Nitric oxide insufficiency and atherothrombosis

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1999 • 21,494 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

NAD(P)H Oxidase

2000 • 2,902 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

1986 • 2,422 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

1994 • 1,704 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

1998 • 1,475 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction

1998 • 1,182 citations

The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome

2016 • 1,052 citations

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

2002 • 970 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

1992 • 822 citations

Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine

1991 • 813 citations

T ⁻⁷⁸⁶ →C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm

1999 • 774 citations

Mechanisms of smooth muscle contraction

1996 • 748 citations

New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases

1999 • 717 citations

Superoxide Generation from Endothelial Nitric-oxide Synthase

1998 • 701 citations

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

1992 • 697 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Nitric oxide and its role in the cardiovascular system

1995 • 598 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 593 citations

Does ADMA Cause Endothelial Dysfunction?

2000 • 590 citations

Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level.

1994 • 590 citations

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

1997 • 585 citations

Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

2001 • 580 citations

Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action

2001 • 579 citations

Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease

2003 • 574 citations

The chemistry of DNA damage from nitric oxide and peroxynitrite

1999 • 547 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

1990 • 507 citations

Biochemical Evidence for Impaired Nitric Oxide Synthesis in Patients With Peripheral Arterial Occlusive Disease

1997 • 501 citations

cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

1996 • 473 citations

Endogenous Dimethylarginine as an Inhibitor of Nitric Oxide Synthesis

1992 • 471 citations

Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations

1997 • 470 citations

Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention

2003 • 456 citations

Inactivation of endothelial derived relaxing factor by oxidized lipoproteins.

1992 • 452 citations

M<scp>AMMALIAN</scp> S<scp>ELENIUM</scp>-C<scp>ONTAINING</scp> P<scp>ROTEINS</scp>

2001 • 449 citations

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

2000 • 448 citations

Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin.

1978 • 446 citations

DNA Damage Induced by Peroxynitrite: Subsequent Biological Effects

1997 • 433 citations

Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.

1996 • 413 citations

Superoxide Anion Production Is Increased in a Model of Genetic Hypertension

1999 • 413 citations

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

1997 • 411 citations

Concomitant S‐, N‐, and heme‐nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo

2002 • 397 citations

Nitric oxide released from activated platelets inhibits platelet recruitment.

1997 • 388 citations

Reduced Endothelial Nitric Oxide Synthase Expression and Production in Human Atherosclerosis

1998 • 386 citations

Biochemical mechanisms of platelet activation

1989 • 370 citations

Vitamin C Improves Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans With Hypercholesterolemia

1997 • 360 citations

Evidence of Association of the ecNOS Gene Polymorphism with Plasma NO Metabolite Levels in Humans

2000 • 355 citations

5-Methyltetrahydrofolate, the Active Form of Folic Acid, Restores Endothelial Function in Familial Hypercholesterolemia

1998 • 351 citations

Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals.

1994 • 349 citations

Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine.

1994 • 330 citations

Biochemical mechanisms of platelet activation

1989 • 328 citations

Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.

1992 • 324 citations

Endothelial Dysfunction Induced by Hyperhomocyst(e)inemia

2003 • 308 citations

Tetrahydrobiopterin and Dysfunction of Endothelial Nitric Oxide Synthase in Coronary Arteries

1995 • 295 citations

Mechanism of Nitric Oxide–Induced Vasodilatation

1999 • 291 citations

Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction

1999 • 290 citations

Nitric oxide in vascular biology

2003 • 271 citations

Role of Nitric Oxide

1998 • 269 citations

Endothelium-Dependent Dilatation Is Impaired in Young Healthy Subjects With a Family History of Premature Coronary Disease

1997 • 257 citations

Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide1

2002 • 257 citations

Platelet-Endothelium Interactions

1993 • 256 citations

Peroxynitrite-Dependent Tryptophan Nitration

1996 • 254 citations

Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production

1995 • 251 citations

The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide

2002 • 249 citations

Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells

1990 • 239 citations

Interaction of myeloperoxidase with peroxynitrite

1993 • 233 citations

Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase.

