Recognition Sites of RGD-Dependent Integrins

Adhesion receptors of the immune system

1990 • 6,585 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Arg-Gly-Asp: A versatile cell recognition signal

1986 • 1,413 citations

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

1986 • 1,078 citations

Platelet Membrane Glycoprotein IIb/IIIa: Member of a Family of Arg-Gly-Asp—Specific Adhesion Receptors

1986 • 945 citations

The three-dimensional structure of foot-and-mouth disease virus at 2.9 Å resolution

1989 • 854 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Variants of the cell recognition site of fibronectin that retain attachment-promoting activity.

1984 • 685 citations

Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion.

1987 • 653 citations

A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells

1986 • 634 citations

2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region

1996 • 621 citations

The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.

1994 • 617 citations

The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.

1985 • 594 citations

Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.

1987 • 574 citations

Adhesive recognition sequences

1991 • 571 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

Arg‐Gly‐Asp constrained within cyclic pentapoptides Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1

1991 • 543 citations

Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.

1994 • 527 citations

A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.

1985 • 517 citations

Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.

1993 • 515 citations

Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein

1992 • 500 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions

1992 • 472 citations

Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function.

1984 • 465 citations

Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations.

1991 • 447 citations

The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets.

1985 • 437 citations

Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin.

1985 • 418 citations

The Cell Attachment Site on Foot-and-Mouth Disease Virus Includes the Amino Acid Sequence RGD (Arginine-Glycine-Aspartic Acid)

1989 • 389 citations

Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri

1991 • 373 citations

Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function

1988 • 372 citations

Refined structure of the Hirudin-thrombin complex

1991 • 370 citations

Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus.

1988 • 365 citations

Structure of a major immunogenic site on foot-and-mouth disease virus

1993 • 361 citations

Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence.

1989 • 350 citations

Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library.

1993 • 344 citations

Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells

1989 • 343 citations

Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex.

1987 • 323 citations

Role of fibrinogen alpha and gamma chain sites in platelet aggregation.

1992 • 315 citations

Conformation/activity studies of rationally designed potent anti‐adhesive RGD peptides

1992 • 314 citations

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library

1994 • 308 citations

Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells.

1991 • 301 citations

Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin

1985 • 299 citations

Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.

1992 • 292 citations

Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms.

1993 • 290 citations

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin.

1990 • 282 citations

Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells

1993 • 276 citations

Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library

1992 • 275 citations

A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin.

1993 • 264 citations

RGD sequence of foot-and-mouth disease virus isessential for infecting cells via the natural receptor but can be bypassed by anantibody-dependent enhancement pathway.

1994 • 258 citations

Cell attachment properties of collagen type VI and arg-gly-asp dependent binding to its α2(VI) and α3(VI) chains

1989 • 252 citations

Multiple integrins mediate cell attachment to cytotactin/tenascin.

1993 • 248 citations

Identification of a bone sialoprotein receptor in osteosarcoma cells.

1988 • 248 citations

A Biochemical Characterization of the Binding of Osteopontin to Integrins αvβ1 and αvβ5

1995 • 245 citations

The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues

1991 • 244 citations

Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3.

1996 • 232 citations

Tenascin mediates cell attachment through an RGD-dependent receptor.

1989 • 231 citations

Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion.

1985 • 220 citations

The Human Integrin α8β1 Functions as a Receptor for Tenascin, Fibronectin, and Vitronectin

1995 • 216 citations

Interaction of type IV collagen with the isolated integrins α1β1 and α2β1

1993 • 215 citations

Effects of Modifications of the RGD Sequence and Its Context on Recognition by the Fibronectin Receptor

1989 • 213 citations

A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen

1989 • 213 citations

Integrin and Arg-Gly-Asp Dependence of Cell Adhesion to the Native and Unfolded Triple Helix of Collagen Type VI

1993 • 212 citations

Molecular and biological characteristics of echovirus 22, a representative of a new picornavirus group

1994 • 209 citations

Crystal structure of the tenth type III cell adhesion module of human fibronectin

1994 • 207 citations

A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis.

1989 • 206 citations

Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins.

1994 • 198 citations

Structure of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibody: direct involvement of the Arg-Gly-Asp motif in the interaction.

1995 • 194 citations

Low molecular weight, non-peptide fibrinogen receptor antagonists

1992 • 190 citations

Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro

1991 • 189 citations

Cell-type Specific Recognition of RGD- and Non-RGD-containing Cell Binding Domains in Fibrillin-1

1996 • 184 citations

Discoidin I is implicated in cell-substratum attachment and ordered cell migration of dictyostelium discoideum and resembles fibronectin

1984 • 184 citations

The effect of Arg-Gry-Asp-containing peptides on tibrinogen and von Willebrand factor binding to platelets.

1985 • 181 citations

Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan.

1992 • 180 citations

Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis

1991 • 180 citations

RGD-directed attachment of isolated rat osteoclasts to osteopontin, bone sialoprotein, and fibronectin

1992 • 177 citations

Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human immunodeficiency virus type 1 transactivation protein, tat.

