Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

2002 • 1,352 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

Unraveling peroxynitrite formation in biological systems

2001 • 720 citations

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

1995 • 707 citations

Serine/Threonine Protein Kinases and Apoptosis

2000 • 692 citations

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

2000 • 674 citations

Nitric oxide synthase activity in mitochondria

1997 • 576 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

1995 • 460 citations

Effects of peroxynitrite‐induced protein modifications on tyrosine phosphorylation and degradation

1996 • 450 citations

Intracellular ATP, a switch in the decision between apoptosis and necrosis

1998 • 353 citations

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

1996 • 341 citations

Melatonin is a scavenger of peroxynitrite

1997 • 320 citations

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

1996 • 320 citations

Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology

1998 • 259 citations

The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

2001 • 241 citations

Protective effect of melatonin in carrageenan‐induced models of local inflammation: Relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity

1997 • 238 citations

Cytokine-Mediated Apoptosis in Cardiac Myocytes

1999 • 223 citations

Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger

1996 • 220 citations

Peroxynitrite Is an Essential Component of Cytokines Production Mechanism in Human Monocytes through Modulation of Nuclear Factor-κB DNA Binding Activity

2002 • 219 citations

Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death.

1998 • 218 citations

Catalysis by nitric oxide synthase

1998 • 211 citations

Nuclear factor-κB, cancer, and apoptosis

2000 • 210 citations

Peroxynitrite‐induced thymocyte apoptosis: the role of caspases and poly (ADP‐ribose) synthetase (PARS) activation

1998 • 210 citations

Poly(ADP-Ribose) Synthetase Activation Mediates Mitochondrial Injury During Oxidant-Induced Cell Death

1998 • 204 citations

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

2001 • 203 citations

Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis

1999 • 194 citations

Nitric Oxide Is Generated on the Skin Surface by Reduction of Sweat Nitrate

1996 • 176 citations

The Reaction of Ebselen with Peroxynitrite

1996 • 171 citations

Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure

2001 • 164 citations

Catalytic Scavenging of Peroxynitrite by Isomeric Mn(III) N-Methylpyridylporphyrins in the Presence of Reductants

1999 • 158 citations

Peroxynitrite Causes Apoptosis in Rat Thymocytes

1995 • 153 citations

Apoptosis and nuclear factor-κb: a tale of association and dissociation

2000 • 146 citations

Energy Requirement for Caspase Activation and Neuronal Cell Death

2000 • 130 citations

Purines inhibit poly(ADP‐ribose) polymerase activation and modulate oxidant‐induced cell death

2001 • 127 citations

Tricarboxylic Acid Cycle Substrates Prevent PARP-Mediated Death of Neurons and Astrocytes

2002 • 127 citations

Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts

2000 • 120 citations

Peroxynitrite scavenging activity of herb extracts

2002 • 119 citations

Selenium-Containing Compounds Protect DNA fromSingle-Strand Breaks Caused by Peroxynitrite

1996 • 117 citations

Superoxide attenuates macrophage apoptosis by NF-kappa B and AP-1 activation that promotes cyclooxygenase-2 expression.

1999 • 110 citations

Elevation of brain glutathione by γ‐glutamylcysteine ethyl ester protects against peroxynitrite‐induced oxidative stress

2002 • 108 citations

Poly(ADP-ribose) Polymerase Mediates the Suicide Response to Massive DNA Damage: Studies in Normal and DNA-repair Defective Cells

2020 • 106 citations

Nitrotyrosine Causes Selective Vascular Endothelial Dysfunction and DNA Damage

2000 • 104 citations

Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of poly(ADP-ribose) polymerase

1986 • 103 citations

Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells

2002 • 102 citations

Nitrosative Stress-induced Apoptosis through Inhibition of NF-κB

2002 • 101 citations

ATP Controls Neuronal Apoptosis Triggered by Microtubule Breakdown or Potassium Deprivation

1999 • 96 citations

Peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease

1998 • 96 citations

Mechanisms of Peroxynitrite Decomposition Catalyzed by FeTMPS, a Bioactive Sulfonated Iron Porphyrin

2001 • 92 citations

Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and phosphatidylinositol 3-kinase (PI3 kinase)

