A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Hsp90 as a capacitor of phenotypic variation

2002 • 1,347 citations

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

1997 • 1,345 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Modulation of Akt kinase activity by binding to Hsp90

2000 • 942 citations

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo

1998 • 709 citations

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis

1998 • 584 citations

Heat shock protein 90 as a molecular target for cancer therapeutics

2003 • 572 citations

Hsp90: Chaperoning signal transduction

2001 • 569 citations

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1998 • 474 citations

Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

1996 • 460 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

2002 • 427 citations

Sensitivity of Mature ErbB2 to Geldanamycin Is Conferred by Its Kinase Domain and Is Mediated by the Chaperone Protein Hsp90

2001 • 354 citations

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

1985 • 304 citations

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

2001 • 282 citations

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2

2002 • 269 citations

The Heat Shock Protein 90 Antagonist Geldanamycin Alters Chaperone Association with p210bcr-abl and v-src Proteins before Their Degradation by the Proteasome

2000 • 269 citations

The Assembly of Progesterone Receptor-hsp90 Complexes Using Purified Proteins

1998 • 239 citations

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

2002 • 236 citations

The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes

1999 • 224 citations

Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome

1997 • 193 citations

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

1995 • 185 citations

17AAG: low target binding affinity and potent cell activity--finding an explanation.

2003 • 151 citations

Expression and Roles of Heat Shock Proteins in Human Breast Cancer

1996 • 118 citations

Differential expression of heat shock proteins in pancreatic carcinoma.

1994 • 117 citations

Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins.

1994 • 115 citations

Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics.

2003 • 108 citations

Telomerase as a Target for Cancer Immunotherapy

2003 • 47 citations

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