

The Nature of Cancer: Morphogenesis and Progressive (Self)-Disorganization in Neoplastic Development and Progression

1995 • 69 citations

Ras Signals to the Cell Cycle Machinery via Multiple Pathways To Induce Anchorage-Independent Growth

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Ectopic Expression of Cyclin D1 but Not Cyclin E Induces Anchorage-Independent Cell Cycle Progression

1997 • 63 citations

Growth regulation by cell shape alteration and organization of the cytoskeleton.

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Loss of laminin‐5 in the epithelium–stroma interface: an immunohistochemical marker of malignancy in epithelial lesions of the breast

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The Stretching of Mouse Skin in Vivo: Effect on Epidermal Proliferation and Thickness

1980 • 56 citations

Newly Synthesized Rho A, Not Ras, Is Isoprenylated and Translocated to Membranes Coincident with Progression of the G1 to S Phase of Growth-stimulated Rat FRTL-5 Cells

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Loss of basement membrane components laminin and type IV collagen parallels the progression of oral epithelial neoplasia

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An anchorage-dependent signal distinct from p42/44 MAP kinase activation is required for cell cycle progression

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Effects of papaverine and calcium-free medium on salivary gland morphogenesis

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The role of cell proliferation and cellular shape change in branching morphogenesis of the embryonic mouse lung: Analysis using aphidicolin and cytochalasins

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Mechanical aspects of the mesenchymal influence on epithelial branching morphogenesis of mouse salivary gland

1987 • 37 citations

Integrin Binding to Immobilized Collagen and Fibronectin Stimulates the Proliferation of Human Thyroid Cells in Culture*

1997 • 32 citations

Effect of adhesion factors fibronectin, laminin, and type IV collagen on spreading and growth of transformed and control rat liver epithelial cells.

1987 • 29 citations

Comparison between ectoderm-conditioned medium and fibronectin in their effects on chondrogenesis by limb bud mesenchymal cells

1990 • 24 citations

Loss of Cell Adhesion to Substratum Up-Regulates p21Cip1/WAF1Expression in BALB/c 3T3 Fibroblasts

1997 • 11 citations