The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and SensitizesMYCN-Amplified NeuroblastomaIn Vivo

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2003 • 2,027 citations

Neuroblastoma

2007 • 1,855 citations

Guidelines for the welfare and use of animals in cancer research

2010 • 1,305 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • 847 citations

Targeted expression of MYCN causes neuroblastoma in transgenic mice

1997 • 830 citations

Aurora-A — A guardian of poles

2005 • 670 citations

Aurora-kinase inhibitors as anticancer agents

2004 • 658 citations

Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

2003 • 591 citations

Roles of Aurora Kinases in Mitosis and Tumorigenesis

2007 • 583 citations

Shared and separate functions of polo-like kinases and aurora kinases in cancer

2010 • 563 citations

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

2009 • 518 citations

Aurora-A: the maker and breaker of spindle poles

2007 • 425 citations

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

2007 • 410 citations

Mechanism of Aurora B Activation by INCENP and Inhibition by Hesperadin

2005 • 378 citations

Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

2002 • 345 citations

Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma

2004 • 302 citations

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

2005 • 252 citations

Initial testing of the aurora kinase a inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)

2010 • 220 citations

Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma

2006 • 192 citations

Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents

2009 • 174 citations

Overexpression of the Centrosomal Protein Aurora-A Kinase is Associated with Poor Prognosis in Epithelial Ovarian Cancer Patients

2007 • 146 citations

The Cdk1 Complex Plays a Prime Role in Regulating N-Myc Phosphorylation and Turnover in Neural Precursors

2005 • 140 citations

The aurora kinase A regulates GSK-3β in gastric cancer cells

2008 • 134 citations

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A Activity

2007 • 119 citations

Childhood tumors of the nervous system as disorders of normal development

2006 • 112 citations

Effects of MYCN Antisense Oligonucleotide Administration on Tumorigenesis in a Murine Model of Neuroblastoma

2003 • 102 citations

Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias

2010 • 94 citations

Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer

2011 • 92 citations

Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies toward the Identification of an Orally Bioavailable Preclinical Development Candidate

2010 • 79 citations

Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity

2007 • 66 citations

Aurora kinase inhibitors: identification and preclinical validation of their biomarkers

2007 • 57 citations

A Cancer-associated Aurora A Mutant Is Mislocalized and Misregulated Due to Loss of Interaction with TPX2

2009 • 43 citations

Dual Inhibition of Aurora and FLT3 Kinases by CCT137690: A Novel Treatment Strategy Against FLT3-ITD Positive AML In Vitro and In Vivo

2010 • 3 citations