1990 • 177 citations

Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila αPS2βPS integrins

1994 • 170 citations

Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence

1996 • 170 citations

The interaction of fibronectin fragments with fibroblastic cells.

1985 • 168 citations

Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to platelets

1987 • 165 citations

Cell adhesion and integrin binding to recombinant human fibrillin-1

1996 • 163 citations

Endothelial cells adhere to the rgd domain and the fibrinogen-like terminal knob of tenascin

1993 • 161 citations

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

1989 • 158 citations

RGD-dependent entry of coxsackievirus A9 into host cells and its bypass after cleavage of VP1 protein by intestinal proteases

1991 • 157 citations

Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assembly.

1991 • 156 citations

Identification of the Arg‐Gly‐Asp sequence in laminin A chain as a latent cell‐binding site being exposed in fragment P1

1990 • 150 citations

The L1 adhesion molecule is a cellular ligand for VLA-5.

1995 • 149 citations

Amino Acid Sequences in Fibrinogen Mediating Its Interaction with Its Platelet Receptor, GPIIbIIIa

1989 • 145 citations

Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin .alpha.IIb.beta.3 antagonists

1994 • 141 citations

Structure of the RGD Protein Decorsin: Conserved Motif and Distinct Function in Leech Proteins That Affect Blood Clotting

1994 • 140 citations

The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen.

1990 • 137 citations

Conformational Transitions in the Cell Binding Domain of Fibronectin

1995 • 136 citations

Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites.

1990 • 131 citations

Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa.

1993 • 130 citations

Reversible conformational changes induced in glycoprotein IIb-IIIa by a potent and selective peptidomimetic inhibitor

1992 • 129 citations

Entactin stimulates neutrophil adhesion and chemotaxis through interactions between its Arg-Gly-Asp (RGD) domain and the leukocyte response integrin.

1992 • 129 citations

Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesion

1993 • 125 citations

Peptide Ligands for Integrin .alpha.v.beta.3 Selected from Random Phage Display Libraries

1995 • 123 citations

Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.

1994 • 122 citations

An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments]

1989 • 119 citations

Fibronectin-plasma membrane interaction in the adhesion of hemopoietic cells.

1986 • 115 citations

Ca2+Suppresses Cell Adhesion to Osteopontin by Attenuating Binding Affinity for Integrin αvβ3

1995 • 114 citations

Von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism.

1989 • 112 citations

Disulfides modulate RGD-inhibitable cell adhesive activity of thrombospondin.

1992 • 110 citations

Cyclic RGD peptides ameliorate ischemic acute renal failure in rats

1994 • 109 citations

Amino acid sequence specificities of an adhesive recognition signal

1985 • 106 citations

Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) recognizes multiple sites in fibronectin.

1991 • 105 citations

Site‐directed mutagenesis of the arginine‐glycine‐aspartic acid sequence in osteopontin destroys cell adhesion and migration functions

1995 • 105 citations

The basement membrane glycoprotein entactin promotes cell attachment and binds calcium ions.

1990 • 104 citations

Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin.

1995 • 104 citations

Comparison of Disintegrins with Limited Variation in the RGD Loop in Their Binding to Purified Integrins αIIbβ3, αVβ3 and α5β1 and in Cell Adhesion Inhibition

1994 • 104 citations

An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion.

1991 • 103 citations

Receptor for the cell binding site of discoidin I

1985 • 96 citations

Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin.

1994 • 96 citations

Binding of Purified Collagen Receptors (α1β1, α2β1) and RGD‐Dependent Integrins to Laminins and Laminin Fragments

1994 • 94 citations

Pathogenetic role of Arg-Gly-Asp-recognizing integrins in acute renal failure. off.

1993 • 92 citations

Presence of a vertebrate fibrinogen-like sequence in an echinoderm.

1990 • 91 citations

Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides

1992 • 90 citations

High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site.

1993 • 90 citations

Generation and characterization of peptide-specific antibodies that inhibit von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly1745-Asp1746.

1988 • 90 citations

Receptor binding site-deleted foot-and-mouth disease (FMD) virus protects cattle from FMD

1995 • 89 citations

The Ser-Arg-Tyr-Asp region of the major surface glycoprotein of Leishmania mimics the Arg-Gly-Asp-Ser cell attachment region of fibronectin.

1992 • 89 citations

Concept and progress in the development of RGD‐containing peptide pharmaceuticals

1995 • 86 citations

Drosophila PS2 integrin mediates RGD-dependent cell-matrix interactions

1992 • 85 citations

Structural studies of potent constrained RGD peptides

1992 • 79 citations

The collagen receptor alpha 2 beta 1, from MG-63 and HT1080 cells, interacts with a cyclic RGD peptide

1992 • 79 citations

Identification of the disulfide bond pattern in albolabrin, an RGD-containing peptide from the venon of trimeresurus albolabris: Significance for the express of platelet aggregation inhibitory activity

1991 • 79 citations

Release of Biological Activities from Quiescent Fibronectin by a Conformational Change and Limited Proteolysis by Matrix Metalloproteinases

1995 • 76 citations

Multiple cell surface receptors for the short arms of laminin: alpha 1 beta 1 integrin and RGD-dependent proteins mediate cell attachment only to domains III in murine tumor laminin.

