The cellular geography of Aurora kinases

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • 847 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections

2002 • 725 citations

Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors

1999 • 703 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.

1988 • 640 citations

Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases

2002 • 636 citations

Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

2001 • 616 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Phospho-Regulation of Kinetochore-Microtubule Attachments by the Aurora Kinase Ipl1p

2002 • 612 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Chromosomal passengers and the (aurora) ABCs of mitosis

2001 • 535 citations

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

2000 • 534 citations

Histone Phosphorylation and Chromatin Structure during Mitosis in Chinese Hamster Cells

1978 • 534 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

Exploring the Functional Interactions between Aurora B, INCENP, and Survivin in Mitosis

2003 • 495 citations

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

1999 • 492 citations

Essential Roles of Drosophila Inner Centromere Protein (Incenp) and Aurora B in Histone H3 Phosphorylation, Metaphase Chromosome Alignment, Kinetochore Disjunction, and Chromosome Segregation

2001 • 457 citations

Identification of a Novel Phosphorylation Site on Histone H3 Coupled with Mitotic Chromosome Condensation

1999 • 446 citations

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

2001 • 417 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

2001 • 411 citations

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

1999 • 404 citations

Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran

1999 • 393 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

Cyk-4

2000 • 386 citations

Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA

2000 • 373 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Tpx2, a Novel Xenopus Map Involved in Spindle Pole Organization

2000 • 363 citations

A Novel Mechanism for Activation of the Protein Kinase Aurora A

2003 • 358 citations

The Ran GTPase regulates mitotic spindle assembly

1999 • 349 citations

Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

2002 • 345 citations

Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint.

1995 • 344 citations

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

2003 • 341 citations

Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

2003 • 325 citations

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.

1998 • 324 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis

2002 • 320 citations

Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells

2002 • 319 citations

Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer.

2000 • 319 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

Aurora B Kinase Exists in a Complex with Survivin and INCENP and Its Kinase Activity Is Stimulated by Survivin Binding and Phosphorylation

2002 • 318 citations

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

2001 • 317 citations

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

2003 • 312 citations

INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow

2000 • 307 citations

Inhibition of Aurora B Kinase Blocks Chromosome Segregation, Overrides the Spindle Checkpoint, and Perturbs Microtubule Dynamics in Mitosis

2002 • 307 citations

AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos

1998 • 303 citations

Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

1993 • 301 citations

Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis

2000 • 301 citations

The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair

2002 • 301 citations

Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

2003 • 298 citations

Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

2002 • 295 citations

Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability.

2002 • 288 citations

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

2000 • 281 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 280 citations

Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.

1994 • 271 citations

Scc1/Rad21/Mcd1 Is Required for Sister Chromatid Cohesion and Kinetochore Function in Vertebrate Cells

2001 • 267 citations

Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

1996 • 266 citations

Phosphorylation of the Carboxyl Terminus of Inner Centromere Protein (INCENP) by the Aurora B Kinase Stimulates Aurora B Kinase Activity

2002 • 262 citations

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

2001 • 261 citations

Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis

2002 • 257 citations

The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone

2000 • 252 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

Chromatin-associated Protein Phosphatase 1 Regulates Aurora-B and Histone H3 Phosphorylation

2001 • 246 citations

The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly

1998 • 240 citations

The Aurora B Kinase AIR-2 Regulates Kinetochores during Mitosis and Is Required for Separation of Homologous Chromosomes during Meiosis

2002 • 235 citations

The Aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis

2000 • 235 citations

A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs

1993 • 230 citations

Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A

2002 • 223 citations

The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5

1999 • 218 citations

Structures of the Cancer-Related Aurora-A, FAK, and EphA2 Protein Kinases from Nanovolume Crystallography

2002 • 210 citations

INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1

1998 • 208 citations

The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis

2002 • 206 citations

Aurora-B Regulates the Cleavage Furrow-specific Vimentin Phosphorylation in the Cytokinetic Process

2003 • 201 citations

Chromosomal passengers: Toward an integrated view of mitosis

1991 • 198 citations

Probing the Dynamics and Functions of Aurora B Kinase in Living Cells during Mitosis and Cytokinesis

2002 • 195 citations

Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase

2002 • 191 citations

Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle

2001 • 189 citations

The Kinase Activity of Aurora B Is Required for Kinetochore-Microtubule Interactions during Mitosis

2002 • 188 citations

A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos

1998 • 184 citations

p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

1998 • 168 citations

Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)–related protein Sli15 during chromosome segregation