2001 • 88 citations

Effect of <scp>L</scp>‐buthionine‐(S,R)‐sulphoximine, an inhibitor of γ‐glutamylcysteine synthetase on peroxynitrite‐ and endotoxic shock‐induced vascular failure

1998 • 87 citations

Superoxide Attenuates Macrophage Apoptosis by NF-κB and AP-1 Activation That Promotes Cyclooxygenase-2 Expression

1999 • 87 citations

Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells

2000 • 86 citations

Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation

1998 • 79 citations

Enhancement of Glutathione Cardioprotection by Ascorbic Acid in Myocardial Reperfusion Injury

2002 • 79 citations

The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death

2000 • 77 citations

Insulin Secretion, DNA Damage, and Apoptosis in Human and Rat Islets of Langerhans Following Exposure to Nitric Oxide, Peroxynitrite, and Cytokines

1998 • 75 citations

Nerve Growth Factor Protects PC12 Cells Against Peroxynitrite‐Induced Apoptosis via a Mechanism Dependent on Phosphatidylinositol 3‐Kinase

1997 • 75 citations

Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity.

1999 • 74 citations

Free 3-Nitrotyrosine Causes Striatal NeurodegenerationIn Vivo

2001 • 71 citations

Peroxynitrite Production, DNA Breakage, and Poly(ADP-ribose) Polymerase Activation in a Mouse Model of Oxazolone-Induced Contact Hypersensitivity

2001 • 70 citations

Genotoxicity, Mitochondrial Damage, and Apoptosis in Human Lymphoblastoid Cells Exposed to Peroxynitrite Generated from SIN-1

2002 • 55 citations

Contrasting effects of NO and peroxynitrites on HSP70 expression and apoptosis in human monocytes

2000 • 44 citations

Phosphorylation-Based Signaling in Fas Receptor-Mediated Apoptosis

2000 • 41 citations

Enhancement of Peroxynitrite-Induced Apoptosis in PC12 Cells by Fibroblast Growth Factor-1 and Nerve Growth Factor Requires p21Ras Activation and Is Suppressed by Bcl-2

1998 • 38 citations

Inhibition of poly(ADP‐ribose) synthetase (PARS) and protection against peroxynitrite‐induced cytotoxicity by zinc chelation

1999 • 36 citations

Essential Role of the Mitochondrial Respiratory Chain in Peroxynitrite‐Induced Strand Scission of Genomic DNA

2000 • 36 citations

BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death

2000 • 36 citations

Insulin‐like growth factor‐1 protects peroxynitrite‐induced cell death by preventing cytochromec‐induced caspase‐3 activation

2002 • 33 citations

NF-κB Inhibition Enhances Peroxynitrite-Induced Enterocyte Apoptosis

2002 • 33 citations

Peroxynitrite modulates MnSOD gene expression in lung epithelial cells

1998 • 33 citations

Cytotoxicity of Peroxynitrite in Rat Pancreatic Acinar AR4–2J Cells

1997 • 29 citations

Peroxynitrite‐mediated release of arachidonic acid from PC12 cells

2000 • 27 citations

3-Morpholinosydnonimine Hydrochloride Induces p53-Dependent Apoptosis in Murine Primary Neural Cells: A Critical Role for p21ras–MAPK–p19ARF Pathway

2002 • 25 citations

Pre-exposure to heat shock inhibits peroxynitrite-induced activation of poly(ADP) ribosyltransferase and protects against peroxynitrite cytotoxicity in J774 macrophages

1996 • 22 citations

Acidic Fibroblast Growth Factor Attenuates the Cytotoxic Effects of Peroxynitrite in Primary Human Osteoblast Precursors

2001 • 21 citations

Mimosine prevents the death of glucose‐deprived immunostimulated astrocytes by scavenging peroxynitrite

2002 • 16 citations

Involvement of mitogen-activated protein kinase in peroxynitrite-induced cell death of human neuroblastoma SH-SY5Y cells

2000 • 15 citations

Polyphenols in Red Wines Prevent NADH Oxidation Induced by Peroxynitrite

2002 • 11 citations

Calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA in U937 cells exposed totert-butylhydroperoxide: The role of arachidonic acid

2000 • 11 citations

Phosphatidylinositol 3-kinase, Phosphoinositides and Apoptosis

2006 • 3 citations