5-Methyltetrahydrofolate, the Active Form of Folic Acid, Restores Endothelial Function in Familial Hypercholesterolemia

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1987 • 1,072 citations

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

1997 • 585 citations

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion

1995 • 479 citations

Measuring Forearm Blood Flow and Interpreting the Responses to Drugs and Mediators

1995 • 402 citations

Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication

1995 • 401 citations

Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.

1996 • 375 citations

Vitamin C Improves Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans With Hypercholesterolemia

1997 • 360 citations

Thermolabile variant of 5, 10-methylenetetrahydrofolate reductaseassociated with low red-cell folates: implications for folate intake recommendations

1997 • 346 citations

Tetrahydrobiopterin and Dysfunction of Endothelial Nitric Oxide Synthase in Coronary Arteries

1995 • 295 citations

Tetrahydrobiopterin Regulates Superoxide and Nitric Oxide Generation by Recombinant Endothelial Nitric Oxide Synthase

1997 • 281 citations

Xanthine Oxidase Inhibition With Oxypurinol Improves Endothelial Vasodilator Function in Hypercholesterolemic but Not in Hypertensive Patients

1997 • 247 citations

Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease

1995 • 227 citations

Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: Implications for impaired vasomotion

1995 • 170 citations

In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide

1995 • 129 citations

Low Whole-Blood S -Adenosylmethionine and Correlation Between 5-Methyltetrahydrofolate and Homocysteine in Coronary Artery Disease

1996 • 103 citations

Granulocyte Function in Women With Diabetes and Asymptomatic Bacteriuria

1997 • 87 citations

Some metabolic relationships between biopterin and folate: Implications for the ?methyl trap hypothesis?

1991 • 80 citations

Characterization of the dihydropterin reductase activity of pig liver methylenetetrahydrofolate reductase.

1980 • 73 citations

Vitamins C, E and A and Heme Oxygenase in Rats Fed Methyl/Folate-Deficient Diets11This work was supported by NIH grant CA42710-10 and Westreco Inc., Van Nuys, CA.

1997 • 49 citations

Reduction of Quinonoid Dihydrobiopterin to Tetrahydrobiopterin by Nitric Oxide Synthase

1996 • 37 citations

The effect of folic acid on the homocysteine metabolism in human umbilical vein endothelial cells (HUVECs)

1996 • 35 citations

No Functional Involvement of 5-Hydroxytryptamine1A Receptors in Nitric Oxide-Dependent Dilatation Caused by Serotonin in the Human Forearm Vascular Bed

1994 • 22 citations

[6] Endothelial nitric oxide synthase expression in heterologous systems

1996 • 5 citations