1987 • 233 citations

Pro-thrombotic State Induced by Post-translational Modification of Fibrinogen by Reactive Nitrogen Species

2004 • 222 citations

ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of ?-arginine and B vitamins

2002 • 216 citations

Tetrahydrobiopterin Improves Endothelial Function in Patients with Coronary Artery Disease

2000 • 211 citations

Deficient Platelet-Derived Nitric Oxide and Enhanced Hemostasis in Mice Lacking the NOSIII Gene

1999 • 211 citations

Chemical nature of nitric oxide storage forms in rat vascular tissue

2002 • 209 citations

Peroxynitrite: reactive, invasive and enigmatic

1999 • 209 citations

Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries.

1992 • 200 citations

Dietary Correction of Hypercholesterolemia in the Rabbit Normalizes Endothelial Superoxide Anion Production

1995 • 197 citations

Heterozygous Cellular Glutathione Peroxidase Deficiency in the Mouse

2002 • 193 citations

Concomitant presence of N-nitroso and S-nitroso proteins in human plasma

2002 • 193 citations

Expression of constitutive endothelial nitric oxide synthase in human blood platelets

1995 • 191 citations

Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine.

1990 • 190 citations

Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39.

1998 • 189 citations

Cellular glutathione peroxidase deficiency and endothelial dysfunction

2002 • 186 citations

Exposure to Shear Stress Alters Endothelial Adhesiveness

1995 • 181 citations

An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis.

1991 • 179 citations

Identification of constitutive and inducible forms of nitric oxide synthase in human platelets.

1995 • 178 citations

Plasma Nitrosothiols Contribute to the Systemic Vasodilator Effects of Intravenously Applied NO

2002 • 175 citations

Peroxynitrite Mediated Oxidation of Purine Bases of Nucleosides and Isolated DNA

1996 • 174 citations

Genetic Determinants of Arterial Thrombosis

2003 • 174 citations

Impaired Platelet Production of Nitric Oxide Predicts Presence of Acute Coronary Syndromes

1998 • 170 citations

Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis.

1996 • 164 citations

DNA damage by peroxynitrite characterized with DNA repair enzymes

1996 • 159 citations

The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study

2003 • 158 citations

The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients

2003 • 155 citations

Nitric oxide synthase inhibitors and hypertension in children and adolescents

1997 • 153 citations

Identification of the NO Synthase isoforms Expressed in Human Neutrophil Granulocytes, Megakaryocytes and Platelets

1997 • 153 citations

Nitric Oxide and the Cardiovascular System

1994 • 152 citations

Regression of Atherosclerosis

1999 • 152 citations

Nitric Oxide Activity in the Atherosclerotic Human Coronary Circulation

1997 • 151 citations

Association of Asymmetric Dimethylarginine and Endothelial Dysfunction

2003 • 150 citations

Microvascular Responses to Inhibition of Nitric Oxide Production

1995 • 148 citations

Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries.

1991 • 146 citations

Endothelial Nitric Oxide Synthase-Dependent Cerebral Blood Flow Augmentation by <scp>L</scp>-Arginine After Chronic Statin Treatment

2000 • 143 citations

Oral l-arginine improves endothelial dysfunction in patients with essential hypertension

2002 • 139 citations

Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets

1986 • 136 citations

Nitric Oxide Inhibits Capacitative Cation Influx in Human Platelets by Promoting Sarcoplasmic/Endoplasmic Reticulum Ca ²⁺ -ATPase–Dependent Refilling of Ca ²⁺ Stores

1999 • 134 citations

Inactivation of Glutathione Peroxidase by Peroxynitrite

1998 • 133 citations

Effect of inhibition of nitric oxide synthase on dynamic cerebral autoregulation in humans

2000 • 124 citations

Oxidative stress promotes blood cell-endothelial cell interactions in the microcirculation

2002 • 122 citations

Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA

2003 • 115 citations

Acute Intravenous <scp>l</scp> -Arginine Infusion Decreases Endothelin-1 Levels and Improves Endothelial Function in Patients With Angina Pectoris and Normal Coronary Arteriograms

2003 • 107 citations

Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol

2002 • 106 citations

Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxide

2001 • 103 citations

Isolation of nitric oxide synthase from human platelets

1994 • 99 citations

Inhibition of Nitric Oxide Biosynthesis Promotes P-selectin Expression in Platelets

1995 • 98 citations

Effects of nitric oxide/EDRF on platelet surface glycoproteins

1996 • 98 citations

Nitric oxide and its relationship to thrombotic disorders

2003 • 97 citations

Inducible nitric oxide synthase (iNOS) and regulation of leucocyte/endothelial cell interactions: studies in iNOS‐deficient mice

2001 • 91 citations

Epicardial vasomotor responses to acetylcholine are not predicted by coronary atherosclerosis as assessed by intracoronary ultrasound

1995 • 87 citations

l-Arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion

1995 • 86 citations

Increased superoxide anion production in humans: a possible mechanism for the pathogenesis of hypertension.

