Inhibition of Nitric Oxide Biosynthesis Promotes P-selectin Expression in Platelets

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Rapid neutrophil adhesion to activated endothelium mediated by GMP-140

1990 • 997 citations

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

1989 • 993 citations

Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.

1975 • 932 citations

PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes

1989 • 878 citations

Selectins.

1993 • 869 citations

Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets

1992 • 800 citations

Endothelial cell interactions with granulocytes: tethering and signaling molecules

1992 • 773 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils.

1991 • 600 citations

GMP-140 mediates adhesion of stimulated platelets to neutrophils

1990 • 515 citations

Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

1993 • 490 citations

Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat.

1990 • 471 citations

C5a-induced expression of P-selectin in endothelial cells.

1994 • 470 citations

In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

1993 • 452 citations

Complement Proteins C5b-9 Induce Secretion of High Molecular Weight Multimers of Endothelial von Willebrand Factor and Translocation of Granule Membrane Protein GMP-140 to the Cell Surface

1989 • 442 citations

Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140).

1992 • 385 citations

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

1983 • 368 citations

Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine.

1994 • 330 citations

Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding.

1993 • 302 citations

Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation

1994 • 283 citations

Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta.

1986 • 282 citations

GMP‐140: A receptor for neutrophils and monocytes on activated platelets and endothelium

1991 • 212 citations

cGMP and Nitric Oxide Modulate Thrombin-Induced Endothelial Permeability

1995 • 201 citations

Requirements for leukocyte adhesion molecules in nephrotoxic nephritis.

1993 • 197 citations

Inhibition of Endothelial Nitric Oxide Synthase Activity by Protein Kinase C

1995 • 188 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer.

1993 • 177 citations

Properties of GMP-140, an inducible granule membrane protein of platelets and endothelium.

1990 • 171 citations

Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.

1987 • 156 citations

Inhibitory action of guanosine 3′,5′-monophosphate on thrombin-induced phosphatidylinositol turnover and protein phosphorylation in human platelets

1981 • 140 citations

The signal transduction induced by thrombin in human platelets

1990 • 78 citations

A method for isolation and fluorescent labeling of rat neutrophils for intravital microvascular studies

1990 • 69 citations

Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation.

1991 • 66 citations

Polymorphonuclear leukocyte-induced vasocontraction and endothelial dysfunction. Role of selectins.

1994 • 65 citations

A phorbol ester inhibits the release of endothelium-derived relaxing factor

1987 • 63 citations

Demonstration of Depressed Polymorphonuclear Leukocyte Function in Nonviremic FeLV-Infected Cats

1986 • 46 citations

GMP-140 mediates adhesion of stimulated platelets to neutrophils

1990 • 44 citations

Nitric oxide modulates signaling between cultured adult peripheral cardiac neurons and cardiomyocytes

1995 • 41 citations

Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine

1991 • 36 citations

Expression of Adhesion Molecules on the Surface of Activated Platelets is Diminished by PGI₂-analogues and an NO (EDRF)-Donor: A Comparison Between Platelets of Healthy and Diabetic Subjects

1994 • 24 citations

Myocardial and endothelial protection by TMS in ischemia-reperfusion injury

1995 • 23 citations

Protein Kinase Assay Using Tritiated Peptide Substrates and Ferric Adsorbent Paper for Phosphopeptide Binding

1993 • 15 citations