Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Vinculin, an intracellular protein localized at specialized sites where microfilament bundles terminate at cell membranes.

1980 • 502 citations

Microtubule Organizing Centers

1985 • 412 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound.

1982 • 403 citations

The Directed Migration of Eukaryotic Cells

1986 • 312 citations

Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets.

1983 • 294 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

CD4+ T Cells: Specificity and Function

1988 • 281 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

Mechanism of Specific Tumor-Cell Lysis by Alloimmune T Lymphocytes: Resolution and Characterization of Discrete Steps in the Cellular Interaction

1977 • 258 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

The specific direct interaction of helper T cells and antigen-presenting B cells.

1986 • 246 citations

Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes.

1988 • 230 citations

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells.

1987 • 194 citations

Membrane insertion at the leading edge of motile fibroblasts.

1983 • 192 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells.

1987 • 177 citations

Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.

1986 • 166 citations

Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.

1987 • 140 citations

Modulation of CD4 by antigenic activation.

1987 • 138 citations

Ultrastructure of human natural killer cells: nature of the cytolytic contacts in relation to cellular secretion.

1982 • 132 citations

Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes.

1987 • 128 citations

On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell.

1986 • 122 citations

Stimulation of fluorescence in a small contact region between rat basophil leukemia cells and planar lipid membrane targets by coherent evanescent radiation.

1982 • 119 citations

Polarization of NK cell cytoskeleton upon conjugation with sensitive target cells.

1983 • 97 citations

CD4 molecules are associated with the antigen receptor complex on activated but not resting T cells.

1988 • 95 citations

Perforin‐Dependent and ‐Independent Pathways of Cytotoxicity Mediated by Lymphocytes

1988 • 86 citations

The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized.

1988 • 86 citations

Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes.

1987 • 70 citations

A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus

1987 • 68 citations

An integral glycoprotein associated with the membrane attachment sites of actin microfilaments.

1985 • 63 citations

Studies of the mechanism of lymphocyte-mediated cytolysis. VII. Two stages in the T cell-mediated lytic cycle with distinct cation requirements.

1976 • 63 citations

Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells

1978 • 60 citations

Interaction and Activation of Antigen‐Specific T and B Cells

1987 • 59 citations

Studies on the mechanism of T cell-mediated lysis at the single effector cell level. I. Kinetic analysis of lethal hits and target cell lysis in multicellular conjugates.

1979 • 54 citations

The role of Ca2+ in activation of mature cytotoxic T lymphocytes for lysis.

1987 • 49 citations

Demonstration of a calcium influx in cytolytic T lymphocytes in response to target cell binding.

1987 • 48 citations

T-cell antigen receptors with identical variable regions but different diversity and joining region gene segments have distinct specificities but cross-reactive idiotypes.

1987 • 44 citations

The most efficient cytotoxic T lymphocytes are the least susceptible to lysis.

1987 • 41 citations

The Fluid Mosaic Model of Membrane Structure: Some Applications to Ligand-Receptor and Cell-Cell Interactions

1976 • 32 citations

A 200‐kd protein isolated from the fascia adherens membrane domains of chicken cardiac muscle cells is detected immunologically in fibroblast focal adhesions

1983 • 29 citations

Deleted Work

1955 • 0 citations