Nitric Oxide and Platelet-Mediated Hemostasis

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Hematology: Basic Principles and Practice

1991 • 1,907 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene.

1995 • 783 citations

The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium

1987 • 765 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators

1981 • 629 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

1992 • 527 citations

Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

1990 • 507 citations

cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

1996 • 473 citations

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

1997 • 411 citations

Nitric oxide released from activated platelets inhibits platelet recruitment.

1997 • 388 citations

Molecular Defects in Interactions of Platelets with the Vessel Wall

1984 • 381 citations

Biochemical mechanisms of platelet activation

1989 • 370 citations

Paradoxical fate and biological action of peroxynitrite on human platelets.

1994 • 364 citations

Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP.

1990 • 354 citations

Progress in Hemostasis and Thrombosis.

1974 • 349 citations

Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions.

1992 • 339 citations

Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease.

1993 • 339 citations

Elevatedl-Arginine/Dimethylarginine Ratio Contributes to Enhanced Systemic NO Production by Dietaryl-Arginine in Hypercholesterolemic Rabbits

1996 • 308 citations

Cytoadhesins, Integrins, and Platelets

1988 • 306 citations

Thrombosis and Hemorrhage

2002 • 294 citations

NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

1993 • 294 citations

Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis

1993 • 279 citations

EIGHTH GADDUM MEMORIAL LECTURE UNIVERSITY OF LONDON INSTITUTE OF EDUCATION DECEMBER 1980: BIOLOGICAL IMPORTANCE OF PROSTACYCLIN

1982 • 276 citations

Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange. Comparison of heme-containing and heme-deficient enzyme forms.

1986 • 272 citations

Biosynthesis of endothelium-derived relaxing factor: A cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase

1989 • 271 citations

Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase

1998 • 260 citations

N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.

1989 • 245 citations

Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide.

1995 • 229 citations

Molecular Events that Control the Protein C Anticoagulant Pathway

1993 • 223 citations

Deficient Platelet-Derived Nitric Oxide and Enhanced Hemostasis in Mice Lacking the NOSIII Gene

1999 • 211 citations

Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries.

1992 • 200 citations

Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils

1991 • 195 citations

Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.

1992 • 175 citations

Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis.

1996 • 164 citations

Tissue plasminogen activator promotes platelet disaggregation in plasma.

1987 • 162 citations

gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors.

1982 • 156 citations

Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor.

1993 • 153 citations

Inhaled Nitric Oxide Inhibits Human Platelet Aggregation, P-Selectin Expression, and Fibrinogen Binding In Vitro and In Vivo

1998 • 153 citations

Identification of the NO Synthase isoforms Expressed in Human Neutrophil Granulocytes, Megakaryocytes and Platelets

1997 • 153 citations

PLATELET MORPHOLOGY**Supported by grants from the USPHS # HE-11880, AI-05153, and CA-08832, Cardiovascular Clinical Research Program Project, and the Life Insurance Medical Research Fund.

1971 • 148 citations

Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols.

1995 • 148 citations

Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries.

1991 • 146 citations

The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit

1991 • 136 citations

Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets

1986 • 136 citations

Expression of Inducible Nitric Oxide Synthase Inhibits Platelet Adhesion and Restores Blood Flow in the Injured Artery

1996 • 128 citations

Evidence for a theory of physical fragmentation of megakaryocytes, implying that all platelets are produced in the pulmonary circulation

1982 • 120 citations

Role of endothelium-derived nitric oxide in the bleeding tendency of uremia.

1990 • 120 citations

Overexpression of Human Endothelial Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells and in Balloon-Injured Carotid Artery

1998 • 108 citations

Plasma Levels of Nitrite/Nitrate and Platelet cGMP Levels Are Decreased in Patients With Atrial Fibrillation

1997 • 102 citations

Isolation of nitric oxide synthase from human platelets

1994 • 99 citations

Nitric Oxide Inhibits Thrombin Receptor-activating Peptide-induced Phosphoinositide 3-Kinase Activity in Human Platelets

1999 • 98 citations

EDRF increases cyclic GMP in platelets during passage through the coronary vascular bed.

