Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

Neuroblastoma: Biology, Prognosis, and Treatment

2010 • 538 citations

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

2009 • 518 citations

Lancet Oncol 10

2013 • 433 citations

An alternative pathway for gene regulation by Myc

1997 • 365 citations

Gene expression analyses reveal molecular relationships among 20 regions of the human CNS

2006 • 336 citations

Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

1996 • 307 citations

Customized Oligonucleotide Microarray Gene Expression–Based Classification of Neuroblastoma Patients Outperforms Current Clinical Risk Stratification

2006 • 283 citations

MYCN regulates oncogenic MicroRNAs in neuroblastoma

2007 • 258 citations

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

2008 • 251 citations

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors

2003 • 206 citations

Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in Neuroblastoma

2006 • 192 citations

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

2009 • 191 citations

A Mouse PRMT1 Null Allele Defines an Essential Role for Arginine Methylation in Genome Maintenance and Cell Proliferation

2009 • 184 citations

High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma

2008 • 169 citations

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

2009 • 158 citations

Expression profiling using a tumor-specific cDNA microarray predicts the prognosis of intermediate risk neuroblastomas

2005 • 152 citations

MYCN-regulated microRNAs repress estrogen receptor-α ( ESR1 ) expression and neuronal differentiation in human neuroblastoma

2010 • 131 citations

Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling

2005 • 119 citations

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

2010 • 108 citations

MYCN oncoprotein targets and their therapeutic potential

2010 • 99 citations

MYCN protein expression as a predictor of neuroblastoma prognosis.

1997 • 99 citations

Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data

2007 • 94 citations

A SP1/MIZ1/MYCN Repression Complex Recruits HDAC1 at theTRKAandp75NTRPromoters and Affects Neuroblastoma Malignancy by Inhibiting the Cell Response to NGF

2010 • 91 citations

Conditional expression of retrovirally delivered anti-MYCN shRNA as an in vitro model system to study neuronal differentiation in MYCN-amplified neuroblastoma

2011 • 90 citations

Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo

2011 • 59 citations

Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma

2007 • 46 citations

Characterization of amplicons in neuroblastoma: High-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes

2008 • 45 citations

Immunohistochemical analysis of N-myc protein expression in neuroblastoma: Correlation with prognosis of patients

1991 • 44 citations

Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma

2007 • 44 citations

Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes

2007 • 33 citations

Classification of neuroblastoma patients by published gene-expression markers reveals a low sensitivity for unfavorable courses of MYCN non-amplified disease

2006 • 21 citations

Stable knockdown of MYCN by lentivirus-based RNAi inhibits human neuroblastoma cells growth in vitro and in vivo

2011 • 20 citations