The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

1996 • 900 citations

A human peptidyl–prolyl isomerase essential for regulation of mitosis

1996 • 891 citations

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

1991 • 870 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

1995 • 658 citations

Monoclonal antibodies to mitotic cells.

1983 • 609 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1998 • 488 citations

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

1995 • 471 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts.

1992 • 419 citations

γ-Tubulin is present in Drosophila melanogaster and homo sapiens and is associated with the centrosome

1991 • 405 citations

polo encodes a protein kinase homolog required for mitosis in Drosophila.

1991 • 403 citations

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase.

1991 • 384 citations

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

1995 • 376 citations

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

1995 • 369 citations

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

1998 • 340 citations

Cell cycle regulation of a Xenopus Wee1-like kinase.

1995 • 316 citations

PKA and MPF-Activated Polo-like Kinase Regulate Anaphase-Promoting Complex Activity and Mitosis Progression

1998 • 309 citations

Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle

1994 • 303 citations

Induction and down-regulation of PLK, a humanserine/threonine kinase expressed in proliferating cells andtumors.

1994 • 278 citations

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5

1994 • 275 citations

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

1993 • 270 citations

Plk Is an M-Phase-Specific Protein Kinase and Interacts with a Kinesin-Like Protein, CHO1/MKLP-1

1995 • 266 citations

The cdc25 M-phase inducer: An unconventional protein phosphatase

1992 • 266 citations

Functional analysis of the chromo domain of HP1.

1995 • 259 citations

Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.

1994 • 257 citations

Phosphoproteins are components of mitotic microtubule organizing centers.

1984 • 246 citations

Differential expression of a phosphoepitope at the kinetochores of moving chromosomes

1993 • 231 citations

Systematic identification of mitotic phosphoproteins

1997 • 225 citations

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts

1998 • 214 citations

Identification by Targeted Differential Display of an Immediate Early Gene Encoding a Putative Serine/Threonine Kinase

1995 • 196 citations

Identification of an Early-Growth-Response Gene Encoding a Novel Putative Protein Kinase

1992 • 187 citations

Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation

1991 • 176 citations

Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

1995 • 165 citations

DNA topoisomerase II alpha is the major chromosome protein recognized by the mitotic phosphoprotein antibody MPM-2.

1993 • 162 citations

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.

1993 • 158 citations

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

1995 • 148 citations

prk, a Cytokine-inducible Human Protein Serine/Threonine Kinase Whose Expression Appears to be Down-regulated in Lung Carcinomas

1996 • 148 citations

A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos

1993 • 128 citations

The Homeotic Target Gene centrosomin Encodes an Essential Centrosomal Component

1996 • 127 citations

The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.

1992 • 127 citations

Proteins of the mammalian mitotic spindle: phosphorylation/dephosphorylation of MAP-4 during mitosis

1991 • 121 citations

Distribution of cytoskeletal proteins sharing a conserved phosphorylated epitope.

1986 • 118 citations

Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase.

1994 • 116 citations

Human Prk Is a Conserved Protein Serine/Threonine Kinase Involved in Regulating M Phase Functions

1997 • 112 citations

Conservation of the Centromere/Kinetochore Protein ZW10

1997 • 109 citations

Nucleation of microtubules from mitotic centrosomes is modulated by a phosphorylated epitope

1990 • 108 citations

Functional Components Of Microtubule-Organizing Centers

1992 • 95 citations

A dependent pathway of gene functions leading to chromosome segregation in Saccharomyces cerevisiae.

1982 • 92 citations

Cell Cycle- and Terminal Differentiation-Associated Regulation of the Mouse mRNA Encoding a Conserved Mitotic Protein Kinase

1993 • 86 citations

The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extracts.

1996 • 84 citations

At least two kinases phosphorylate the MPM-2 epitope during Xenopus oocyte maturation.

1993 • 79 citations

Cell‐cycle modulation of MPM‐2‐specific spindle pole body phosphorylation in Aspergillus nidulans

1988 • 71 citations

Determinants of Drosophila zw10 protein localization and function

1994 • 68 citations

Specific association of an M-phase kinase with isolated mitotic spindles and identification of two of its substrates as MAP4 and MAP1B.

1991 • 64 citations

Mitotic spindle morphogenesis in animal cells.

1991 • 57 citations

MPM-2 antibody-reactive phosphorylations can be created in detergentextracted cells by kinetochore-bound and soluble kinases

1997 • 35 citations

The distribution of a ‘mitosis-specific’ antigen during Drosophila development

1987 • 25 citations

Cell-Cycle-Regulated Localization of Tyrosine and Threonine Phosphoepitopes at the Kinetochores of Mitotic Chromosomes

1995 • 25 citations

Mitotic phosphoepitopes are expressed in Kc cells, neuroblasts and isolated chromosomes of Drosophila melanogaster

1997 • 21 citations