Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Protein folding in the cell

1992 • 4,138 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

2000 • 2,195 citations

Protein misfolding, evolution and disease

1999 • 1,948 citations

The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex

1997 • 1,250 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

Structure of TPR Domain–Peptide Complexes

2000 • 1,159 citations

Folding of Newly Translated Proteins In Vivo: The Role of Molecular Chaperones

2001 • 1,157 citations

Macromolecular crowding: an important but neglected aspect of the intracellular environment

2001 • 1,097 citations

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

2000 • 971 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Hsp90

2001 • 819 citations

Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries

1997 • 797 citations

The groES and groEL heat shock gene products of Escherichia coli are essential for bacterial growth at all temperatures

1989 • 693 citations

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

1994 • 651 citations

Implications of macromolecular crowding for protein assembly

2000 • 634 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

STRUCTURE AND FUNCTION IN GroEL-MEDIATED PROTEIN FOLDING

1998 • 576 citations

Genetic Suppression of Polyglutamine Toxicity in Drosophila

2000 • 562 citations

Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin

1998 • 548 citations

The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE.

1994 • 520 citations

Effects of macromolecular crowding on protein folding and aggregation

1999 • 506 citations

Identification of in vivo substrates of the chaperonin GroEL

1999 • 499 citations

Molecular chaperones: proteins essential for the biogenesis of some macromolecular structures

1989 • 491 citations

Trigger factor and DnaK cooperate in folding of newly synthesized proteins

1999 • 491 citations

Crystal Structure of the Nucleotide Exchange Factor GrpE Bound to the ATPase Domain of the Molecular Chaperone DnaK

1997 • 489 citations

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

2001 • 489 citations

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

2000 • 478 citations

The complete sequence of the mucosal pathogen Ureaplasma urealyticum

2000 • 432 citations

Structure of a Bag/Hsc70 Complex: Convergent Functional Evolution of Hsp70 Nucleotide Exchange Factors

2001 • 427 citations

Getting Newly Synthesized Proteins into Shape

2000 • 426 citations

Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT

1998 • 423 citations

Polypeptide Flux through Bacterial Hsp70

1999 • 421 citations

The fundamentals of protein folding: bringing together theory and experiment

1999 • 414 citations

A protein complex required for signal-sequence-specific sorting and translocation

1994 • 404 citations

Characterization of the Active Intermediate of a GroEL–GroES-Mediated Protein Folding Reaction

1996 • 403 citations

Recombination of protein domains facilitated by co-translational folding in eukaryotes

1997 • 400 citations

GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1

1997 • 397 citations

The Chaperonin ATPase Cycle: Mechanism of Allosteric Switching and Movements of Substrate-Binding Domains in GroEL

1996 • 385 citations

Protein folding in the central cavity of the GroEL–GroES chaperonin complex

1996 • 373 citations

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

2001 • 371 citations

Multistep mechanism of substrate binding determines chaperone activity of Hsp70.

2000 • 367 citations

In Vivo Observation of Polypeptide Flux through the Bacterial Chaperonin System

1997 • 345 citations

Folding in vivo of bacterial cytoplasmic proteins: Role of GroEL

1993 • 345 citations

In vivo newly translated polypeptides are sequestered in a protected folding environment

1999 • 333 citations

Structure of the Molecular Chaperone Prefoldin

2000 • 312 citations

Its substrate specificity characterizes the DnaJ co-chaperone as a scanning factor for the DnaK chaperone

2001 • 301 citations

A novel protein complex promoting formation of functional alpha - and gamma -tubulin

1998 • 296 citations

Chaperonin Function: Folding by Forced Unfolding

1999 • 294 citations

Dual Function of Protein Confinement in Chaperonin-Assisted Protein Folding

2001 • 290 citations

J Proteins Catalytically Activate Hsp70 Molecules to Trap a Wide Range of Peptide Sequences

1998 • 246 citations

Escherichia coli trigger factor is a prolyl isomerase that associates with nascent polypeptide chains.

1996 • 244 citations

The Crystal Structure of a GroEL/Peptide Complex

1999 • 241 citations

Review: Mechanisms of Disaggregation and Refolding of Stable Protein Aggregates by Molecular Chaperones

2001 • 237 citations

RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin

2001 • 225 citations

The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome–nascent chain complex

1998 • 224 citations

Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations

2000 • 217 citations

Compartmentation of protein folding invivo: sequestration of non-native polypeptide by the chaperonin-GimC system

1999 • 199 citations

Enzymes that catalyse the restructuring of proteins

2000 • 197 citations

Protein folding: progress made and promises ahead

2000 • 192 citations

Multivalent Binding of Nonnative Substrate Proteins by the Chaperonin GroEL

2000 • 191 citations

Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins

1999 • 191 citations

Structural insights into substrate binding by the molecular chaperone DnaK.

2000 • 190 citations

Binding specificity of Escherichia coli trigger factor

2001 • 180 citations

High-Throughput Proteomics: Protein Expression and Purification in the Postgenomic World

2001 • 175 citations

GroEL/GroES-Mediated Folding of a Protein Too Large to Be Encapsulated

2001 • 170 citations

The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1

2000 • 164 citations

Structure of the Substrate Binding Domain of the Thermosome, an Archaeal Group II Chaperonin

1997 • 162 citations

The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin

2001 • 148 citations

Co-translational folding of an alphavirus capsid protein in the cytosol of living cells

1999 • 147 citations

MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin

1999 • 146 citations

The effect of macromolecular crowding on chaperonin-mediated protein folding

1997 • 117 citations

The ins and outs of a molecular chaperone machine

1998 • 110 citations

The α and β Subunit of the Nascent Polypeptide-associated Complex Have Distinct Functions

2000 • 99 citations

The Interaction of the Chaperonin Tailless Complex Polypeptide 1 (Tcp1) Ring Complex (Tric) with Ribosome-Bound Nascent Chains Examined Using Photo-Cross-Linking

2000 • 94 citations

Folding of malate dehydrogenase inside the GroEL-GroES cavity.

2001 • 84 citations

Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins

1998 • 82 citations

Molecular chaperones: Inside and outside the Anfinsen cage

2001 • 52 citations

Folding of Firefly (Photinus pyralis) Luciferase: Aggregation and Reactivation of Unfolding Intermediates

1998 • 50 citations

ATP-Induced Structural Change of the Thermosome Is Temperature-Dependent

2001 • 43 citations

GroEL recognises sequential and non-sequential linear structural motifs compatible with extended β-strands and α-helices 1 1Edited by J. Karn

1999 • 43 citations

Protein folding and molecular chaperones in Archaea

2001 • 17 citations