1989 • 98 citations

Inhibition of Nitric Oxide Biosynthesis Promotes P-selectin Expression in Platelets

1995 • 98 citations

Further Evidence of the Presence of Constitutive and Inducible Nitric Oxide Synthase Isoforms in Human Platelets

1996 • 98 citations

Effects of nitric oxide/EDRF on platelet surface glycoproteins

1996 • 98 citations

Role of a copper (I)‐dependent enzyme in the anti‐platelet action of S‐nitrosoglutathione

1996 • 88 citations

Nitric oxide release from resting human platelets

1995 • 78 citations

Endothelium-derived relaxing factor modulates platelet aggregation in an in vivo model of recurrent platelet activation.

1992 • 73 citations

Nitric Oxide Inhalation Inhibits Platelet Aggregation and Platelet-Mediated Pulmonary Thrombosis in Rats

1997 • 70 citations

Inhaled Nitric Oxide Increases Coronary Artery Patency After Thrombolysis

1996 • 70 citations

Effect of Nitric Oxide Synthase Inhibition on Bleeding Time in Humans

1995 • 69 citations

Prostaglandins and thromboxanes: "middlemen" modulating platelet function in hemostasis and thrombosis.

1978 • 66 citations

Nitroprusside differentially inhibits ADP-stimulated calcium influx and mobilization in human platelets

1989 • 65 citations

Cyclic GMP increases the rate of the calcium extrusion pump in intact human platelets but has no direct effect on the dense tubular calcium accumulation system

1992 • 55 citations

Agents that modify EDRF formation alter antiplatelet properties of brain arteriolar endothelium in vivo

1991 • 53 citations

Mechanisms of platelet activation

2001 • 53 citations

Constitutive and inducible nitric oxide synthases in human megakaryoblastic cells.

1992 • 53 citations

Hematology: Basic Principles and Practice, 2nd ed

1995 • 52 citations

Evidence for altered platelet nitric oxide synthesis in essential hypertension

1993 • 51 citations

Vascular Medicine: A Textbook of Vascular Biology and Diseases

1992 • 50 citations

Nitric Oxide Modulates the Activity of the Hemoproteins Prostaglandin I2Synthase and Thromboxane A2Synthase

1997 • 42 citations

Interactions Between Nitric Oxide and Prostacyclin

1993 • 39 citations

Inhibitory effect of 8-bromo cyclic GMP on an extracellular Ca2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets

1989 • 38 citations

Potentiation of endogenous nitric oxide with superoxide dismutase inhibits platelet-mediated thrombosis in injured and stenotic arteries

1995 • 35 citations

Nitric oxide synthase inhibition and platelet function

1994 • 33 citations

Cellular mechanisms of atherogenesis and the effects of nitric oxide

1992 • 32 citations

Identification of a Specific Transport System for L-Arginine in Human Platelets

1995 • 29 citations

Thrombin induced platelet adhesion to endothelium is modified by endothelial derived relaxing factor (EDRF)

1989 • 29 citations

NG-monomethyl-l-arginine increases platelet deposition on damaged endothelium in vivo. A scanning electron microscopic study

1991 • 29 citations

Nitric Oxide Inhibits ATP-Dependent CA2+Uptake into Platelet Membrane Vesicles

1996 • 26 citations

Influence of authentic nitric oxide on basal cytosolic [Ca²⁺] and Ca²⁺ release from internal stores in human platelets

1996 • 22 citations

Antithrombotics : pathophysiological rationale for pharmacological interventions

1991 • 22 citations

Inhibition of Collagen- and ADP-Induced Platelet Aggregation by Substance P In Vivo

1990 • 20 citations

Ultrastructure of the platelet release reaction in response to various aggregating agents and their inhibitors.

1973 • 19 citations

Impaired NO release from bovine aortic endothelial cells exposed to activated platelets

1997 • 13 citations

Nitric Oxide Stimulates the Phosphorylation of rap1b in Human Platelets and Acts Synergistically with Iloprost

1996 • 13 citations

NITRIC OXIDE

1996 • 9 citations

Nitric oxide complements prostacyclin in the regulation of endothelial thromboresistance under flow conditions.

1993 • 5 citations

Role of Nitric Oxide in Endothelial Cell - Platelet Interactions

1991 • 4 citations

Antithrombotics and the Lipoxygenase Pathway

1991 • 4 citations