The Roles of IL-12 in Providing a Third Signal for Clonal Expansion of Naive CD8 T Cells

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

1998 • 785 citations

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

1996 • 690 citations

Comparison of three actin-coding sequences in the mouse; Evolutionary relationships between the actin genes of warm-blooded vertebrates

1986 • 678 citations

Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells

2001 • 584 citations

Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells

1999 • 580 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets

2001 • 496 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

1997 • 263 citations

Molecules involved in T-cell costimulation

1993 • 237 citations

Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

1997 • 205 citations

Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

1984 • 183 citations

CD8+ Memory T Cells (CD44high, Ly-6C+) Are More Sensitive than Naive Cells (CD44low, Ly-6C−) to TCR/CD8 Signaling in Response to Antigen

1998 • 177 citations

The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation

2001 • 152 citations

Differential Associations between the Cytoplasmic Regions of the Interleukin-12 Receptor Subunits β1 and β2 and JAK Kinases

1997 • 142 citations

Adjuvant Effect of IL-12: Conversion of Peptide Antigen Administration from Tolerizing to Immunizing for CD8+ T Cells In Vivo

1999 • 138 citations

Peptide Antigen Priming of Naive, But Not Memory, CD8 T Cells Requires a Third Signal That Can Be Provided by IL-12

2002 • 130 citations

Homeostatic Expansion Occurs Independently of Costimulatory Signals

2001 • 124 citations

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

2000 • 122 citations

IL-12 Enhances CD8 T Cell Homeostatic Expansion

2001 • 121 citations

Prolonged IL-2 receptor alpha/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. Demonstration of combined transcriptional and post-transcriptional regulation.

1992 • 115 citations

Molecular mechanisms underlying functional T-cell unresponsiveness

1995 • 115 citations

Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone.

1994 • 106 citations

Altered Interleukin-12 Responsiveness in Th1 and Th2 Cells Is Associated With the Differential Activation of STAT5 and STAT1

1998 • 78 citations

B7‐1‐dependent co‐stimulation results in qualitatively and quantitatively different responses by CD4⁺ and CD8⁺ T cells

1997 • 77 citations

CD28 costimulation up-regulates long-term IL-2R beta expression in human T cells through combined transcriptional and post-transcriptional regulation.

1995 • 61 citations

Role of Costimulation in the Induction of the IL-12/IL-12 Receptor Pathway and the Development of Autoimmunity

2000 • 59 citations

Activation of antigen-specific T cells by artificial cell constructs having immobilized multimeric peptide–class I complexes and recombinant B7–Fc proteins

2001 • 49 citations

IL-12 receptor (IL-12R) expression and accumulation of IL-12R beta 1 and IL-12R beta 2 mRNAs in CD4+ T cells by costimulation with B7-2 molecules.

1998 • 47 citations

IL-12 Receptor (IL-12R) Expression and Accumulation of IL-12Rβ1 and IL-12Rβ2 mRNAs in CD4+ T Cells by Costimulation with B7-2 Molecules

1998 • 40 citations

IL-12 enhances IL-2 function by inducing CD25 expression through a p38 mitogen-activated protein kinase pathway

2000 • 40 citations

Lack of intermediate‐affinity interleukin‐2 receptor in mice leads to dependence on interleukin‐2 receptor α, β and γ chain expression for T cell growth

1996 • 33 citations

Ligand-induced autoregulation of IL-2 receptor α chain expression in murine T cell lines

1996 • 22 citations

Costimulatory Effect of IL-12 on the Activation of Naive, Memory CD4+T Cells, and Th1 Clone

1997 • 22 citations

Differential requirement of CD28 for IL-12 receptor expression and function in CD4+ and CD8+ T cells

2001 • 22 citations

CD28 costimulation is required not only to induce IL-12 receptor but also to render Janus kinases / STAT4 responsive to IL-12 stimulation in TCR-triggered T cells

2001 • 20 citations

IL-2 receptor alpha-chain expression is independently regulated in primary and secondary lymphoid organs.

1998 • 17 citations

B7‐1 synergizes with interleukin‐12 in interleukin‐2 receptor α expression by mouse T helper 1 clones

1996 • 16 citations

IL-2 Receptor α-Chain Expression Is Independently Regulated in Primary and Secondary Lymphoid Organs

1998 • 13 citations

Cloning and Chromosomal Assignment of the Porcine Interleukin-2 Receptor Alpha(IL-2R.ALPHA.) Gene.

2000 • 5 citations