Aurora-A — A guardian of poles

Cancer genes and the pathways they control

2004 • 4,172 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

Signaling to Chromatin through Histone Modifications

2000 • 987 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Stuck in Division or Passing through

2004 • 630 citations

Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

2001 • 616 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

2003 • 570 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

1999 • 492 citations

The Mitotic Spindle: A Self-Made Machine

2001 • 447 citations

Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity

2004 • 443 citations

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

2001 • 417 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA

2000 • 373 citations

Tpx2, a Novel Xenopus Map Involved in Spindle Pole Organization

2000 • 363 citations

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

2003 • 361 citations

A Novel Mechanism for Activation of the Protein Kinase Aurora A

2003 • 358 citations

The Ran GTPase regulates mitotic spindle assembly

1999 • 349 citations

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

2003 • 341 citations

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

1999 • 333 citations

Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.

2003 • 329 citations

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.

1998 • 324 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer.

2000 • 319 citations

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

2003 • 318 citations

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

2001 • 317 citations

Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215

2004 • 307 citations

INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow

2000 • 307 citations

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.

1999 • 306 citations

Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma

2004 • 302 citations

Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis

2000 • 301 citations

Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer.

2003 • 300 citations

Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

2003 • 298 citations

Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

2002 • 295 citations

Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability.

2002 • 288 citations

Mitotic mechanics: the auroras come into view

2003 • 269 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1

1997 • 265 citations

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition

2004 • 265 citations

Phosphorylation of the Carboxyl Terminus of Inner Centromere Protein (INCENP) by the Aurora B Kinase Stimulates Aurora B Kinase Activity

2002 • 262 citations

Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis

2002 • 257 citations

Model for the genetic evolution of human solid tumors.

1989 • 251 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly

1998 • 240 citations

CENP-A Phosphorylation by Aurora-A in Prophase Is Required for Enrichment of Aurora-B at Inner Centromeres and for Kinetochore Function

2003 • 238 citations

The Aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis

2000 • 235 citations

Association of centrosomal kinaseSTK15/BTAK mRNA expression with chromosomal instability in human breast cancers

2001 • 231 citations

G1 tetraploidy checkpoint and the suppression of tumorigenesis

2002 • 226 citations

The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5

1999 • 218 citations

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

2001 • 211 citations

Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells

2002 • 208 citations

The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis

2002 • 206 citations

Aurora-B Regulates the Cleavage Furrow-specific Vimentin Phosphorylation in the Cytokinetic Process

2003 • 201 citations

DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.

1997 • 198 citations

Localization of the Kinesin-like Protein Xklp2 to Spindle Poles Requires a Leucine Zipper, a Microtubule-associated Protein, and Dynein

1998 • 196 citations

Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle

2001 • 189 citations

Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis.

2002 • 182 citations

Mitotic Kinase Expression and Colorectal Cancer Progression

1999 • 177 citations

p21^Waf1/Cip1 Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption

1999 • 171 citations

p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

1998 • 168 citations

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

2004 • 159 citations

The LIM Protein Ajuba Is Recruited to Cadherin-dependent Cell Junctions through an Association with α-Catenin

2003 • 151 citations

Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway

2000 • 146 citations

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

2004 • 144 citations

hTPX2 Is Required for Normal Spindle Morphology and Centrosome Integrity during Vertebrate Cell Division

2002 • 142 citations

TAC-1 and ZYG-9 Form a Complex that Promotes Microtubule Assembly in C. elegans Embryos

2003 • 141 citations

Direct Association with Inner Centromere Protein (INCENP) Activates the Novel Chromosomal Passenger Protein, Aurora-C

2004 • 140 citations

Sli15 Associates with the Ipl1 Protein Kinase to Promote Proper Chromosome Segregation in Saccharomyces cerevisiae

1999 • 139 citations

Aurora-A Kinase Regulates Telomerase Activity through c-Myc in Human Ovarian and Breast Epithelial Cells

2004 • 122 citations

Centrosomal Kinases, HsAIRK1 and HsAIRK3, are Overexpressed in Primary Colorectal Cancers

2000 • 114 citations

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

2002 • 111 citations

p53-Independent Apoptosis and p53-Dependent Block of DNA Rereplication Following Mitotic Spindle Inhibition in Human Cells

1999 • 104 citations

Functional Significance of the Specific Sites Phosphorylated in Desmin at Cleavage Furrow: Aurora-B May Phosphorylate and Regulate Type III Intermediate Filaments during Cytokinesis Coordinatedly with Rho-kinase

2003 • 103 citations

TACC1–chTOG–Aurora A protein complex in breast cancer

2003 • 99 citations

The D‐Box‐activating domain (DAD) is a new proteolysis signal that stimulates the silent D‐Box sequence of Aurora‐A

2002 • 89 citations

The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer

2004 • 77 citations

Myosin II Regulatory Light Chain as a Novel Substrate for AIM-1, an Aurora/Ipl1p-related Kinase from Rat

2000 • 70 citations

STK15 Polymorphisms and Association with Risk of Invasive Ovarian Cancer

2004 • 70 citations

Genomic Organization, Expression, and Chromosome Localization of a Third Aurora-Related Kinase Gene,Aie1

2000 • 68 citations

The Xenopus laevis Aurora/Ip11p-Related Kinase pEg2 Participates in the Stability of the Bipolar Mitotic Spindle

2000 • 67 citations

AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer

2003 • 61 citations

Downregulation of an Aim-1 Kinase Couples with Megakaryocytic Polyploidization of Human Hematopoietic Cells

2001 • 58 citations

STK15 polymorphism and breast cancer risk in a population-based study

2004 • 57 citations

Differentially Regulated Genes as Putative Targets of Amplifications at 20q in Ovarian Cancers

2002 • 55 citations

Megakaryocytes express functional Aurora-B kinase in endomitosis

2004 • 52 citations

Involvement of Aurora A Kinase during Meiosis I-II Transition inXenopus Oocytes

2003 • 48 citations

Identification of Aurora Kinases as RasGAP Src Homology 3 Domain-binding Proteins

2002 • 42 citations

The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1

2002 • 39 citations

Aurora-A Overexpression Leads to Override of the Microtubule-Kinetochore Attachment Checkpoint

2003 • 20 citations