The P-glycoprotein multidrug transporter

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis [see comments]

1992 • 507 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1986 • 410 citations

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

1991 • 407 citations

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.

1990 • 396 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

MDR1 Gene Expression and Treatment Outcome in Acute Myeloid Leukemia

1991 • 372 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

Induction of Multidrug Resistance in Human Cells by Transient Exposure to Different Chemotherapeutic Drugs

1993 • 366 citations

Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors.

1989 • 347 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 347 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

1992 • 335 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.

1992 • 322 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 290 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.

1993 • 284 citations

Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance

1988 • 278 citations

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

1990 • 271 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Use of fluorescent dyes as molecular probes for the study of multidrug resistance

1988 • 249 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 231 citations

The direct activation of human multidrug resistance gene (MDR1) by anticancer agents

1989 • 223 citations

Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents

1989 • 222 citations

Expression of the multidrug resistance-associated P-glycoprotein (P- 170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications [see comments]

1993 • 213 citations

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.

1991 • 212 citations

Expression of mdr1 and mdr3 Multidrug-resistance Genes in Human Acute and Chronic Leukemias and Association With Stimulation of Drug Accumulation by Cyclosporine

1990 • 210 citations

Multidrug resistance (mdr) genes in human cancer

1991 • 209 citations

P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy

1993 • 207 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Systemic Toxic Effects Associated With High-Dose Verapamil Infusion and Chemotherapy Administration

1991 • 185 citations

The role of the MDR1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo

1992 • 183 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1987 • 179 citations

Coinduction of MDR-1 Multidrug-Resistance and Cytochrome P-450 Genes in Rat Liver by Xenobiotics

1988 • 174 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 172 citations

Reconstitution of Drug Transport by Purified P-glycoprotein

1995 • 172 citations

Expression of the multidrug resistance-associated P-glycoprotein (P- 170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications [see comments]

1993 • 171 citations

Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells

1993 • 164 citations

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation.

1989 • 162 citations

Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.

1990 • 155 citations

Doxorubicin-loaded nanospheres bypass tumor cell multidrug resistance

1992 • 154 citations

Peptide transport by the multidrug resistance pump.

1992 • 152 citations

Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells

1993 • 142 citations

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.

1992 • 140 citations

SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity.

1993 • 140 citations

Cortisol is transported by the multidrug resistance gene product P-glycoprotein

1993 • 138 citations

P-Glycoprotein expression in treated and untreated human breast cancer

1989 • 133 citations

Phosphorylation of the multidrug resistance associated glycoprotein

1987 • 131 citations

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein

1993 • 131 citations

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.

1990 • 129 citations

Expression of the multidrug resistance gene product (P‐glycoprotein) in myelodysplasia is associated with a stem cell phenotype

1991 • 126 citations

Regulation of 2‐acetylaminofluorene‐and 3‐methylcholanthrene‐mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver

1991 • 125 citations

Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists.

1993 • 125 citations

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals

1988 • 125 citations

A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.

1993 • 124 citations

Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists.

1992 • 118 citations

Expression of multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) genes in acute myeloid leukemia.

1995 • 115 citations

Multidrug resistance in lymphomas.

1994 • 115 citations

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.

1992 • 114 citations

Correlation of MDR1 Gene Expression With Chemotherapy in Neuroblastoma

1989 • 112 citations

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

1992 • 111 citations

A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase

1993 • 107 citations

Modulation of doxorubicin resistance in multidrug‐resistant cells by liposomes

1993 • 106 citations

Overexpression of the MDR1 Gene and P-Glycoprotein in Human Hepatocellular Carcinoma

1992 • 104 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates

1993 • 101 citations

A new functional role for P-glycoprotein: efflux pump for benzo(alpha)pyrene in human breast cancer MCF-7 cells.

1992 • 101 citations

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.

1985 • 100 citations

On the characteristics of actinomycin D resistance in L5178Y cells.

1970 • 100 citations

NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter.

1994 • 99 citations

Differential modulation of P-glycoprotein transport by protein kinase inhibition

1993 • 93 citations

Expression of the multidrug transporter, P‐glycoprotein, in chronic myelogenous leukaemia cells in blast crisis

1990 • 92 citations

P-glycoprotein and pharmacokinetics.

1995 • 92 citations

Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection.

1994 • 87 citations

Rational design and pre-clinical pharmacology of drugs for reversing multidrug resistance

1992 • 86 citations

Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression or gene amplification.

1989 • 86 citations

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

1992 • 85 citations

Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas.

