MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Aurora-A — A guardian of poles

2005 • 670 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

2007 • 410 citations

Aurora Kinases as Anticancer Drug Targets

2008 • 383 citations

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

2003 • 361 citations

Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

2002 • 345 citations

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

2007 • 342 citations

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

2003 • 318 citations

The chromosomal passenger complex: guiding Aurora-B through mitosis

2006 • 281 citations

Validating Aurora B as an anti-cancer drug target

2006 • 279 citations

Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

2005 • 268 citations

Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation

2006 • 241 citations

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

2007 • 239 citations

RNA Interference Targeting Aurora Kinase A Suppresses Tumor Growth and Enhances the Taxane Chemosensitivity in Human Pancreatic Cancer Cells

2005 • 217 citations

Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions

2006 • 179 citations

Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents

2009 • 174 citations

Expression of Aurora A (but Not Aurora B) Is Predictive of Survival in Breast Cancer

2008 • 129 citations

Predictive factors for response to docetaxel in human breast cancers

2006 • 123 citations

Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

2005 • 116 citations

Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis

2004 • 103 citations

The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model

2009 • 75 citations

Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells

2008 • 72 citations

Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma

2008 • 65 citations

Targeting Aurora Kinase with MK-0457 Inhibits Ovarian Cancer Growth

2008 • 64 citations

The Suppression of Aurora-A/STK15/BTAK Expression Enhances Chemosensitivity to Docetaxel in Human Esophageal Squamous Cell Carcinoma

2007 • 53 citations

Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice

2008 • 53 citations

Aurora-A Transcriptional Silencing and Vincristine Treatment Show a Synergistic Effect in Human Tumor Cells

2008 • 26 citations