Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

2011 • 2,642 citations

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

2008 • 2,492 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

Guidelines for the welfare and use of animals in cancer research

2010 • 1,305 citations

Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

2011 • 880 citations

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

2004 • 873 citations

Targeted expression of MYCN causes neuroblastoma in transgenic mice

1997 • 830 citations

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

2004 • 758 citations

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

2004 • 750 citations

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

2008 • 710 citations

Aurora-A — A guardian of poles

2005 • 670 citations

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

2008 • 558 citations

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

2009 • 518 citations

The ubiquitin-specific protease USP28 is required for MYC stability

2007 • 422 citations

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

2007 • 410 citations

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter

2001 • 334 citations

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

2005 • 314 citations

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

2002 • 306 citations

A Mouse Model of the Most Aggressive Subgroup of Human Medulloblastoma

2012 • 285 citations

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

2011 • 274 citations

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

2012 • 219 citations

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

2005 • 199 citations

Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification

2005 • 180 citations

Endogenous Myc maintains the tumor microenvironment

2011 • 180 citations

N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth

2006 • 155 citations

The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells.

1991 • 148 citations

The Cdk1 Complex Plays a Prime Role in Regulating N-Myc Phosphorylation and Turnover in Neural Precursors

2005 • 140 citations

Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma

2012 • 131 citations

Prognostic Impact of Gene Expression–Based Classification for Neuroblastoma

2010 • 129 citations

MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel

2010 • 112 citations

Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237

2010 • 110 citations

Lack of Cyclin-Dependent Kinase 4 Inhibits c-myc Tumorigenic Activities in Epithelial Tissues

2004 • 99 citations

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

2010 • 95 citations

Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma

2009 • 87 citations

Paracrine Signaling Through MYCN Enhances Tumor-Vascular Interactions in Neuroblastoma

2012 • 80 citations

The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and SensitizesMYCN-Amplified NeuroblastomaIn Vivo

2011 • 76 citations

A sense of closeness: protein detection by proximity ligation

2003 • 75 citations

Functional Interaction of Aurora-A and PP2A during Mitosis

2007 • 57 citations