1990 • 85 citations

Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells.

1993 • 84 citations

Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes

1993 • 84 citations

Expression of the MDR1 Gene in Human Gastric and Colorectal Carcinomas

1990 • 81 citations

Heat‐shock responsive elements in the induction of the multidrug resistance gene (MDR1)

1992 • 81 citations

Regulation of the multidrug resistance gene in regenerating rat liver.

1990 • 77 citations

Progesterone regulates the murine multidrug resistance mdr1b gene.

1993 • 73 citations

Expression of multidrug resistance gene and localization of P-glycoprotein in human primary ovarian cancer.

1994 • 73 citations

Expression of P-glycoprotein and glutathione-S-transferase in recurrent lymphomas: the possible role of Epstein-Barr virus, immunophenotypes, and other predisposing factors.

1993 • 70 citations

Evidence for transcriptional control of human mdr1 gene expression by verapamil in multidrug-resistant leukemic cells.

1995 • 69 citations

Continued expression of vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase.

1982 • 68 citations

Low External pH and Osmotic Shock Increase the Expression of Human MDR Protein

1994 • 66 citations

Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells

1997 • 63 citations

Expression of P-glycoprotein in de novo acute myelogenous leukemia at initial diagnosis: results of molecular and functional assays, and correlation with treatment outcome.

1994 • 63 citations

Restoration of Taxol Sensitivity of Multidrug-Resistant Cells by the Cyclosporine SDZ PSC 833 and the Cyclopeptolide SDZ 280-446

1993 • 63 citations

Regulation of P-glycoprotein gene expression in hepatocyte cultures and liver cell lines by a trans-acting transcriptional repressor

1992 • 62 citations

Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells

1995 • 61 citations

Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgp1 reveals that the AP-1 site is essential for full promoter activity.

1991 • 60 citations

Resistance to cytostatic drugs at the cellular level

1992 • 59 citations

Multi-drug resistance (MDR) activity in acute leukemia determined by rhodamine 123 efflux assay.

1995 • 59 citations

Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture

1992 • 58 citations

Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells.

1994 • 55 citations

Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells.

1994 • 53 citations

Multidrug Resistance in the Laboratory and Clinic

1994 • 52 citations

Constitutive expression of multidrug resistance in human colorectal tumours and cell lines

1993 • 52 citations

The antiprogestatin drug RU 486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P‐glycoprotein function

1994 • 50 citations

P-Glycoprotein expression in human, mouse, hamster and rat hepatocytes in primary culture

1993 • 48 citations

Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Monoclonal Antibodies, Immunotoxins or Antisense Oligodeoxynucleotides in Kidney Carcinoma and Normal Kidney Cells

1993 • 47 citations

The effect of MDR-1 gene expression on outcome in acute myeloblastic leukaemia

1994 • 47 citations

Structural and Functional Analyses of the Promoter of the Murine Multidrug Resistance Genemdr3/mdrlaReveal a Negative Element Containing the AP-1 Binding Site

1991 • 44 citations

Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells

1994 • 43 citations

Detection of P glycoprotein activity on normal and leukemic CD34+ cells

1993 • 39 citations

Low incidence of MDR1 expression in acute promyelocytic leukaemia

1995 • 36 citations

Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter

1995 • 32 citations

Estradiol induction of rhodamine 123 efflux and the multidrug resistance pump in rat pituitary tumor cells.

1993 • 29 citations

Expression and function of multidrug resistance P-glycoprotein in a cultured natural killer cell-rich population revealed by MRK16 monoclonal antibody and AHC-52

1994 • 28 citations

Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1.

1990 • 27 citations

Multiple drug resistance gene expression in human renal cell cancer is associated with the histologic subtype

1992 • 26 citations

Constitutive expression of functional P‐glycoprotein in rat hepatoma cells

1994 • 26 citations

Phenotype of syngeneic tumor-specific cytotoxic T-lymphocytes and requirements for their in vitro generation from tumor-bearing host and immune spleens.

1988 • 26 citations

Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells

1993 • 26 citations

Selective drug transport and P-glycoprotein activity in an in vitro blood-brain barrier model

1995 • 15 citations

GST‐7T and P‐170 co‐expression in multiple myeloma

1995 • 12 citations

Suppression of multi‐drug resistance gene expression in the mouse liver by 1,4‐bis[2,(3,5‐dichloropyridyloxy)]benzene

1994 • 11 citations

Multidrug Resistance in B-Cell Chronic Lymphocytic Leukemia

1995 • 10 citations