1991 • 76 citations

Development of GPIIb/IIIa antagonists as antithrombotic drugs

1992 • 74 citations

Antiplatelet Agents in the Prevention and Therapy of Thrombosis

1992 • 73 citations

Role of the glycoprotein Ib-binding A1 repeat and the RGD sequence in platelet adhesion to human recombinant von Willebrand factor

1995 • 73 citations

Binding interactions of kistrin with platelet glycoprotein IIb‐IIIa: Analysis by site‐directed mutagenesis

1993 • 71 citations

Recombinant Domain III of Perlecan Promotes Cell Attachment through Its RGDS Sequence

1995 • 68 citations

Non-Peptide Fibrinogen Receptor Antagonists. 7. Design and Synthesis of a Potent, Orally Active Fibrinogen Receptor Antagonist

1995 • 64 citations

Candida albicans expresses a fibronectin receptor antigenically related to 5 1 integrin

1994 • 58 citations

αvβ1 is a receptor for vitronectin and fibrinogen, and acts with α5β1 to mediate spreading on fibronectin

1995 • 55 citations

Antithrombotic effects and bleeding time prolongation with synthetic platelet GPIIb/IIIa inhibitors in animal models of platelet-mediated thrombosis.

1994 • 54 citations

Structural analysis of integrin recognition and the inhibition of integrin-mediated cell functions by novel nonpeptidic surrogates of the Arg-Gly-Asp sequence

1993 • 52 citations

Structural and functional aspects of RGD-containing protein antagonists of glycoprotein IIb-IIIa

1993 • 50 citations

Structural and functional analyses of the Arg-Gly-Asp sequence introduced into human lysozyme

1993 • 48 citations

Manipulation of cellular interactions with biomaterials toward a therapeutic outcome: A perspective

1994 • 48 citations

Protein Loop Grafting to Construct a Variant of Tissue-type Plasminogen Activator That Binds Platelet Integrin αIIbβ3

1995 • 45 citations

Antithrombotic Effects and Bleeding Time Prolongation with Synthetic Platelet GPIIb/llla Inhibitors in Animal Models of Platelet-Mediated Thrombosis

1994 • 44 citations

Crystal Structure of the OPG2 Fab

1995 • 43 citations

Blockade of osteoclast‐mediated bone resorption through occupancy of the integrin receptor: A potential approach to the therapy of osteoporosis

1994 • 42 citations

Integrin-Binding and Cell-Adhesion Studies of Fibulins Reveal a Particular Affinity for αIIbβ3

1995 • 40 citations

A novel approach to the design of potent bioactive peptides by incorporation of proline brackets: antiplatelet effects of Arg‐Gly‐Asp peptides

1995 • 38 citations

Diversity of primary structures of the carboxy-terminal regions of mammalian fibrinogen A alpha-chains. Characterization of the partial nucleotide and deduced amino acid sequences in five mammalian species; rhesus monkey, pig, dog, mouse and Syrian hamster.

1993 • 36 citations

Strong inhibition of fibrinogen binding to platelet receptor α_IIbβ₃ by RGD sequences installed into a presentation scaffold

1993 • 34 citations

Isolation of Leukocyte Response Integrin: A Novel RGD-Binding Protein Involved in Regulation of Phagocytic Function

1993 • 33 citations

DNA Polymerase III: Running Rings around the Fork

1996 • 32 citations

Recognition of cryptic sites in human and mouse laminins by rat osteoclasts is mediated by β3 and β1 integrins

1994 • 31 citations

Arg-Gly-Asp (RGD) peptides alter hepatic killing of Candida albicans in the isolated perfused mouse liver model

1992 • 28 citations

Thrombin adhesive properties: induction by plasmin and heparan sulfate.

1993 • 28 citations

Diversity of Primary Structures of the Carboxy-terminal Regions of Mammalian Fibrinogen Aα-Chains

1993 • 27 citations

Conformational Changes in Adhesive Proteins Modulate Their Adhesive Function

1995 • 26 citations

Structure of the fibrinogen binding sequence: arginylglycylaspartic acid (RGD)

1990 • 26 citations

The attachment of nematocytes from the primitive invertebrate Hydra to fibronectin is specific and RDG-dependent

1992 • 25 citations

Cell-adhesive properties of streptavidin are mediated by the exposure of an RGD-like RYD site.

1992 • 24 citations

Structural and functional analysis of the globular domain IVa of the laminin α1 chain and its impact on an adjacent RGD site

1996 • 22 citations

Cell adhesive activity of two animal lectins through different recognition mechanisms

1991 • 16 citations

Anti‐(Arg‐Gly‐Asp‐Ser) antibody and its interaction with fibronectin, fibrinogen and platelets

1988 • 15 citations

Substance P responsiveness of smooth muscle cells is regulated by the integrin ligand, thrombospondin.

1996 • 13 citations

Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets

1988 • 9 citations