2001 • 165 citations

Chromosome micromanipulation

1967 • 164 citations

APC/Fizzy‐Related targets Aurora‐A kinase for proteolysis

2002 • 162 citations

A Dominant Mutant of Inner Centromere Protein (INCENP), a Chromosomal Protein, Disrupts Prometaphase Congression and Cytokinesis

1998 • 151 citations

Aurora-B associated protein phosphatases as negative regulators of kinase activation

2002 • 151 citations

The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway

1998 • 147 citations

Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway

2000 • 146 citations

The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly

2003 • 146 citations

TheS. pombeaurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation

2001 • 141 citations

S. pombe Aurora Kinase/Survivin Is Required for Chromosome Condensation and the Spindle Checkpoint Attachment Response

2003 • 140 citations

ISWI Remodeling Complexes inXenopusEgg Extracts: Identification as Major Chromosomal Components that Are Regulated by INCENP-aurora B

2002 • 140 citations

Protein Kinase Profile of Sperm and Eggs: Cloning and Characterization of Two Novel Testis-Specific Protein Kinases (AIE1, AIE2) Related to Yeast and Fly Chromosome Segregation Regulators

1998 • 135 citations

Survivin Enhances Aurora-B Kinase Activity and Localizes Aurora-B in Human Cells

2002 • 122 citations

Kinetochore Protein Interactions and their Regulation by the Aurora Kinase Ipl1p

2003 • 120 citations

The Mammalian Passenger Protein TD-60 Is an RCC1 Family Member with an Essential Role in Prometaphase to Metaphase Progression

2003 • 119 citations

An Inner Centromere Protein that Stimulates the Microtubule Depolymerizing Activity of a KinI Kinesin

2003 • 115 citations

Centrosomal Kinases, HsAIRK1 and HsAIRK3, are Overexpressed in Primary Colorectal Cancers

2000 • 114 citations

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

2002 • 111 citations

p53-Independent Apoptosis and p53-Dependent Block of DNA Rereplication Following Mitotic Spindle Inhibition in Human Cells

1999 • 104 citations

Functional Significance of the Specific Sites Phosphorylated in Desmin at Cleavage Furrow: Aurora-B May Phosphorylate and Regulate Type III Intermediate Filaments during Cytokinesis Coordinatedly with Rho-kinase

2003 • 103 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI)

1994 • 100 citations

CSC-1

2003 • 96 citations

Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair

2001 • 95 citations

The D‐Box‐activating domain (DAD) is a new proteolysis signal that stimulates the silent D‐Box sequence of Aurora‐A

2002 • 89 citations

Cloning of STK13, a Third Human Protein Kinase Related toDrosophilaAurora and Budding Yeast Ipl1 That Maps on Chromosome 19q13.3–ter

1998 • 89 citations

TheSchizosaccharomyces pombeAurora–related Kinase Ark1 Interacts with the Inner Centromere Protein Pic1 and Mediates Chromosome Segregation and Cytokinesis

2002 • 86 citations

Duplicating Dangerously

2002 • 82 citations

Progesterone regulates the accumulation and the activation of Eg2 kinase in Xenopus oocytes

2000 • 76 citations

INCENP Binds Directly to Tubulin and Requires Dynamic Microtubules to Target to the Cleavage Furrow

2001 • 71 citations

Myosin II Regulatory Light Chain as a Novel Substrate for AIM-1, an Aurora/Ipl1p-related Kinase from Rat

2000 • 70 citations

Genomic Organization, Expression, and Chromosome Localization of a Third Aurora-Related Kinase Gene,Aie1

2000 • 68 citations

The Xenopus laevis Aurora/Ip11p-Related Kinase pEg2 Participates in the Stability of the Bipolar Mitotic Spindle

2000 • 67 citations

Cdc2-Cyclin B Triggers H3 Kinase Activation of Aurora-A in Xenopus Oocytes

2003 • 60 citations

Molecular Dynamics of Aurora-A Kinase in Living Mitotic Cells Simultaneously Visualized with Histone H3 and Nuclear Membrane Protein Importin.ALPHA..

2002 • 56 citations

Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis

1998 • 52 citations

The non-catalytic domain of the Xenopus laevis auroraA kinase localises the protein to the centrosome

2001 • 51 citations

Involvement of Aurora A Kinase during Meiosis I-II Transition inXenopus Oocytes

2003 • 48 citations

Aurora-A Kinase Interacting Protein (AIP), a Novel Negative Regulator of Human Aurora-A Kinase

2002 • 44 citations

Identification of Aurora Kinases as RasGAP Src Homology 3 Domain-binding Proteins

2002 • 42 citations