Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8⁺T cells in influenza virus-infected mice

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Virus-Specific CD8+ T Cells in Primary and Secondary Influenza Pneumonia

1998 • 685 citations

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

1997 • 493 citations

Effector CD4⁺ and CD8⁺ T‐cell mechanisms in the control of respiratory virus infections

1997 • 430 citations

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

1996 • 401 citations

Dipeptidyl peptidase I is required for the processing and activation of granzymes A and Bin vivo

1999 • 389 citations

Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.

1991 • 372 citations

The Immune Response to Influenza Infection

1986 • 321 citations

Cytotoxic Cell Granule-Mediated Apoptosis

2002 • 297 citations

A Previously Unrecognized H-2D^b-Restricted Peptide Prominent in the Primary Influenza A Virus-Specific CD8⁺T-Cell Response Is Much Less Apparent following Secondary Challenge

2000 • 260 citations

Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

1999 • 259 citations

Response to influenza infection in mice with a targeted disruption in the interferon gamma gene.

1993 • 247 citations

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

1999 • 207 citations

Diversity of Epitope and Cytokine Profiles for Primary and Secondary Influenza A Virus-Specific CD8+ T Cell Responses

2001 • 207 citations

Immune interferon release when a cloned cytotoxic T-cell line meets its correct influenza-infected target cell

1982 • 202 citations

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain

1997 • 195 citations

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

1997 • 192 citations

The Role of Alpha/Beta and Gamma Interferons in Development of Immunity to Influenza A Virus in Mice

2000 • 190 citations

Unlocking the secrets of cytotoxic granule proteins

2001 • 177 citations

Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells

1998 • 171 citations

Expression of perforin and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells

1991 • 166 citations

Granzyme A Initiates an Alternative Pathway for Granule-Mediated Apoptosis

1999 • 163 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

Recruitment and proliferation of CD8+ T cells in respiratory virus infections.

1995 • 130 citations

In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue

1996 • 126 citations

Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected mice

1995 • 118 citations

The genes for perforin, granzymes A–C and IFN‐γ are differentially expressed in single CD8+ T cells during primary activation

2002 • 103 citations

Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10

1994 • 99 citations

Systemic T cell expansion during localized viral infection

1999 • 87 citations

A Clonal Culture System Demonstrates That IL-4 Induces a Subpopulation of Noncytolytic T Cells with Low CD8, Perforin, and Granzyme Expression

2002 • 77 citations

Alveolar macrophages regulate the induction of primary cytotoxic T-lymphocyte responses during influenza virus infection

1997 • 72 citations

The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells

2002 • 63 citations

Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations

1999 • 61 citations

A single peripheral CD8⁺T cell can give rise to progeny expressing type 1 and/or type 2 cytokine genes and can retain its multipotentiality through many cell divisions

1997 • 61 citations

Enumeration of lymphokine mRNA-containing cells in vivo in a murine graft-versus-host reaction using the PCR.

1992 • 59 citations

Quantitative polymerase chain reaction analysis of cytotoxic cell proteinase gene transcripts in T cells. Pattern of expression is dependent on the nature of the stimulus.

1992 • 58 citations

Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection

1996 • 54 citations

In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C

1991 • 44 citations

T Lymphocyte-Derived Colony-Stimulating Factors

1990 • 39 citations

Inactivation and proteolytic degradation of perforin within lytic granules upon neutralization of acidic pH

1997 • 37 citations

The Activated Type 1–Polarized Cd8+ T Cell Population Isolated from an Effector Site Contains Cells with Flexible Cytokine Profiles

1999 • 33 citations

Nephritogenic T cells use granzyme C as a cytotoxic mediator

1997 • 18 citations