Endothelial nitric oxide synthase polymorphisms and hypertension

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

Molecular Mechanisms of Human Hypertension

2001 • 1,672 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction

1998 • 1,182 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Serial study of factors influencing changes in cardiac output during human pregnancy

1989 • 808 citations

T ⁻⁷⁸⁶ →C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm

1999 • 774 citations

The power of words.

1951 • 744 citations

NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease

1997 • 719 citations

Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice

2001 • 609 citations

Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension

1998 • 530 citations

Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298

2000 • 527 citations

A Common Variant of the Endothelial Nitric Oxide Synthase (Glu ²⁹⁸ →Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK

1999 • 520 citations

Endogenous Dimethylarginine as an Inhibitor of Nitric Oxide Synthesis

1992 • 471 citations

Aging Progressively Impairs Endothelium-Dependent Vasodilation in Forearm Resistance Vessels of Humans

1996 • 471 citations

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

2000 • 448 citations

The role of nitric oxide in the pathogenesis of preeclampsia

1994 • 392 citations

Basal nitric oxide synthesis in essential hypertension

1997 • 374 citations

Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction

1998 • 361 citations

Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats.

1998 • 350 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.

1992 • 343 citations

Defective <scp>l</scp> -Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients

1996 • 312 citations

Role of Superoxide in the Depressed Nitric Oxide Production by the Endothelium of Genetically Hypertensive Rats

1995 • 304 citations

Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction

1999 • 290 citations

Preserved Endothelium-Dependent Vasodilatation in Patients with Essential Hypertension

1994 • 287 citations

Inhibition of nitric oxide synthesis increases blood pressure in healthy humans

1993 • 278 citations

Effect of antihypertensive treatment on endothelium-dependent vascular relaxation in patients with essential hypertension

1993 • 246 citations

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension

1992 • 238 citations

Nitric oxide-mediated vasodilation in human pregnancy

1997 • 205 citations

Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism

2000 • 194 citations

Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.

1993 • 192 citations

Effect of captopril and enalapril on endothelial function in hypertensive patients.

1994 • 186 citations

G894T Polymorphism in the Endothelial Nitric Oxide Synthase Gene Is Associated With an Enhanced Vascular Responsiveness to Phenylephrine

1999 • 183 citations

Glu298Asp Endothelial Nitric Oxide Synthase Gene Polymorphism Interacts With Environmental and Dietary Factors to Influence Endothelial Function

2002 • 183 citations

Nitric oxide synthase gene polymorphisms, blood pressure and aortic stiffness in normotensive and hypertensive subjects

1998 • 180 citations

Modifier effect of ENOS in autosomal dominant polycystic kidney disease

2002 • 175 citations

Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension

1995 • 160 citations

Endothelial Nitric Oxide Synthase Exon 7 Polymorphism, Ischemic Cerebrovascular Disease, and Carotid Atheroma

1998 • 150 citations

Lack of Evidence for Association Between the Endothelial Nitric Oxide Synthase Gene and Hypertension

1999 • 143 citations

Polymorphisms in endothelial nitric oxide synthase and atherogenesis

2001 • 139 citations

Evidence for a Familial Pregnancy-Induced Hypertension Locus in the eNOS-Gene Region

1997 • 139 citations

Selective Defect in Nitric Oxide Synthesis May Explain the Impaired Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1998 • 138 citations

Association of a Polymorphism of the Endothelial Constitutive Nitric Oxide Synthase Gene With Myocardial Infarction in the Japanese Population

1998 • 135 citations

Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease

2001 • 124 citations

Association of the Glu298Asp Polymorphism in the Endothelial Nitric Oxide Synthase Gene with Essential Hypertension Resistant to Conventional Therapy

2001 • 114 citations

Positive association of endothelial nitric oxide synthase gene polymorphism with hypertension in Northern Japan

2000 • 112 citations

Blockade of pressure natriuresis induced by inhibition of renal synthesis of nitric oxide in dogs

1992 • 110 citations

Association of the Missense Glu298Asp Variant of the Endothelial Nitric Oxide Syntahse Gene With Severe Preeclampsia

2000 • 108 citations

Endothelial Nitric Oxide Synthase Gene Polymorphism and Maternal Vascular Adaptation to Pregnancy

2001 • 98 citations

The effect of antihypertensive therapy on responsiveness to local intra-arterial NG-monomethyl-L-arginine in patients with essential hypertension

1994 • 90 citations

NOS3 Glu298Asp Genotype and Blood Pressure Response to Endurance Training

2000 • 90 citations

Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population‐based cohort

2002 • 89 citations

Mediatory Role of Endothelium-Derived Nitric Oxide in Renal Vasodilatory and Excretory Effects of Bradykinin

1991 • 82 citations

Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study

2001 • 77 citations

The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro

1993 • 75 citations

Differential inhibition by N^G‐monomethyl‐<scp>l</scp>‐arginine of vasodilator effects of acetylcholine and methacholine in human forearm vasculature

1993 • 64 citations

Physiological role of nitric oxide in regulation of renal function in humans

1997 • 63 citations

The biological significance of nitric oxide formation from <scp>l</scp>-arginine

1989 • 62 citations

Guanosine 3',5'-cyclic monophosphate as a mediator of inhibition of renin release

1988 • 61 citations

eNOS 894T allele and coronary blood flow at rest and during adenosine-induced hyperemia

2001 • 58 citations

Combined effects of endothelial nitric oxide synthase gene polymorphism (G894T) and insulin resistance status on blood pressure and familial risk of hypertension in young adults: the Bogalusa Heart Study

2001 • 50 citations

Genetic susceptibility to pre-eclampsia and chromosome 7q36

1999 • 49 citations

Lack of Association between T-786.RAR.C Mutation in the 5'-Flanking Region of the Endothelial Nitric Oxide Synthase Gene and Essential Hypertension.

2000 • 46 citations

Forearm blood flow responses to a nitric oxide synthase inhibitor in patients with treated essential hypertension

1994 • 38 citations

Lack of linkage between the endothelial nitric oxide synthase gene and hypertension.

1996 • 36 citations

Heredity and blood pressure.

1989 • 34 citations

VASCULAR ENDOTHELIUM IN HUMAN PHYSIOLOGY AND PATHOPHYSIOLOGY

2001 • 15 citations

Exploring vascular nitric oxide in health and disease. The Goulstonian Lecture 1996.

1997 • 10 citations