Over‐expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

1992 • 446 citations

Unusual expression and localization of heat‐shock proteins in human tumor cells

1992 • 439 citations

Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.

1992 • 376 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Human HSP70 promoter contains at least two distinct regulatory domains.

1986 • 326 citations

A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.

1991 • 326 citations

Expression of human HSP70 during the synthetic phase of the cell cycle.

1986 • 316 citations

Sequence and organization of genes encoding the human 27 kDa heat shock protein

1986 • 299 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.

1987 • 237 citations

Transcription of the human hsp70 gene is induced by serum stimulation.

1985 • 235 citations

Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection.

1993 • 223 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2.

1993 • 149 citations

Simian virus 40 and polyoma virus induce synthesis of heat shock proteins in permissive cells.

1983 • 148 citations

Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells.

1988 • 133 citations

Enhanced constitutive expression of the 27‐kDa heat shock proteins in heat‐resistant variants from chinese hamster cells

1988 • 128 citations

Molecular mechanisms in tumor-cell killing by activated macrophages

1983 • 127 citations

Mediation of mouse natural cytotoxic activity by tumour necrosis factor

1986 • 117 citations

Emerging Role of Heat Shock Proteins in Biology and Medicine

1992 • 107 citations

Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells.

1988 • 72 citations

Medium tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with 73-kilodalton heat shock protein

1987 • 62 citations

Tumor necrosis factor: The molecules and their emerging role in medicine

1992 • 43 citations

Use of polymerase chain reaction to detect the expression of the Mr 70,000 heat shock genes in control or heat shock leukemic cells as correlated to their heat response.

1990 • 34 citations

The gene for the rat heat-shock cognate, hsc70, can suppress oncogene-mediated transformation.

1992 • 34 citations

Heat shock inhibits the cytotoxic action of TNF-alpha in tumor cells but does not alter its noncytotoxic actions in endothelial and adrenal cells.

1991 • 18 citations

Tumor growth in vivo selects for resistance to tumor necrosis factor.

1989 • 15 citations

In vitro selection of a cell line for resistance to lysis by tumor necrosis factor-alpha selects for reduced tumorigenicity.

1991 • 4 citations