Regulation of P-glycoprotein gene expression in hepatocyte cultures and liver cell lines by a trans-acting transcriptional repressor

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Inhibitors of Ribosome Functions

1971 • 672 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.

1986 • 548 citations

Extreme instability of myc mRNA in normal and transformed human cells.

1984 • 522 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

The rat serum albumin gene: analysis of cloned sequences.

1979 • 400 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Specific stimulation of actin gene transcription by epidermal growth factor and cycloheximide.

1984 • 215 citations

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

1987 • 206 citations

Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein.

1983 • 201 citations

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

1987 • 196 citations

Temporal and tissue-specific expression of mouse ets genes.

1987 • 191 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Coinduction of MDR-1 Multidrug-Resistance and Cytochrome P-450 Genes in Rat Liver by Xenobiotics

1988 • 174 citations

Expression of liver phenotypes in cultured mouse hepatoma cells: Synthesis and secretion of serum albumin

1973 • 171 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia

1989 • 135 citations

Effect of Protein Synthesis Inhibitors on Growth Factor Activation of c-fos, c-myc, and Actin Gene Transcription

1986 • 132 citations

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.

1990 • 129 citations

Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells.

1984 • 128 citations

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

1990 • 126 citations

Regulation of 2‐acetylaminofluorene‐and 3‐methylcholanthrene‐mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver

1991 • 125 citations

Superinduction of cytochrome P1-450 gene transcription by inhibition of protein synthesis in wild type and variant mouse hepatoma cells.

1985 • 107 citations

Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family

1991 • 104 citations

Elsie 4: Quantitative computer analysis of sets of two-dimensional gel electrophoretograms

1988 • 85 citations

Regulation of the multidrug resistance gene in regenerating rat liver.

1990 • 77 citations

Overexpression and Amplification of Five Genes in a Multidrug-Resistant Chinese Hamster Ovary Cell Line

1986 • 68 citations

Evidence that the Functional β-Actin Gene Is Single Copy in Most Mice and Is Associated with 5′ Sequences Capable of Conferring Serum- and Cycloheximide-Dependent Regulation

1988 • 66 citations

Structural and functional analysis of the mouse mdr1b gene promoter

1991 • 59 citations

Apolipoprotein C-II mRNA levels in primate liver. Induction by estrogen in the human hepatocarcinoma cell line, HepG2.

1985 • 56 citations

Inhibitors of protein synthesis in eukaryotes: tools in cell research.

1973 • 50 citations

The human multidrug resistance gene: sequences upstream and downstream of the initiation site influence transcription.

1990 • 48 citations

Noncoordinate regulation of the mRNAs encoding cytochromes P-450BNF/MC-B and P-450ISF/BNF-G

1986 • 45 citations

Notes: Cell-Specific Activity of cis-Acting Regulatory Elements in the Promoter of the Mouse Multidrug Resistance Gene mdr1

1990 • 45 citations

Cloning and Characterization of a Second Member of the Mouse mdr Gene Family

1988 • 45 citations

Structural and Functional Analyses of the Promoter of the Murine Multidrug Resistance Genemdr3/mdrlaReveal a Negative Element Containing the AP-1 Binding Site

1991 • 44 citations

Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats.

1987 • 44 citations

The induction of cytochrome P-450 by isosafrole and related methylenedioxyphenyl compounds

1985 • 36 citations

Regulation of mRNA abundance in activated T lymphocytes: identification of mRNA species affected by the inhibition of protein synthesis.

1990 • 32 citations

Stabilization of Tubulin mRNA by Inhibition of Protein Synthesis in Sea Urchin Embryos

1988 • 27 citations

Physical Mapping, Amplification, and Overexpression of the Mouse mdr Gene Family in Multidrug-Resistant Cells

1990 • 26 citations

mdr‐1 GENE AMPLIFICATION IN ACUTE LYMPHOBLASTIC LEUKAEMIA PRIOR TO ANTILEUKAEMIC TREATMENT

1991 • 24 citations

Structural Analysis of the Mouse mdr1a (P-Glycoprotein) Promoter Reveals the Basis for Differential Transcript Heterogeneity in Multidrug-Resistant J774.2 Cells

1990 • 19 citations

Induction by cycloheximide of the glycoprotein hormone alpha-subunit gene in human tumor cell lines and identification of a possible negative regulatory factor.

1990 • 15 citations

Role of the 4-5S binding protein in the induction of arylhydrocarbon hydroxylase in the rat

1988 • 15 citations