Multidrug resistance (mdr) genes in human cancer

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Mechanism of multidrug resistance

1988 • 630 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.

1990 • 396 citations

Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors.

1989 • 347 citations

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

1986 • 321 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

P-glycoprotein in human sarcoma: evidence for multidrug resistance.

1987 • 261 citations

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein.

1989 • 242 citations

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

1989 • 233 citations

Mechanism of cross-resistance between vincristine and daunorubicin in Ehrlich ascites tumor cells.

1978 • 231 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

The direct activation of human multidrug resistance gene (MDR1) by anticancer agents

1989 • 223 citations

DETECTION OF A MULTIDRUG RESISTANT PHENOTYPE IN ACUTE NON-LYMPHOBLASTIC LEUKAEMIA

1987 • 223 citations

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

1989 • 217 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Expression of mdr1 and mdr3 Multidrug-resistance Genes in Human Acute and Chronic Leukemias and Association With Stimulation of Drug Accumulation by Cyclosporine

1990 • 210 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

Prediction of Doxorubicin Resistance In Vitro in Myeloma, Lymphoma, and Breast Cancer by P-Glycoprotein Staining

1989 • 202 citations

CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered β-tubulin

1980 • 201 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

1981 • 191 citations

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues.

1984 • 182 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1987 • 179 citations

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

1988 • 176 citations

P-glycoproteins in pathology: The multidrug resistance gene family in humans

1990 • 173 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

Multidrug Resistance

1989 • 166 citations

P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD

1989 • 162 citations

Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin.

1972 • 157 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

Expression of a Human Multidrug Resistance cDNA (MDR1) in the Bone Marrow of Transgenic Mice: Resistance to Daunomycin-Induced Leukopenia

1989 • 151 citations

Anthracycline resistance in P388 murine leukemia and its circumvention by calcium antagonists.

1985 • 149 citations

The effect of verapamil on the pharmacokinetics of adriamycin

1986 • 146 citations

Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.

1989 • 138 citations

Overexpression of the MDRL gene in blast cells from patients with acute myelocytic leukemia is associated with decreased anthracycline accumulation that can be restored by cyclosporin‐A

1990 • 136 citations

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia

1989 • 135 citations

P-Glycoprotein expression in treated and untreated human breast cancer

1989 • 133 citations

Expression of the multidrug resistance, MDR1, gene in neuroblastomas.

1990 • 132 citations

Modification of cytotoxic drug resistance by non-immuno-suppressive cyclosporins

1988 • 125 citations

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial.

1988 • 124 citations

Measurement of Multidrug-Resistance Messenger RNA in Urogenital Cancers; Elevated Expression in Renal Cell Carcinoma is Associated with Intrinsic Drug Resistance

1988 • 124 citations

Expression of a human multidrug resistance gene in ovarian carcinomas.

1989 • 115 citations

Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo.

1972 • 115 citations

MDR1 RNA Levels in Human Renal Cell Carcinomas: Correlation With Grade and Prediction of Reversal of Doxorubicin Resistance by Quinidine in Tumor Explants

1989 • 114 citations

Correlation of MDR1 Gene Expression With Chemotherapy in Neuroblastoma

1989 • 112 citations

Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine

1988 • 110 citations

Transport of melphalan by sensitive and resistant L1210 cells.

1980 • 109 citations

Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate

1980 • 106 citations

Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.

1989 • 104 citations

On the characteristics of actinomycin D resistance in L5178Y cells.

1970 • 100 citations

Markedly altered membrane transport and intracellular binding of vincristine in multidrug‐resistant Chinese hamster cells selected for resistance to vinca alkaloids

1986 • 94 citations

Reversal of drug‐resistance by cyclosporin‐A in a patient with acute myelocytic leukaemia

1990 • 89 citations

Decreased retention of actinomycin D as the basis for cross-resistance in anthracycline-resistant sublines of P388 leukemia.

1977 • 87 citations

Expression of mdr1 and gst-π in human breast tumours: comparison to in vitro chemosensitivity

1990 • 86 citations

Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

1989 • 86 citations

Reversal of multidrug resistance by lipophilic drugs.

1990 • 73 citations

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.

1987 • 72 citations

A pilot study of quinidine and epirubicin in the treatment of advanced breast cancer

1990 • 66 citations

Expression of the mdr3 gene in prolymphocytic leukemia: Association with cyclosporin‐a‐induced increase in drug accumulation

1990 • 63 citations

Effect of cyclosporin A on daunorubicin accumulation in multidrug-resistant P388 leukemia cells measured by real-time flow cytometry

1989 • 60 citations

Pharmacokinetics of vincristine in cancer patients treated with nifedipine

1989 • 54 citations

Structure and Expression of the Human MDR (P-Glycoprotein) Gene Family

1989 • 54 citations

Circumvention of adriamycin resistance by dipyridamole analogues: A structure‐activity relationship study

1989 • 52 citations

Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro.

1985 • 51 citations

Is the mdr 1 gene relevant in chronic lymphocytic leukemia

1990 • 45 citations

Cloning and Characterization of a Second Member of the Mouse mdr Gene Family

1988 • 45 citations

Flow cytometric monitoring of cellular anthracycline accumulation in murine leukemic cells.

1986 • 45 citations

Expression of a Multidrug Resistance Gene in Blast Crisis of Chronic Myelogenous Leukemia

1989 • 44 citations

Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer a phase I/II study

1990 • 43 citations

Identification of Members of the P-Glycoprotein Multigene Family

1989 • 41 citations

Repair of DNA interstrand crosslinks after busulphan

1982 • 37 citations

Effects of verapamil on the pharmacokinetics of daunomycin in the rat

1987 • 36 citations

Is the mdr 1 gene relevant in chronic lymphocytic leukemia?

1990 • 29 citations

Effects of Verapamil on Chronic Doxorubicin-Induced Cardiotoxicity in Dogs

1990 • 13 citations