Cutting Edge: T Lymphocyte Activation by Repeated Immunological Synapse Formation and Intermittent Signaling

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

2002 • 1,177 citations

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

2002 • 707 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.

1995 • 528 citations

Two-photon tissue imaging: seeing the immune system in a fresh light

2002 • 482 citations

Antigen Presentation in Extracellular Matrix

2000 • 409 citations

Antigen decoding by T lymphocytes: from synapses to fate determination

2001 • 261 citations

The specific direct interaction of helper T cells and antigen-presenting B cells.

1986 • 246 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose.

1989 • 166 citations

Interaction of T cells with APCs: the serial encounter model

2001 • 129 citations

Cytotoxic T Lymphocyte Sequential Killing of Immobilized Allogeneic Tumor Target Cells Measured by Time-Lapse Microcinematography

1978 • 96 citations

A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding

2002 • 89 citations

The β1 and β3 Integrins Promote T Cell Receptor-mediated Cytotoxic T Lymphocyte Activation

2003 • 67 citations

Environmental control of immunological synapse formation and duration

2001 • 59 citations

Cutting Edge: TCR Engagement and Triggering in the Absence of Large-Scale Molecular Segregation at the T Cell-APC Contact Site

2002 • 55 citations

Activation of the extracellular signal-regulated kinase pathway is differentially required for TCR-stimulated production of six cytokines in primary T lymphocytes.

1998 • 52 citations

Kinetics and extent of protein tyrosine kinase activation in individual T cells upon antigenic stimulation

1999 • 32 citations