Activation of Integrin αVβ3 Regulates Cell Adhesion and Migration to Bone Sialoprotein

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS

1996 • 3,074 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

β3-integrin–deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival

1999 • 731 citations

Integrin signaling and cell growth control

1998 • 655 citations

The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development

1999 • 651 citations

Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.

1987 • 574 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

1993 • 537 citations

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

1995 • 508 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Inside-out integrin signalling

1992 • 439 citations

Osteomimetic properties of prostate cancer cells: A hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment

1999 • 428 citations

Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.

1996 • 365 citations

Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.

1991 • 357 citations

Fibronectin and Its Integrin Receptors in Cancer

1999 • 338 citations

Regulation of Integrin α5β1-Fibronectin Interactions by Divalent Cations

1995 • 325 citations

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

1988 • 254 citations

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen

1992 • 239 citations

Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology.

1997 • 215 citations

A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis.

1989 • 206 citations

Fibrinogen Is a Ligand for Integrin α5β1 on Endothelial Cells

1997 • 172 citations

Basic FGF and TGF-β differentially modulate integrin expression of human microvascular endothelial cells

1992 • 163 citations

Prognostic Value of Bone Sialoprotein Expression in Clinically Localized Human Prostate Cancer

1998 • 158 citations

Mechanisms and Consequences of Affinity Modulation of Integrin αVβ3 Detected with a Novel Patch-engineered Monovalent Ligand

1999 • 158 citations

Bone sialoprotein supports breast cancer cell adhesion proliferation and migration through differential usage of the αvβ3 and αvβ5 integrins

1998 • 146 citations

Role of integrin alpha(v)beta3 in vascular biology.

1998 • 141 citations

Role of Integrin αvβ3 in Vascular Biology

1998 • 136 citations

Alphav integrins mediate adhesion and migration of breast carcinoma cell lines.

1997 • 125 citations

Bone sialoprotein expression in primary human breast cancer is associated with bone metastases development

1996 • 118 citations

A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3‐kinase

1994 • 115 citations

Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells.

1991 • 115 citations

Growth Factor–dependent Activation of αvβ3 Integrin in Normal Epithelial Cells: Implications for Tumor Invasion

1998 • 110 citations

Activation of αVβ3 on Vascular Cells Controls Recognition of Prothrombin

1998 • 109 citations

Agonist-activated αvμ3 on Platelets and Lymphocytes Binds to the Matrix Protein Osteopontin

1997 • 106 citations

Purification and fragmentation of nondenatured bone sialoprotein: Evidence for a cryptic, RGD-resistant cell attachment domain

1993 • 103 citations

Signal-transduction cascades as targets for therapeutic intervention by natural products

1998 • 102 citations

The Staining of Acidic Proteins on Polyacrylamide Gels: Enhanced Sensitivity and Stability of “Stains-All” Staining in Combination with Silver Nitrate

1997 • 96 citations

A rat osteogenic cell line (UMR 106-01) synthesizes a highly sulfated form of bone sialoprotein.

1990 • 91 citations

Requirement of Integrin β3 Tyrosine 747 for β3 Tyrosine Phosphorylation and Regulation of αvβ3 Avidity

1997 • 86 citations

Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments.

1992 • 83 citations

Alternatively spliced variants: A new view of the integrin cytoplasmic domain

1997 • 77 citations

Transmembrane-truncated αvβ3 integrin retains high affinity for ligand binding: evidence for an ‘inside-out’ suppressor?

1998 • 76 citations

Expression of Bone Sialoprotein in Human Lung Cancer

1997 • 76 citations

Role of the β3 Integrin Subunit in Human Primary Melanoma Progression

1998 • 70 citations

A Mutation in the Extracellular Cysteine-Rich Repeat Region of the β3 Subunit Activates Integrins IIbβ3 and Vβ3

1999 • 69 citations

Bone sialoprotein peptides are potent inhibitors of breast cancer cell adhesion to bone.

1996 • 68 citations

Signaling mechanisms and the activation of leukocyte integrins

1997 • 64 citations

Restricted and coordinated expression of β3-integrin and bone sialoprotein during cultured osteoblast differentiation

1999 • 50 citations

A Recombinant Soluble Form of the Integrin IIbβ3 (GPIIb-IIIa) Assumes an Active, Ligand-Binding Conformation and Is Recognized by GPIIb-IIIa–Specific Monoclonal, Allo-, Auto-, and Drug-Dependent Platelet Antibodies

1998 • 47 citations

Purification, characterization, and studies on biosynthesis of a 59-kDa bone sialic acid-containing protein (BSP) from rat mandible using a monoclonal antibody. Evidence that 59-kDa BSP may be the rat counterpart of human alpha 2-HS glycoprotein and is synthesized by both hepatocytes and osteoblasts

1991 • 47 citations

Detection of bone sialoprotein in human breast cancer tissue and cell lines at both protein and messenger ribonucleic acid levels.

1996 • 41 citations

Identification of an Active Sequence within the First Immunoglobulin Domain of Intercellular Cell Adhesion Molecule-1 (ICAM-1) That Interacts with Fibrinogen

1996 • 40 citations

Differential regulation of chemoattractant-stimulated beta 2, beta 3, and beta 7 integrin activity.

1998 • 37 citations

Bone sialoprotein—a mucin in disguise?

1996 • 35 citations

Differential Regulation of Chemoattractant-Stimulated β2, β3, and β7 Integrin Activity

1998 • 33 citations

Deleted Work

1955 • 0 citations