1996 • 86 citations

Endothelial nitric oxide synthase polymorphisms and hypertension

2003 • 81 citations

Vascular endothelial dysfunction resulting from l-arginine deficiency in a patient with lysinuric protein intolerance

2001 • 81 citations

Plasma Glutathione Peroxidase Deficiency and Platelet Insensitivity to Nitric Oxide in Children With Familial Stroke

1999 • 81 citations

Vascular endothelial dysfunction resulting from l-arginine deficiency in a patient with lysinuric protein intolerance

2001 • 79 citations

Nitric oxide release from resting human platelets

1995 • 78 citations

Endothelial dysfunction in hypercholesterolemia is improved by l-arginine administration: possible role of oxidative stress

2002 • 73 citations

Nitric Oxide Inhalation Inhibits Platelet Aggregation and Platelet-Mediated Pulmonary Thrombosis in Rats

1997 • 70 citations

The endothelial nitric oxide synthase (Glu298Asp and –786T&gt;C) gene polymorphisms are associated with coronary in-stent restenosis

2002 • 67 citations

Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30-39 years.

1984 • 62 citations

The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm

2003 • 56 citations

Role of adhesion molecules in vascular regulation and damage

2000 • 55 citations

Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina

1996 • 54 citations

Constitutive and inducible nitric oxide synthases in human megakaryoblastic cells.

1992 • 53 citations

Inhibition of platelet recruitment by endothelial cell CD39/ecto-ADPase: significance for occlusive vascular diseases.

2001 • 51 citations

Modulation of Inducible Nitric Oxide Synthase mRNA Stability by Tetrahydrobiopterin in Vascular Smooth Muscle Cells

1998 • 45 citations

Gene transfer of nitric oxide synthase

1999 • 45 citations

Oxidized LDL and expression of monocyte adhesion molecules

1999 • 44 citations

L-Arginine protects from ischemia-reperfusion-induced endothelial dysfunction in humans in vivo

2003 • 39 citations

The Effect of Nitric Oxide Synthase Inhibition on Acute Platelet Accumulation and Hemodynamic Depression in a Rat Model of Thromboembolic Stroke

1997 • 39 citations

The Glu298Asp polymorphism in endothelial nitric oxide synthase gene is associated with coronary in-stent restenosis

2002 • 37 citations

Nitric Oxide and Renal Autoregulation

1997 • 32 citations

Nitric Oxide in Atherosclerosis

2002 • 27 citations

Different roles for nitrogen monoxide and peroxynitrite in lipid peroxidation induced by activated neutrophils

2000 • 25 citations

Lipid peroxidation and cell death mechanisms in pulmonary epithelial cells induced by peroxynitrite and nitric oxide

2002 • 25 citations

Nitric oxide and peroxynitrite in lipid peroxidation.

1998 • 20 citations

Protective effect of L-arginine on liver ischemia-reperfusion injury

1997 • 16 citations

<scp>l</scp>-Arginine-Induced Regional Cerebral Blood Flow Increase is Abolished after Transient Focal Cerebral Ischemia in the Rat

1997 • 14 citations

Cell and molecular biology of nitric oxide synthases.

2000 • 9 citations

The Biological Chemistry of Nitric Oxide

2003 • 9 citations

L-Arginine: Its Role in Cardiovascular Therapy

2003 • 7 citations

Cell and Molecular Biology of Nitric Oxide Synthases

2003 • 6 citations

Nitric Oxide and Platelet-Mediated Hemostasis

2000 • 6 citations

Nitric Oxide in Atherosclerosis

2003 • 5 citations

Nitric Oxide and Platelet-Mediated Hemostasis

2003 • 3 citations