Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

PHENIX: building new software for automated crystallographic structure determination

2002 • 4,243 citations

Patterns of somatic mutation in human cancer genomes

2007 • 2,975 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

Targeting cancer with small molecule kinase inhibitors

2008 • 2,437 citations

A quantitative analysis of kinase inhibitor selectivity

2008 • 2,334 citations

Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase

2000 • 1,770 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

Rational design of inhibitors that bind to inactive kinase conformations

2006 • 1,013 citations

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

2002 • 818 citations

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

2006 • 712 citations

Aurora-kinase inhibitors as anticancer agents

2004 • 658 citations

Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

2003 • 591 citations

Targeted anti-mitotic therapies: can we improve on tubulin agents?

2007 • 465 citations

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

2007 • 410 citations

Mechanism of Aurora B Activation by INCENP and Inhibition by Hesperadin

2005 • 378 citations

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

2003 • 318 citations

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

2008 • 306 citations

Overexpression and Amplification of Aurora-A in Hepatocellular Carcinoma

2004 • 302 citations

c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty

2007 • 215 citations

Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents

2009 • 174 citations

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

2005 • 126 citations

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A Activity

2007 • 119 citations

Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation

2008 • 87 citations

A Class of 2,4-Bisanilinopyrimidine Aurora A Inhibitors with Unusually High Selectivity against Aurora B

2009 • 80 citations

Hit generation and exploration: Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

2007 • 75 citations

Structure-based design of molecular cancer therapeutics

2009 • 66 citations

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

2008 • 51 citations